Impact of exercise training on endothelial transcriptional profiles in healthy swine: A genome-wide microarray analysis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 2, 2011, Pages

  Padilla, Jaume ^a   Simmons, Grant H ^a   Wade Davis, J ^a   Whyte, Jeffrey J ^a   Zderic, Theodore W ^b   Hamilton, Marc T ^b   Bowles, Douglas K ^a,c   Harold Laughlin, M ^a,c,d  

^a UNIVERSITY OF MISSOURI   (United States)

^b PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^c UNIVERSITY OF MISSOURI   (United States)

^d University of Missouri   (United States)

Author keywords

Brachial artery; Chronic exercise; Endothelial phenotype; Internal mammary artery

Indexed keywords

CD53 ANTIGEN; CD79B ANTIGEN; CRYPTOCHROME 1; CYTOCHROME P450 3A4; FOLLISTATIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 2; PENTRAXIN 3; PLECKSTRIN; PROLACTIN RECEPTOR; SECRETOGRANIN II; TRANSCRIPTION FACTOR ARNTL; VERSICAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRACHIAL ARTERY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; EXERCISE; EXPERIMENTAL PIG; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; INTERNAL MAMMARY ARTERY; MALE; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SEDENTARY LIFESTYLE; TREADMILL EXERCISE; UPREGULATION;

ANIMALS; BAYES THEOREM; BRACHIAL ARTERY; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; LINEAR MODELS; MALE; MAMMARY ARTERIES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYSICAL EXERTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SWINE; SWINE, MINIATURE; TIME FACTORS;

EID: 79961044231     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00065.2011     Document Type: Article

References (53)

1. Aird WC. Endothelial cell heterogeneity and atherosclerosis. Curr Atheroscler Rep 8: 69-75, 2006.
2. Aird WC. Spatial and temporal dynamics of the endothelium. J Thromb Haemost 3: 1392-1406, 2005.
3. Alexa A, Rahnenfuhrer J, Lengauer T. Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics 22: 1600-1607, 2006.
4. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet 25: 25-29, 2000.
5. Barone R (Editor). Anatomie Comparee des Mammiferes Domestiques. Paris: Vigot 1996.
6. Beck EB, Erbs S, Mobius-Winkle S, Adams V, Woitek FJ, Walther T, Hambrecht R, Mohr FW, Stumvoll M, Bluher M, Schuler G, Linke A. Exercise training restores the endothelial response to vascular growth factors in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil 2011 Mar 22. [Epub ahead of print].
7. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc Ser B 57: 289-300, 1995.
8. Bey L, Akunuri N, Zhao P, Hoffman EP, Hamilton DG, Hamilton MT. Patterns of global gene expression in rat skeletal muscle during unloading and low-intensity ambulatory activity. Physiol Genomics 13: 157-167, 2003.
9. Calvano SE, Xiao W, Richards DR, Felciano RM, Baker HV, Cho RJ, Chen RO, Brownstein BH, Cobb JP, Tschoeke SK, Miller-Graziano C, Moldawer LL, Mindrinos MN, Davis RW, Tompkins RG, Lowry SF. A network-based analysis of systemic inflammation in humans. Nature 437: 1032-1037, 2005.
10. Carlson M, Falcon S, Pages H, Li N. GO.db: A Set Of Annotation Maps Describing The Entire Gene Ontology. 2.2.2. Rpv.
11. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, Sullivan ID, Lloyd JK, Deanfield JE. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340: 1111-1115, 1992.
12. Civelek M, Manduchi E, Riley RJ, Stoeckert CJ Jr, Davies PF. Chronic endoplasmic reticulum stress activates unfolded protein reponse in arterial endothelium in regions of suceptibility to atherosclerosis. Circ Res 105: 453-461, 2009.
13. Conway DE, Williams MR, Eskin SG, McIntire LV. Endothelial cell responses to atheroprone flow are driven by two separate flow components, low time-average shear stress and fluid flow reversal. Am J Physiol Heart Circ Physiol 298: H367-H374, 2010.
14. Couture O, Callenberg K, Koul N, Pandit S, Younes R, Hu Z, Dekkers J, Reecy J, Honavar V, Tuggle C. ANEXdb: an integrated animal ANnotation and microarray EXpression database. Mamm Genome 20: 768-777, 2009.
15. Critser JK, Laughlin MH, Prather RS, Riley LK. Proceedings of the Conference on Swine in Biomedical Research. ILAR J 50: 89-94, 2009.
16. Dinenno FA, Tanaka H, Monahan KD, Clevenger CM, Eskurza I, DeSouza CA, Seals DR. Regular endurance exercise induces expansive arterial remodelling in the trained limbs of healthy men. J Physiol 534: 287-295, 2001.
17. Falcon S, Gentleman R. Using GOstats to test gene lists for GO term association. Bioinformatics 23: 257-258, 2007.
18. Garcia-Cardena G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90. Nature 392: 821-824, 1998.
19. Gautier L, Cope L, Bolstad BM, Irizarry RA. affy-analysis of Affymetrix GeneGhip data at the probe level. Bioinformatics 20: 307-315, 2004.
20. Geeraert B, De Keyzer D, Davey PC, Crombe F, Benhabiles N, Holvoet P. Oxidized low-density lipoprotein-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs. J Thromb Haemost 5: 2529-2536, 2007.
21. Gentleman R, Huber W, Carey VJ, Irizarry RA, Dudoit S. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer, 2005.
22. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 5: R80, 2004.
23. Grado-Ahuir JA, Aad PY, Ranzenigo G, Caloni F, Cremonesi F, Spicer LJ. Microarray analysis of insulin-like growth factor-I-induced changes in messenger ribonucleic acid expression in cultured porcine granulosa cells: possible role of insulin-like growth factor-I in angiogenesis. J Anim Sci 87: 1921-1933, 2009.
24. Green DJ, Swart A, Exterkate A, Naylor LH, Black MA, Cable NT, Thijssen DHJ. Impact of age, sex and exercise on brachial and popliteal artery remodelling in humans. Atherosclerosis 210: 525-530, 2010.
25. Hambrecht R, Adams V, Erbs S, Linke A, Krankel N, Shu Y, Baither Y, Gielen S, Thiele H, Gummert JF, Mohr FW, Schuler G. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 107: 3152-3158, 2003.
26. Kuster DWD, Merkus D, van der Velden J, Verhoeven AJM, Duncker DJ. "Integrative Physiology 2.0": integration of systems biology into physiology and its application to cardiovascular homeostasis. J Physiol 589: 1037-1045, 2011.
27. LaMack JA, Himburg HA, Friedman MH. Distinct profiles of endothelial gene expression in hyperpermeable regions of the porcine aortic arch and thoracic aorta. Atherosclerosis 195: e35-e41, 2007.
28. Lauer T, Hei BC, Preik M, Balzer J, Hafner D, Strauer BD, Kelm M. Reduction of peripheral flow reserve impairs endothelial function in conduit arteries of patients with essential hypertension. J Hypertens 23: 563-569, 2005.
29. Laughlin MH. Endothelium-mediated control of coronary vascular tone after chronic exercise training. Med Sci Sports Exerc 27: 1135-1144, 1995.
30. Laughlin MH, Joseph B. Wolfe Memorial Lecture. Physical activity in prevention and treatment of coronary disease: the battle line is in exercise vascular cell biology. Med Sci Sports Exer 36: 352-362, 2004.
31. Laughlin MH, Klabunde RE, Delp MD, Armstrong RB. Effects of dipyridamole on muscle blood flow in exercising miniature swine. Am J Physiol Heart Circ Physiol 257: H1507-H1515, 1989.
32. Laughlin MH, Pollock JS, Amann JF, Hollis ML, Woodman CR, Price EM. Training induces nonuniform increases in eNOS content along the coronary arterial tree. J Appl Physiol 90: 501-510, 2001.
33. Laughlin MH, Woodman CR, Schrage WG, Gute D, Price EM. Interval sprint training enhances endothelial function and eNOS content in some arteries that perfuse white gastrocnemius muscle. J Appl Physiol 96: 233-244, 2004.
34. Maeda S, Iemitsu M, Miyauchi T, Kuno S, Matsuda M, Tanaka H. Aortic stiffness and aerobic exercise: mechanistic insight from microarray analyses. Med Sci Sports Exerc 37: 1710-1716, 2005.
35. Maglott D, Ostell J, Pruitt KD, Tatusova T. Entrez gene: gene-centered information at NCBI. Nucleic Acids Res 35: D26-D31, 2007.
36. Maiorana A, O'Driscoll G, Taylor R, Green D. Exercise and the nitric oxide vasodilator system. Sports Med 33: 1013-1035, 2003.
37. McAllister RM, Jasperse JL, Laughlin MH. Nonuniform effects of endurance exercise training on vasodilation in rat skeletal muscle. J Appl Physiol 98: 753-761, 2005.
38. Miguel JC, Chen J, Van Alstine WG, Johnson RW. Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with porcinereproductive and respiratory syndrome virus. Vet Immunol Immunopathol 135: 314-319, 2010.
39. Moyna NM, Thompson PD. The effect of physical activity on endothelial function in man. Acta Physiol Scand 180: 113-123, 2004.
40. Muller JM, Meyers PR, Laughlin MH. Vasodilator responses of coronary resistance arteries of exercise-trained pigs. Circulation 89: 2308-2314, 1994.
41. Padilla J, Newcomer SC, Simmons GH, Kreutzer KV, Laughlin MH. Long-term exercise training does not alter brachial and femoral artery vasomotor function and endothelial phenotype in healthy pigs. Am J Physiol Heart Circ Physiol 299: H379-H385, 2010.
42. Passerini AG, Polacek DC, Shi C, Francesco NM, Manduchi E, Grant GR, Pritchard WF, Powell S, Chang GY, Stoeckert CJ Jr, Davies PF. Coexisting proinflammatory and antioxidative endothleial transcription profiles in a disturbed flow region of the adult porcine aorta. Proc Natl Acad Sci USA 101: 2482-2487, 2004.
43. Roseguini BT, Soylu M, Whyte JJ, Yang HT, Newcomer SC, Laughlin MH. Intermittent pneumatic leg compressions acutely upregulate VEGF and MCP-1 expression in skeletal muscle. Am J Physiol Heart Circ Physiol 298: H1991-H2000, 2010.
44. Smyth GK. Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol 3: article 3, 2004.
45. Srere PA. Citrate synthase. Methods Enzymol 13: 3-5, 1969.
46. Thijssen DHJ, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME, Green DJ. Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300: H2-H12, 2011.
47. Thijssen DHJ, Maiorana AJ, O'Driscoll G, Cable NT, Hopman MTE, Green DJ. Impact of inactivity and exercise on the vasculature in humans. Eur J Appl Physiol 108: 845-875, 2010.
48. Thompson MA, Henderson KK, Woodman CR, Turk JR, Rush JWE, Price EM, Laughlin MH. Exercise preserves endothelium-dependent relaxation in coronary arteries of hypercholesterolemic male pigs. J Appl Physiol 96: 1114-1126, 2004.
49. Tinken TM, Thijssen DHJ, Black MA, Cable NT, Green DJ. Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 586: 5003-5012, 2008.
50. Tinken TM, Thijssen DHJ, Hopkins N, Dawson EA, Cable NT, Green DJ. Shear stress mediates endothelial adaptations to exercise training in humans. Hypertension 55: 312-318, 2010.
51. Trott JF, Horigan KC, Gloviczki JM, Costa KM, Freking BA, Farmer C, Hayashi K, Spencer T, Morabito JE, Hovey RC. Tissue-specific regulation of porcine prolactin receptor expression by estrogen, progesterone, and prolactin. J Endocrinol 202: 153-166, 2009.
52. Whyte JJ, Samuel M, Mahan E, Padilla J, Simmons GH, Arce- Esquivel AA, Bender SB, Whitworth KM, Hao YH, Murphy CN, Walters EM, Prather RS, Laughlin MH. Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res 2010 Dec 18. [Epub ahead of print].
53. Zhu XY, Rodriguez-Porcel M, Bentley MD, Chade AR, Sica V, Napoli C, Cplice N, Ritman EL, Lerman A, Lerman LO. Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia. Circulation 109: 2109-2115, 2004