Glucocorticoid activity during lung maturation is essential in mesenchymal and less in alveolar epithelial cells

Molecular Endocrinology

Volumn 25, Issue 8, 2011, Pages 1280-1288

  Habermehl, Daniel ^a   Parkitna, Jan Rodriguez ^a   Kaden, Sylvia ^b   Brügger, Britta ^c   Wieland, Felix ^c   Gröne, Hermann Josef ^b   Schütz, Günther ^a  

^a Division Molecular Biology of the Cell I   (Germany)

^b Division Cellular and Molecular Pathology   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FETUS LUNG MATURATION; FIBROBLAST; KNOCKOUT MOUSE; LUNG ALVEOLUS CELL; MESENCHYME CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL PROLIFERATION; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOCORTICOIDS; LUNG; MESODERM; MICE; MORPHOGENESIS; ORGAN SPECIFICITY; PHENOTYPE; PNEUMOCYTES; RECEPTORS, GLUCOCORTICOID;

ANIMALIA; MURINAE; MUS;

EID: 79961005597     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0380     Document Type: Article

References (36)

1. Cardoso WV, Lu J 2006 Regulation of early lung morphogenesis: questions, facts and controversies. Development 133:1611-1624
2. Whitsett JA, Matsuzaki Y 2006 Transcriptional regulation of perinatal lung maturation. Pediatr Clin North Am 53:873-887, 8
3. Gilstrap LC, Christensen R, Clewell WH, Dalton ME, Davidson EC, Escobedo MB, Gjerdingen DK, Goddardfinegold J, Golden-berg RK, Grimes DA, Hansen TN, Kauffman RE, Keeler EB, Oh W, Susman EJ, Vogel MG, Avery ME, Ballard PL, Ballard RA, Crowley P, Garite T, Goldenberg RL, Hankins GDV, Jobe AH, Koppe JG, et al. 1995 Effect of corticosteroids for fetal maturation on perinatal outcomes. JAMA 273:413-418
4. Seckl JR 2004 Prenatal glucocorticoids and long-term programming. Eur J Endocrinol 151(Suppl 3):U49-U62
5. Reinisch JM, Simon NG, Karow WG, Gandelman R 1978 Prenatal exposure to prednisone in humans and animals retards intrauterine growth. Science 202:436-438
6. Beato M, Herrlich P, Schutz G 1995 Steroid hormone receptors: many actors in search of a plot. Cell 83:851-857
7. Cole TJ, Blendy JA, Monaghan AP, Krieglstein K, Schmid W, Aguzzi A, Fantuzzi G, Hummler E, Unsicker K, Schutz G 1995 Targeted disruption of the glucocorticoid receptor gene blocks ad-renergic chromaffin cell development and severely retards lung maturation. Genes Dev 9:1608-1621
8. Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schutz G 1998 DNA binding of the glucocorticoid receptor is not essential for survival. Cell 93:531-541
9. Shannon JM, Hyatt BA 2004 Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 66:625-645
10. Tronche F, Kellendonk C, Reichardt HM, Schutz G 1998 Genetic dissection of glucocorticoid receptor function in mice. Curr Opin Genet Dev 8:532-538
11. Okubo T, Hogan BL 2004 Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. J Biol 3:11
12. Tronche F, Kellendonk C, Kretz O, Gass P, Anlag K, Orban PC, Bock R, Klein R, Schutz G 1999 Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet 23:99-103
13. Florin L, Alter H, Grone HJ, Szabowski A, Schutz G, Angel P 2004 Cre recombinase-mediated gene targeting of mesenchymal cells. Genesis 38:139-144
14. Stenmark KR, Gebb SA 2003 Lung vascular development: breathing new life into an old problem. Am J Respir Cell Mol Biol 28: 133-137
15. Constien R, Forde A, Liliensiek B, Grone HJ, Nawroth P, Ham-Merling G, Arnold B 2001 Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30:36-44
16. Kim N, Vu TH 2006 Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development. Birth Defects Res C Embryo Today 78:80-89
17. Mc-Gowan SE, Torday JS 1997 The pulmonary lipofibroblast (lipid interstitial cell) and its contributions to alveolar development. Annu Rev Physiol 59:43-62
18. Besson A, Dowdy SF, Roberts JM 2008 CDK Inhibitors: cell cycle regulators and beyond. Dev Cell 14:159-169
19. Yang JQ, Rudiger JJ, Hughes JM, Goulet S, Gencay-Cornelson MM, Borger P, Tamm M, Roth M 2008 Cell density and serum exposure modify the function of the glucocorticoid receptor C/EBP complex. Am J Respir Cell Mol Biol 38:414-422
20. Maki JM, Sormunen R, Lippo S, Kaarteenaho-Wiik R, Soininen R, Myllyharju J 2005 Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues. Am J Pathol 167:927-936
21. Wendel DP, Taylor DG, Albertine KH, Keating MT, Li DY 2000 Impaired distal airway development in mice lacking elastin. Am J Respir Cell Mol Biol 23:320-326
22. Warburton D, Bellusci S, de Langhe S, del Moral PM, Fleury V, Mailleux A, Tefft D, Unbekandt M, Wang K, Shi W 2005 Molecular mechanisms of early lung specification and branching morphogenesis. Pediatr Res 57:26R-37R
23. Mendelson CR 2000 Role of transcription factors in fetal lung development and surfactant protein gene expression. Annu Rev Physiol 62:875-915
24. Itani OA, Auerbach SD, Husted RF, Volk KA, Ageloff S, Knepper MA, Stokes JB, Thomas CP 2002 Glucocorticoid-stimulated lung epithelial Na(+) transport is associated with regulated ENaC and sgk1 expression. Am J Physiol Lung Cell Mol Physiol 282:L631-L641
25. Nakamura K, Stokes JB, Mc-Cray PB 2002 Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung. Am J Physiol Cell Physiol 283:C762-C772
26. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC 1996 Early death due to defective neonatal lung liquid clearance in a-ENaC-deficient mice. Nat Genet 12:325-328
27. Manwani N, Gagnon S, Post M, Joza S, Muglia L, Cornejo S, Kaplan F, Sweezey NB 2010 Reduced viability of mice with lung epithelial-specific knockout of glucocorticoid receptor. Am J Respir Cell Mol Biol 43:599-606
28. Morimoto M, Kopan R 2009 rtTA toxicity limits the usefulness of the SP-C-rtTA transgenic mouse. Dev Biol 325:171-178
29. Whitsett JA, Perl AK 2006 Conditional control of gene expression in the respiratory epithelium: a cautionary note. Am J Respir Cell Mol Biol 34:519-520
30. Smith BT 1979 Lung maturation in the fetal rat: acceleration by injection of fibroblast-pneumonocyte factor. Science 204:1094-1095
31. Chelly N, Henrion A, Pinteur C, Chailley-Heu B, Bourbon JR 2001 Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme. Endocrinology 142:1814-1819
32. Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D, Hynes RO 2002 Central roles of a5β1 integrin and fibronec-tin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol 22:927-933
33. Nguyen NM, Senior RM 2006 Laminin isoforms and lung development: all isoforms are not equal. Dev Biol 294:271-279
34. Sakai T, Larsen M, Yamada KM 2003 Fibronectin requirement in branching morphogenesis. Nature 423:876-881
35. ten Dijke P, Arthur HM 2007 Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 8:857-869
36. Brugger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms JB, Lehmann WD, Nickel W, Wieland FT 2000 Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol 151:507-518