An undecided coiled coil: The leucine zipper of Nek2 kinase exhibits atypical conformational exchange dynamics

Journal of Biological Chemistry

Volumn 286, Issue 31, 2011, Pages 27537-27547

  Croasdale, Rebecca ^a   Ivins, Frank J ^b   Muskett, Fred ^a   Daviter, Tina ^c   Scott, David J ^d   Hardy, Tara ^a   Smerdon, Steven J ^b   Fry, Andrew M ^a   Pfuhl, Mark ^e  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COILED COIL; CONFORMATIONAL EXCHANGE; CROSS PEAKS; EXTERNAL SIGNALS; FRAMESHIFT; HYDROPHOBIC POSITIONS; INTERCONVERSIONS; LEUCINE ZIPPERS; MICROTUBULE-BINDING DOMAINS;

ENZYMES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; OLIGOMERS; TRANSCRIPTION FACTORS;

AMINO ACIDS;

CYSTEINE; DYNEIN ADENOSINE TRIPHOSPHATASE; LEUCINE; NEK2 KINASE; NITROGEN 15; PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE MUTATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; MICROTUBULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OLIGOMERIZATION; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

BASE SEQUENCE; CIRCULAR DICHROISM; DNA PRIMERS; HUMANS; LEUCINE ZIPPERS; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN-SERINE-THREONINE KINASES; ULTRACENTRIFUGATION;

EID: 79961000136     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196972     Document Type: Article

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