Antigen-specific T cell responses to BK polyomavirus antigens identify functional anti-viral immunity and may help to guide immunosuppression following renal transplantation

Clinical and Experimental Immunology

Volumn 165, Issue 3, 2011, Pages 401-409

  Chakera, A ^a,b   Bennett, S ^a   Lawrence, S ^a   Morteau, O ^a   Mason, P D ^b   O'Callaghan, C A ^a,b   Cornall, R J ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

ELISPOT; Polyomavirus BK; Renal transplantation

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN 1; IMMEDIATE EARLY PROTEIN BZLF1; PHYTOHEMAGGLUTININ; VIRUS ANTIGEN;

ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATIONAL STUDY; EPSTEIN BARR VIRUS; GRAFT RECIPIENT; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; KIDNEY TRANSPLANTATION; POLYOMA VIRUS; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REACTIVATION; VIRUS REPLICATION;

ADULT; AGED; ANTIGENS, VIRAL; ANTIGENS, VIRAL, TUMOR; BK VIRUS; CAPSID PROTEINS; ENZYME-LINKED IMMUNOSPOT ASSAY; HUMANS; IMMUNOSUPPRESSION; IMMUNOSUPPRESSIVE AGENTS; INTERFERON-GAMMA; KIDNEY TRANSPLANTATION; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MIDDLE AGED; POLYOMAVIRUS INFECTIONS; T-LYMPHOCYTES; TUMOR VIRUS INFECTIONS; VIREMIA; VIRUS REPLICATION;

EID: 79960989809     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2011.04429.x     Document Type: Article

References (53)

1. Gardner SD, Field AM, Coleman DV, Hulme B. New human papovavirus (B.K.) isolated from urine after renal transplantation. Lancet 1971; 1:1253-7.
2. Boothpur R, Brennan DC. Human polyoma viruses and disease with emphasis on clinical BK and JC. J Clin Virol 2010; 47:306-12.
3. Chesters PM, Heritage J, McCance DJ. Persistence of DNA sequences of BK virus and JC virus in normal human tissues and in diseased tissues. J Infect Dis 1983; 147:676-84.
4. Heritage J, Chesters PM, McCance DJ. The persistence of papovavirus BK DNA sequences in normal human renal tissue. J Med Virol 1981; 8:143-50.
5. Hirsch HH, Brennan DC, Drachenberg CB etal. Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations. Transplantation 2005; 79:1277-86.
6. Thamboo TP, Jeffery KJM, Friend PJ, Turner GDH, Roberts ISD. Urine cytology screening for polyoma virus infection following renal transplantation: the Oxford experience. J Clin Pathol 2007; 60:927-30.
7. Babel N, Fendt J, Karaivanov S etal. Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: analysis of 4128 urine and serum samples. Transplantation 2009; 88:89-95.
8. Hirsch HH, Knowles W, Dickenmann M etal. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Engl J Med 2002; 347:488-96.
9. Dharnidharka VR, Cherikh WS, Abbott KC. An OPTN analysis of national registry data on treatment of BK virus allograft nephropathy in the United States. Transplantation 2009; 87:1019-26.
10. Johnston O, Jaswal D, Gill JS, Doucette S, Fergusson DA, Knoll GA. Treatment of polyomavirus infection in kidney transplant recipients: a systematic review. Transplantation 2010; 89:1057-70.
11. Prosser SE, Orentas RJ, Jurgens L, Cohen EP, Hariharan S. Recovery of BK virus large T-antigen-specific cellular immune response correlates with resolution of BK virus nephritis. Transplantation 2008; 85:185-92.
12. Binggeli S, Egli A, Schaub S etal. Polyomavirus BK-specific cellular immune response to VP1 and large T-antigen in kidney transplant recipients. Am J Transplant 2007; 7:1131-9.
13. Li J, Melenhorst J, Hensel N etal. T-cell responses to peptide fragments of the BK virus T antigen: implications for cross-reactivity of immune response to JC virus. J Gen Virol 2006; 87:2951-60.
14. Muller K, Schachtner T, Sattler A etal. BK-VP3 as a new target of cellular immunity in BK virus infection. Transplantation 2010; 91:100-7.
15. Schmittel A, Keilholz U, Scheibenbogen C. Evaluation of the interferon-gamma ELISPOT-assay for quantification of peptide specific T lymphocytes from peripheral blood. J Immunol Methods 1997; 210:167-74.
16. Lalvani A. Counting antigen-specific T cells: a new approach for monitoring response to tuberculosis treatment? Clin Infect Dis 2004; 38:757-9.
17. Rohrbach J, Robinson N, Harcourt G etal. Cellular immune responses to HCV core increase and HCV RNA levels decrease during successful antiretroviral therapy. Gut 2010; 59:1252-8.
18. Lauer GM, Lucas M, Timm J etal. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol 2005; 79:12979-88.
19. Streeck H, Frahm N, Walker BD. The role of IFN-gamma Elispot assay in HIV vaccine research. Nat Protoc 2009; 4:461-9.
20. Wiseman AC. Polyomavirus nephropathy: a current perspective and clinical considerations. Am J Kidney Dis 2009; 54:131-42.
21. Vasudev B, Hariharan S, Hussain SA, Zhu YR, Bresnahan BA, Cohen EP. BK virus nephritis: risk factors, timing, and outcome in renal transplant recipients. Kidney Int 2005; 68:1834-9.
22. Schaub S, Hirsch HH, Dickenmann M etal. Reducing immunosuppression preserves allograft function in presumptive and definitive polyomavirus-associated nephropathy. Am J Transplant 2010; 10:2615-23.
23. Binet I, Nickeleit V, Hirsch HH etal. Polyomavirus disease under new immunosuppressive drugs: a cause of renal graft dysfunction and graft loss. Transplantation 1999; 67:918-22.
24. Mengel M, Marwedel M, Radermacher J etal. Incidence of polyomavirus-nephropathy in renal allografts: influence of modern immunosuppressive drugs. Nephrol Dial Transplant 2003; 18:1190-6.
25. Egli A, Kohli S, Dickenmann M, Hirsch HH. Inhibition of polyomavirus BK-specific T-cell responses by immunosuppressive drugs. Transplantation 2009; 88:1161-8.
26. Magliocca JF, Odorico JS, Pirsch JD etal. A comparison of alemtuzumab with basiliximab induction in simultaneous pancreas-kidney transplantation. Am J Transplant 2008; 8:1702-10.
27. Kayler LK, Mohanka R, Morgan C, Basu A, Shapiro R, Randhawa PS. Clinical course of kidney transplant patients with acute rejection and BK virus replication following Campath therapy. Clin Transplant 2008; 22:348-53.
28. Comoli P, Hirsch HH, Ginevri F. Cellular immune responses to BK virus. Curr Opin Organ Transplant 2008; 13:569-74.
29. Stolt A, Sasnauskas K, Koskela P, Lehtinen M, Dillner J. Seroepidemiology of the human polyomaviruses. J Gen Virol 2003; 84:1499-504.
30. Kean JM, Rao S, Wang M, Garcea RL. Seroepidemiology of human polyomaviruses. PLoS Pathog 2009; 5:e1000363.
31. Zhong S, Zheng HY, Suzuki M etal. Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals. J Clin Microbiol 2007; 45:193-8.
32. Rajpoot DK, Gomez A, Tsang W, Shanberg A. Ureteric and urethral stenosis: a complication of BK virus infection in a pediatric renal transplant patient. Pediatr Transplant 2007; 11:433-5.
33. Hogan TF, Borden EC, McBain JA, Padgett BL, Walker DL. Human polyomavirus infections with JC virus and BK virus in renal transplant patients. Ann Intern Med 1980; 92:373-8.
34. Arthur RR, Shah KV, Baust SJ, Santos GW, Saral R. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants. N Engl J Med 1986; 315:230-4.
35. Haririan A, Ramos ER, Drachenberg CB, Weir MR, Klassen DK. Polyomavirus nephropathy in native kidneys of a solitary pancreas transplant recipient. Transplantation 2002; 73:1350-3.
36. Etienne I, Francois A, Redonnet M etal. Does polyomavirus infection induce renal failure in cardiac transplant recipients? Transplant Proc 2000; 32:2794-5.
37. Puliyanda DP, Amet N, Dhawan A etal. Isolated heart and liver transplant recipients are at low risk for polyomavirus BKV nephropathy. Clin Transplant 2006; 20:289-94.
38. Thomas LD, Milstone AP, Vilchez RA, Zanwar P, Butel JS, Dummer JS. Polyomavirus infection and its impact on renal function and long-term outcomes after lung transplantation. Transplantation 2009; 88:360-6.
39. Atencio IA, Shadan FF, Zhou XJ, Vaziri ND, Villarreal LP. Adult mouse kidneys become permissive to acute polyomavirus infection and reactivate persistent infections in response to cellular damage and regeneration. J Virol 1993; 67:1424-32.
40. Fishman JA. BK virus nephropathy - polyomavirus adding insult to injury. N Engl J Med 2002; 347:527-30.
41. Bennett WM, Meyer L, Ridenour J, Batiuk TD. Surveillance and modification of immunosuppression minimizes BK virus nephropathy. Am J Nephrol 2010; 32:10-12.
42. Lukacher AE, Moser JM, Hadley A, Altman JD. Visualization of polyoma virus-specific CD8+ T cells in vivo during infection and tumor rejection. J Immunol 1999; 163:3369-78.
43. Comoli P, Binggeli S, Ginevri F, Hirsch HH. Polyomavirus-associated nephropathy: update on BK virus-specific immunity. Transpl Infect Dis 2006; 8:86-94.
44. Cox JH, Ferrari G, Kalams SA, Lopaczynski W, Oden N, D'Souza MP. Results of an ELISPOT proficiency panel conducted in 11 laboratories participating in international human immunodeficiency virus type 1 vaccine trials. AIDS Res Hum Retroviruses 2005; 21:68-81.
45. Bonilla N, Barget N, Andrieu M etal. Interferon gamma-secreting HCV-specific CD8+ T cells in the liver of patients with chronic C hepatitis: relation to liver fibrosis - ANRS HC EP07 study. J Viral Hepat 2006; 13:474-81.
46. Cattamanchi A, Ssewenyana I, Davis JL etal. Role of interferon-gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection. BMC Infect Dis 2010; 10:75.
47. Cattamanchi A, Smith R, Steingart KR etal. Interferon-gamma release assays for the diagnosis of latent tuberculosis infection in HIV-infected individuals: a systematic review and meta-analysis. J Acquir Immune Defic Syndr 2011; 56:230-8.
48. McCall MB, Sauerwein RW. Interferon-gamma - central mediator of protective immune responses against the pre-erythrocytic and blood stage of malaria. J Leukoc Biol 2010; 88:1131-43.
49. Leuenberger D, Andresen PA, Gosert R etal. Human polyomavirus type 1 (BK virus) agnoprotein is abundantly expressed but immunologically ignored. Clin Vaccine Immunol 2007; 14:959-68.
50. Randhawa PS, Popescu I, Macedo C etal. Detection of CD8+ T cells sensitized to BK virus large T antigen in healthy volunteers and kidney transplant recipients. Hum Immunol 2006; 67:298-302.
51. Nair V, Zavolan M. Virus-encoded microRNAs: novel regulators of gene expression. Trends Microbiol 2006; 14:169-75.
52. Sullivan CS, Grundhoff AT, Tevethia S, Pipas JM, Ganem D. SV40-encoded microRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature 2005; 435:682-6.
53. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3:611-23.