Sustained BK viruria as an early marker for the development of BKV-associated nephropathy: Analysis of 4128 urine and serum samples

Transplantation

Volumn 88, Issue 1, 2009, Pages 89-95

  Babel, Nina ^a   Fendt, Juliane ^a   Karaivanov, Stoyan ^a   Bold, Gantuja ^a   Arnold, Steffen ^a   Sefrin, Anett ^a   Lieske, Evelyn ^a   Hoffzimmer, Martin ^a   Dziubianau, Mikalai ^a   Bethke, Nicole ^a   Meisel, Christian ^a   Grütz, Gerald ^a   Reinke, Petra ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

BKV; PCR; Renal transplantation; Serum; Urine

Indexed keywords

ADULT; ARTICLE; BK VIRUS; BK VIRUS ASSOCIATED NEPHROPATHY; DISEASE MARKER; EARLY DIAGNOSIS; FEMALE; HUMAN; KIDNEY DISEASE; KIDNEY INFECTION; MAJOR CLINICAL STUDY; MALE; PREDICTION; PRIORITY JOURNAL; RELIABILITY; SENSITIVITY AND SPECIFICITY; SERUM; URINALYSIS; UROTHELIUM; VIREMIA; VIRURIA; VIRUS DETECTION; VIRUS EXCRETION; VIRUS LOAD; BLOOD; COMPARATIVE STUDY; CROSS-SECTIONAL STUDY; GENETICS; ISOLATION AND PURIFICATION; KAPLAN MEIER METHOD; KIDNEY TRANSPLANTATION; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTION AND FORECASTING; PREVALENCE; PROSPECTIVE STUDY; REPRODUCIBILITY; RISK ASSESSMENT; STATISTICAL MODEL; TIME; URINE; VIROLOGY; VIRUS ACTIVATION; VIRUS INFECTION;

VIRUS DNA;

ADULT; BK VIRUS; CROSS-SECTIONAL STUDIES; DNA, VIRAL; EARLY DIAGNOSIS; FEMALE; HUMANS; KAPLAN-MEIERS ESTIMATE; KIDNEY DISEASES; KIDNEY TRANSPLANTATION; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYOMAVIRUS INFECTIONS; PREDICTIVE VALUE OF TESTS; PREVALENCE; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; TIME FACTORS; VIRAL LOAD; VIREMIA; VIRUS ACTIVATION;

EID: 67651021382     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181aa8f62     Document Type: Article

References (18)

1. Bonvoisin C, Weekers L, Xhignesse P, et al. Polyomavirus in renal transplantation: A hot problem. Transplantation 2008; 85(7 suppl): S42.
2. Knowles WA, Pipkin P, Andrews N, et al. Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40. J Med Virol 2003; 71: 115.
3. Polo C, Perez JL, Mielnichuck A, et al. Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children. Clin Microbiol Infect 2004; 10: 640.
4. Hirsch HH, Steiger J. Polyomavirus BK. Lancet Infect Dis 2003; 3: 611.
5. Vasudev B, Hariharan S, Hussain SA, et al. BK virus nephritis: Risk factors, timing, and outcome in renal transplant recipients. Kidney Int 2005; 68: 1834.
6. Ramos E, Drachenberg CB, Portocarrero M, et al. BK virus nephropathy diagnosis and treatment: Experience at the University of Maryland Renal Transplant Program. Clin Transplants 2002; 143.
7. Wadei HM, Rule AD, Lewin M, et al. Kidney transplant function and histological clearance of virus following diagnosis of polyomavirus-associated nephropathy (PVAN). Am J Transplant 2006; 6: 1025.
8. Brennan DC, Agha I, Bohl DL, et al. Incidence of BK with tacrolimus versus cyclosporine and impact of preemptive immunosuppression reduction. Am J Transplant 2005; 5: 582.
9. Hirsch HH. Polyomavirus associated nephropathy. A new opportunistic complication after kidney transplantation. Der Internist 2003; 44: 653.
10. Alméras C, Foulongne V, Garrigue V, et al. Does reduction in immunosuppression in viremic patients prevent BK virus nephropathy in de novo renal transplant recipients? A prospective study. Transplantation 2008; 85: 1099.
11. Hirsch HH, Brennan DC, Drachenberg CB, et al. Polyoma--virus associated nephropathy in renal transplantation: Interdisciplinary analyses and recommendations. Transplantation 2005; 79: 1277.
12. Schubert S, Renner C, Hammer M, et al. Relationship of immunosuppression to Epstein-Barr viral load and lymphoproliferative disease in pediatric heart transplant patients. J Heart Lung Transplant 2008; 27: 100.
13. Drachenberg CB, Papadimitriou JC, Wali R, et al. BK polyoma virus allograft nephropathy: Ultrastructural features from viral cell entry to lysis. Am J Transplant 2003; 3: 1383.
14. Hirsch HH, Knowles W, Dickenmann M, et al. Prospective study of polyomavirus type BK replication and nephropathy in renal-transplant recipients. N Eng J Med 2002; 347:488.
15. Dadhania D, Snopkowski C, Ding R, et al. Epidemiology of BK virus in renal allograft recipients: Independent risk factors for BK virus replication. Transplantation 2008; 5: 582.
16. Viscount HB, Eid AJ, Espy MJ, et al. Polyomavirus polymerase chain reaction as a surrogate marker of polyomavirus-associated nephropathy. Transplantation 2007; 84: 340.
17. Bressollette-Bodin C, Coste-Burel M, Hourmant M, et al. Aprospective longitudinal study of BK virus infection in 104 renal transplant recipients. Am J Transplant 2005; 5: 1926.
18. Awadalla Y, Randhawa P, Ruppert K, et al. HLA mismatching increases the risk of BK virus nephropathy in renal transplant recipients. Am J Transplant 2004; 4: 1691.