Oral magnesium treatment in patients with neuropathic pain: A randomized clinical trial

Magnesium Research

Volumn 24, Issue 2, 2011, Pages 28-35

  Pickering, Gisèle ^a,b,c   Morel, Véronique ^a,b   Simen, Estelle ^a   Cardot, Jean Michel ^b   Moustafa, Fares ^a   Delage, Noémie ^d   Picard, Pascale ^d   Eschalier, Sylvie ^a   Boulliau, Sylvia ^a   Dubray, Claude ^a,b,c  

^a UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^b INSERM   (France)

^c UNIVERSITÉ CLERMONT AUVERGNE   (France)

^d CHUClermont Ferrand   (France)

Author keywords

Emotion; Neuropathy; Pain paroxysm; Placebo; Quality of life

Indexed keywords

MAGNESIUM;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; MALE; MIDDLE AGED; NEURALGIA; ORAL DRUG ADMINISTRATION; PROSPECTIVE STUDY; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; ADULT; AGED; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MAGNESIUM; MALE; MIDDLE AGED; NEURALGIA; PROSPECTIVE STUDIES; QUALITY OF LIFE; QUESTIONNAIRES;

ANIMALIA;

EID: 79960988681     PISSN: 09531424     EISSN: 19524021     Source Type: Journal    
DOI: 10.1684/mrh.2011.0282     Document Type: Article

References (48)

1. Begon S, Pickering G, Eschalier A, Dubray C. Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain. Brain Research 2000; 887: 436-9.
2. Begon S, Pickering G, Eschalier A, Mazur A, Rayssiguier Y, Dubray C. Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats. Br J of Pharmacology 2001; 134: 1227-36.
3. Begon S, Pickering G, Eschalier A, Dubray C. Magnesium increases Morphine analgesic effect in different experimental models of pain. Anesthesiology 2002; 96: 627-32.
4. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-Methyl-D-aspartic acid receptor activation; implication for the treatment of post-injury pain hypersensitivity states. Pain 1991; 44: 293-9.
5. Dingledine R, Borges K, Bowie D and Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev 1999; 51: 7-61.
6. Niewoehner B, Single FN, Hvalby Ø, Jensen V, Meyerzum Alten Borgloh S, Seeburg PH, Rawlins JN, Sprengel R, Bannerman DM. Impaired spatial working memory but spared spatial reference memory following functional loss ofNMDAreceptors in the dentate gyrus. Eur J Neurosci 2007; 25: 837-46.
7. Nowack L, Bregestovski L, Ascher P, Herbet A, Prochiants A. Magnesium gates glutamate-activated channels in mouse central neurons. Nature 1984; 307: 462-5.
8. Malcangio M, Tomlinson A. A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/ diabetic rats. Pain 1998; 76: 151-7.
9. Wei H, Pertovaara A. Influence of preemptive treatment with MK-801, an N-methyl-D-aspartate receptor antagonist, on development of neuropathic symptoms induced by spinal nerve ligation in the rat. Anesthesiology 1999; 91: 313-6.
10. Haley JE, Sullivan AF, Dickenson AH. Evidence for spinal NMDA receptor involvement in prolonged chemical nociception in rat acute pain models. Anaesthesia 1990; 54: 241-6.
11. Backonja M, Arndt G, Gombar KA, Check B, Zimmermann M. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994; 56: 51-7.
12. Olney JW. Excitotoxic amino acids and neuropsychiatrics disorders. Ann Rev Pharm Toxicol 1990; 30: 47-71.
13. Xiao WH, Bennett GJ. Magnesium suppresses neuropathic pain responses in rats via a spinal site of action. Brain Research 1994; 666: 168-72.
14. Ishizaki K, Sasaki M, Karasawa S, Obata H, Nara T, Goto F. The effect of intrathecal administration of magnesium sulphate on nociception in rat acute pain models. Anesthesia 1999; 54: 241-6.
15. Takano Y, Sato E, Kaneko T, Sato I. Antihyperalgesic effects of intrathecally administered magnesium sulphate in rats. Pain 2000; 84: 175-9.
16. Affolter N, Krahenbuhl S, Schlienger R. Appropriateness of serum level determinations of antiepileptic drugs. Swiss Med Wkly 2003; 133: 591-7.
17. Agmon A, Wells JE. The role of the hyperpolarization-activated cationic current I(h) in the timing of interictal bursts in the neonatal hippocampus. J Neuroscience 2003; 23: 3658-68.
18. Dubray C, Alloui A, Bardin L, Rock E, Mazur A, Rayssiguier Y, Eschalier A, Lavarenne J. Magnesium deficiency induced an hyperalgesia reversed by theNMDAreceptor antagonist MK-801. Neuroreport 1997; 8: 1383-6.
19. Rondón LJ, Privat AM, Daulhac L, Davin N, Mazur A, Fialip J, Eschalier A, Courteix C. Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain. J Physiol 2010; 588: 4205-15.
20. Jeong SM, Hahm KD, Shin JW, Leem JG, Lee C, Han SM. Changes in magnesium concentration in the serum and cerebrospinal fluid of neuropathic rats. Acta Anaesththesiol Scand 2006; 50: 211-6.
21. Collins S, Zuurmond WW, de Lange JJ, van Hilten BJ, Perez RS. Intravenous magnesium for complex regional pain syndrome type 1 (CRPS 1) patients: a pilot study. Pain medicine 2009; 10: 930-40.
22. Rondanelli M, Opizzi A, Monteferrario F, Antoniello N, Manni R, Klersy C. The effect of melatonin, magnesium, and zinc on primary insomnia in longterm care facility residents in Italy: a double-blind, placebo-controlled clinical trial. J Am Geriatr Soc 2011; 59: 82-90.
23. Shechter M, Bairey Merz CN, Stuehlinger HG, Slany J, Pachinger O, Rabinowitz B. Effects of oral magnesium therapy on exercise tolerance, exercise-induced chest pain, and quality of life in patients with coronary artery disease. Am J Cardiol 2003; 91: 517-21.
24. Bhatia A, Kashyap L, Pawar DK, Trikha A. Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy. J Clin Anaesth 2004; 16: 262-5.
25. Buvanendran A, McCarthy RJ, Kroin JS, Leong W, Perry P, Tuman KJ. Intrathecal magnesium prolongs fentanyl analgesia: a prospective, randomized, controlled trial. Anaesth Analg 2002; 95: 661-6.
26. Kara H, Sahin N, Ulusan V, Aydogdu T. Magnesium infusion reduces perioperative pain. Eur J Anaesthesiol 2002; 19: 52-6.
27. Ozcan PE, Tugrul S, Senturk NM, Uludag E, Cakar N, Telci L, Esen F. Role of magnesium sulphate in postoperative pain management for patients undergoing thoracotomy. J Cardiothorac Vasc Anaesth 2007; 21: 827-31.
28. Saadawy IM, Kaki AM, Abd EL, Latif AA, Abd-Elmaksoud AM, Tollba OM. Lidocaine vs. magnesium: effect on analgesia after a la paroscopic cholecystectomy. Acta Anaesthesiol Scand 2010; 54: 549-56.
29. Tramèr MR, Glynn CJ. Magnesium Bier's block for treatment of chronic limb pain: a randomised, double-blind, cross-over study. Pain 2002; 99: 235-41.
30. Brill S, Sedgwick PM, Hamann W, Di Vadi PP. Efficacy of intravenous magnesium in neuropathic pain. Br J Anaesth 2002; 89: 711-4.
31. Felsby S, Nielsen J, Arendt-Nielsen L, Jensen TS. NMDA receptor blockade in chronic neuropathic pain: a comparison of ketamine and magnesium chloride. Pain 1996; 64: 283-91.
32. Tanaka M, Shimizu S, Nishimura W, Mine O, Akatsuka M, Inamori K, Mori H. Relief of neuropathic pain with intravenous magnesium. Masui 1998; 47: 1109-13.
33. Huskisson E, Maggini S, Ruf M. The Influence of Micronutrients on Cognitive Function and Performance. J Int Med Res 2007; 35: 1-19.
34. Bouhassira D, Attal N, Fermanian J, Alchaar H, Gautron M, Masquelier E, Rostaing S, Lanteri-Minet M, Collin E, Grisart J, Boureau F. Development and validation of the Neuropathic Pain Symptom Inventory. Pain 2004; 108: 248-57.
35. Zigmond AS, Snaith RP:The hospital anxiety and depression scale. Acta Psychiatr Scand 1983; 67: 361-70.
36. Brazier JE, Harper R, Jones NMB, O'Cathian A, Thomas KJ, Unsherwood T, Westlake L. Validating the SF-36 health survey questionnaire: new outcome measure for primary care. Br Med J 1992; 305: 160-4.
37. Crombez G, Wiech K. You may (not always) experience what you expect: In search for the limits of the placebo and nocebo effect. Pain 2011 [Epub ahead of print].
38. Lui F, Colloca L, Duzzi D, Anchisi D, Benedetti F, Porro CA. Neural bases of conditioned placebo analgesia. Pain 2010; 151: 816-24.
39. Finniss DG, Benedetti F. Mechanisms of the placebo response and their impact on clinical trials and clinical practice. Pain 2005; 114: 3-6.
40. Pickering G, Leplege A. Herpes Zoster Pain, Postherpetic Neuralgia, and Quality of Life in the Elderly. Pain Pract 2010 [Epub ahead of print].
41. Murck H. Magnesium and affective disorders. Nutr Neurosci 2002; 5: 375-89.
42. Corsonello A, Pedone C, Pahor M, Malara A, Carosella L, Mazzei B, Onder G, Corsonello F, Carbonin P, Corica F; Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA). Serum magnesium levels and cognitive impairment in hospitalized hypertensive patients. Magnes Res 2001; 14: 273-82.
43. Hoane MR. Assessment of cognitive function following magnesium therapy in the traumatically injured brain. Magnes Res 2007; 20: 229-36.
44. Martínez G, Ropero C, Funes A, Flores E, Blotta C, Landa AI, Garguilo PA. Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test. Physiol Behav 2002; 76: 219-24.
45. Laarakker MC, van Lith HA, Ohl F. Behavioral characterization of A/J and C57BL/6J mice using a multidimensional test: association between blood plasma and brain magnesium-ion concentration with anxiety. Physiol Behav 2011; 102: 205-19.
46. Peyron R, Laurent B, García-Larrea L. Functional imaging of brain responses to pain. A review and meta-analysis. Neurophysiol Clin 2000; 30: 263-88.
47. LeDoux JE. Emotion circuits in the brain. Ann Rev Neurosci 2000; 23: 155-84.
48. Linder J, Brismar K, Beck-Friis J, Sääf J, Wetterberg L. Calcium and magnesium concentrations in affective disorders: difference between plasma and serum in relation to symptoms. Acta Psychiatr Scand 1989; 80: 527-37.