Serum magnesium levels and cognitive impairment in hospitalized hypertensive patients

Magnesium Research

Volumn 14, Issue 4, 2001, Pages 273-282

  Corsonello, Andrea ^a   Pedone, Claudio ^b   Pahor, Marco ^c   Malara, Alba ^e   Carosella, Luciana ^b   Mazzei, Bruno ^a   Onder, Graziano ^b   Corsonello, Francesco ^a   Carbonin, Pierugo ^b   Corica, Francesco ^d  

^a INRCA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d Salita Villa Contino   (Italy)

^e NONE

Author keywords

Cognitive impairment; Elderly; Hypertension; Serum magnesium

Indexed keywords

MAGNESIUM;

AGED; ARTICLE; BLOOD; CLINICAL TRIAL; COGNITIVE DEFECT; FEMALE; HOSPITALIZATION; HUMAN; HYPERTENSION; MALE; MIDDLE AGED; MULTICENTER STUDY; REGRESSION ANALYSIS;

AGED; COGNITION DISORDERS; FEMALE; HOSPITALIZATION; HUMANS; HYPERTENSION; MAGNESIUM; MALE; MIDDLE AGED; REGRESSION ANALYSIS;

EID: 0035747791     PISSN: 09531424     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Durlach, J., Bac, P., Durlach, V., Durlach, A., Bara, M. & Guiet Bara, A. (1997) Are age-related neurodegenerative diseases linked with various types of magnesium depletion? Magnes. Res. 10, 339-353.
2. Lawler, B.A. & Davis, K.L. (1992) Does modulation of glutamatergic function represent a viable therapeutic strategy in Alzheimer's disease? Biol. Psychiatr. 31, 337-350.
3. 31P NMR and morphological findings in Alzheimer's disease. Arch. Neural. 35, 1556-1561.
4. Gibson, G.E. & Peterson, C. (1987) Calcium and aging nervous system. Neurobiol. Aging. 9, 329-344.
5. Gibson, B.L. & Reif-Lehrer, L. (1985) Magnesium reduces N-melhyl-D-aspartate neurotoxicity in embryonic chick neural retina in vitro. Neurosci. Lett. 57, 13-18.
6. Ebel, H. & Gunther, T. (1980) Magnesium metabolism: a review. J. Clin. Chem. Biochem. 18, 257-270.
7. Halliwell, B. (1989) Oxidants and the central nervous system: some fundamental questions. Is oxidanl damage relevant to Parkinson's disease. Alzheimer's disease, traumatic injury or stroke? Acta. Neurol. Scand. 126. 23-33.
8. Alvarez-Leefmans, F.J., Giraldez, F. & Gamino, S.M. (1987) Intracellular free magnesium in excitable cells: its measurement and its biological significance. Can. J. Physiol. Pharmacol. 65, 915-925.
9. Lemke, L.R. (1994) Blood magnesium levels in advanced dementia. Possible relevance of physiological calcium antagonism. In Magnesium 1993, S. Golf, D. Dralle & L. Vecchiet. London: John Libbey & Co, pp. 199-202.
10. Starr, J.M., Deary, I.J., Inrh, S., Cross. S. & MacLennan, W.J. (1997) Blood pressure and cognitive decline in healthy old people. J. Hum. Hypertens. 11, 777-781.
11. Kilander, L., Nyman, H., Boberg, M., Hansson, L. & Lithell, H. (1998) Hypertension is related to cognitive impairment: a 20-year follow-up of 999 men. Hypertension 31, 780-786.
12. Palombo, V., Scurti, R. Muscari, A., Puddu, G.M., Di Iorio, A., Zito, M. & Abate, G. (1997) Blood pressure and intellectual function in elderly subjects. Age Ageing 26, 91-98.
13. + in platelets and erythrocytes of essential hypertension patients: relation to blood pressure. Clin. Exp. Hypertens. A14, 1189-1209.
14. Resnick, L.M., Gupta, R.K., Bhargava, K.K., Gruenspan, H., Alderman, M.H. & Laragh, J.H. (1991) Cellular ions in hypertension, diabetes, and obesity. A nuclear magnetic resonance spectroscopic study. Hypertension 17, 951-957
15. Paolisso, G. & Barbagallo, M. (1997) Hypertension, diabetes mellitus and insulin resistance. The role of intracellular magnesium. Am. J. Hypertens. 10, 346-355.
16. Carosella, L., Pahor, M., Pedone, C., Zuccala, G., Manto, A. & Carbonin, P. (1999) Pharmacosurveillance in hospitalized patients in Italy. Study design of the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA). Pharmacol. Res. 40, 287-95.
17. Pahor, M., Guralnik, J.M., Gambassi, G. Jr., Bernabei, R., Carosella, L. & Carbonin, P.U. (1993) The impact of age on the risk of adverse drug reactions to digoxin. J. Clin. Epidemiol 46, 1305-1314.
18. Pahor, M., Bernabei, R., Carosella, L., Gambassi, G. Jr., Manto, A. & Carbonin, P.U. (1993) Mental status can bias detection of adverse drug reactions in hospitalized patients. Facts. Res. Gerontol. 7, 271-275.
19. Carbonin, P.D., Pahor, M., Bernabei, R & Sgadari, A. (1991) Is age an independent risk factor of adverse drug reactions in hospitalized medical parients? J. Am. Geriatr. Soc. 39, 1093-1099.
20. Blessed, G., Tomlinson, B.E. & Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br. J. Psychiatry 114, 797-811
21. Hodkinson, H.M. (1972) Evaluation of a mental test score for assesment of mental impairment in the elderly. Age Ageing 1, 233-238.
22. Rocca, W.A., Bonaiuto, S., Lippi, A., Luciani, P., Pistarelli, T., Grandinetti, A., Cavarzeran, F. & Amaducci, L. (1992) Validation of the Hodkinson Abbreviated Mental Test as a screening instrument for dementia in an Italian population. Neuroepidemiology 11, 288-295
23. Jitapunkul, S., Pillay, I. & Ebrahim, S. (1991) The abbreviated mental test: its use and validity. Aqe Ageing 20, 332-336.
24. Harwood, D.M., Hope, T. & Jacoby, R. (1997) Cognitive impairment in medical inpatients. I: screening for dementia-is history better than mental state? Age Ageing 26, 31-35.
25. Pahor, M., Chrischilles, E.A., Guralnik, J.M., Brown, S.L., Wallace, R.B. & Carbonin, P.U. (1994) Drug data coding and analysis in epidemiologic studies. Eur. J. Epidemiol. 10. 405-411.
26. th edn., New York: McGraw-Hill, pp. 342-352.
27. th revision). Clinical modifications. Washington DC: PHS-HCF.
28. Glick, J.L. (1990) Dementias: the role of magnesium deficiency and an hypothesis concerning the pathogenesis of Alzheimer's disease. Med. Hypotheses 31, 211-225.
29. Korf, J., Grambsbergen, J.B.P., Prenen, G.H.M. & Go, K.G. (1986): Cation shifts and excitotoxins in Alzheimer and Huntington disease and experimental brain damage. Prog. Brain. Res. 70, 213-226.
30. Greenamyre, J.T., Penney, J.B., D'Amato, C.J. & Young, A.B. (1987) Dementia of the Alzheimer's type: changes in hippocampal 1-3H glutamate binding. J. Neurochem. 48, 543-551.
31. Durlach, J., Cordier, M.L., Cordier, J. & Fourdinier, L. (1973:) Étude de diverse correlations entre parametres psycometricues. neuro-physiologiques et ioniques au cours du deficit magnésique primitif de l'adulte. Rev. Franc. Endocrinol. Clin. 6, 447-454.
32. Hall, R.C.W. & Jaffe, J.R.L. (1973): Hypomagnesemia. Physical and psychiatrie symptoms. JAMA 224, 1749-1753.
33. Breteler, M.M., van Amerongen, N.M., van Swieten, J.C., Claus, J.J., Grobbee, D.E., van Gijn, J., Hofman, A. & van Harskamp, F. (1994) Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging. The Rotterdam Study. Stroke 25, 1109-1115.
34. Manolio, T.A., Kronmal, R.A., Burke, G.L., Poirier, V., O'Leary, D.H., Gardin, J.M., Fried, L.P., Steinberg, E.P. & Bryan, R.N. (1994) Magnetic resonance abnormalities and cardiovascular disease in older adults. The Cardiovascular Health Study. Stroke 25, 318-327.
35. Altura, B.T. & Altura, B.M. (1980) Withdrawal of magnesium causes vasospasm while elevated magnesium produces relaxation of tone in cerebral arteries. Neurosci. Lett. 20, 323-327.
36. Rayssiguier, Y., Gueux, E., Bussiere, L., Durlach, J. & Mazur, A. (1993) Dietary magnesium affects susceptibility of lipoproteins and tissues to peroxidation in rats. J. Am. Coll. Nutr. 12, 133-137.
37. Ma, J., Folsom, A.R., Melnick, S.L., Eckfeldt, J.H., Sharret, A.R., Nabulsi, A.A., Hutchinson, R.G. & Metcalf, P.A. Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid artery wall thickness: the ARIC study: Atherosclerosis Risk in Communities Study. J. Clin. Epidemiol. 48, 927-940.
38. Ascherio, A., Rimm. E.B., Hernan, M.A., Giovannucci, E.L., Kawachi, I., Stampfer, M.J. & Willett, W.C. (1998) Intake of potassium, magnesium, calcium and fiber and risk of stroke among US men. Circulation 98, 1198-1204.
39. Cattin, L., Bordin, P., Fonda, M., Adamo, C., Barbone, F., Bovenzi, M., Manto, A., Pedone, C. & Pahor, M., for the Gruppo Italiano di Farmacovigilanza nell'Anziano (GIFA) (1997): Factors associated with cognitive impairment among older italian inpatients. J. Am. Geriatr. Soc. 45, 1324-1330.
40. Weidmann, P., Bohlen, L. & de Courten, M. (1995) Insulin resistance and hyperinsulinemia in hypertension. J. Hypertens. 13 (suppl 2). S65-S72.
41. Kuusisto, J., Koivisto, K., Mykkanen, L., Helkala, E., Vanhanen, M., Hanninen, T., Pyorala, K., Riekkinen, P. & Laasko, M. (1993) Essential hypertension and cognitive function. The role of hyperinsulinemia. Hypertension 22, 771-779.
42. Ford, E.S. (1998) Race, education, and dietary cations: findings from the Third National Health and Nutrition Examination Survey. Ethn. Dis. 8. 10-20.
43. Sheehan, J. & White, A. (1982) Diuretic associated hypomagnesemia. BMJ 285, 1157-1159.
44. Zuccalà, G., Pedone, C., Cocchi, A., Pahor, M., Carosella, L., Carbonin, P. & Bernabei, R. (2000) Older age and in hospital development of hypokalemia from diuretics: results from a multicenter survey. GIFA investigators. Multicenter Italian Pharmacoepidemiologic Study Group. J. Gerontol. Biol. Sci. Med. Sci. 55, M232-M238.
45. Greenberg, A. (2000) Diuretic complications. Am. J. Med. Sci. 319, 10-24.
46. Landmark, K. (1985) Antihypertensive and metabolic effects of long-therapy with nifedipine slow release tablets. J. Cardiovasc. Pharmacol. 7, 12-17.
47. Giordano, M., Sanders, L.R., Castellino, P., Canessa, M.L. & DeFronzo, R.A. (1996) Effect of alpha-adrenergic blockers. ACE-inhibitors, and calcium channel antagonists on renal function in hypertensive non insulin dependent diabetic patients. Nephron 72, 447-453.
48. Forette, F., Seux, M.L., Staessen, J.A., Thijs, L., Birkenhager, W.H., Babarskiene, M.R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., Laks, T., Lilov, E., Moisseyev, V., Tuomilehto. J., Vanhanen, H., Webster, J., Yodfat, Y. & Fagard, R. (1998) Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial. Lancet 352, 1347-1351.
49. Millart, H., Durlach, V. & Durlach, J. (1995) Red blood cell magnesium concentrations: analytical problems and significance. Magnes. Res. 8, 65-76.
50. Hennekens, C.H. & Buring, J.E. (1987): Epidemiology in medicine. Boston/Toronto: Little, Brown & Co. 1987.
51. Durlach, J. (1995) Editorial policy of Magnesium Research: general considerations on the quality criteria for biomedical papers and some complementary guidelines for the contributors of Magnesium Research. Magnes. Res. 8, 191-206.