N-acetylcysteine treatment prevents the up-regulation of MnSOD in chronically hypoxic rat hearts

Physiological Research

Volumn 60, Issue 3, 2011, Pages 467-474

  Balkova P ^a,c   Hlavackova M ^a   Milerova M ^b,c   Neckar J ^b,c   Kolar F ^b,c   Novak F ^a,c   Novakova O ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c Center for Cardiovascular Research   (Czech Republic)

Author keywords

Cardioprotection; Chronic hypoxia; Ischemia reperfusion; MnSOD; Myocardial infarction

Indexed keywords

EID: 79960949505     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: 10.33549/physiolres.932042     Document Type: Article

References (41)

1. BARREIRO E, SANCHEZ D, GALDIZ JB, HUSSAIN SN, GEA J: N-acetylcysteine increases manganese superoxide dismutase activity in septic rat diaphragms. Eur Respir J 26: 1032-1039, 2006.
2. BOLLI R: The late phase of preconditioning. Circ Res 87: 972-983, 2000.
3. BORGER DR, ESSIG DA: Induction of HSP 32 gene in hypoxic cardiomyocytes is attenuated by treatment with Nacetyl-L-cysteine. Am J Physiol 274: H965-H973, 1998.
4. CHEN CH, LIU K, CHAN JY: Anesthetic preconditioning confers acute cardioprotection via up-regulation of manganese superoxide dismutase and preservation of mitochondrial respiratory enzyme activity. Shock 29: 300-308, 2008.
5. CHEN Z, SIU B, HO YS, VINCENT R, CHUA CC, HAMDY RC, CHUA BH: Overexpression of MnSOD protects against myocardial ischemia/reperfusion injury in transgenic mice. Mol Cell Cardiol 30: 2281-2289, 1998.
6. DAS DK, MAULIK N, MORARU II: Gene expression in acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress. J Mol Cell Cardiol 27: 181-193, 1995.
7. DAS KC, GUO XL, WHITE CW: Protein kinase C-δ dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs. J Biol Chem 273: 34639-34645, 1998.
8. ELSTNER EF, YOUNGMAN RJ, OBWALD W: Superoxide dismutase. In: Methods of Enzymatic Analysis, vol. III. BERGMEYER HU (ed), Verlag Chemie, Weinheim, 1983, pp 293-302.
9. HAMILTON KL, POWERS SK, SUGIURA T, KIM S, LENNON S, TUMER N, MEHTA JL: Short-term exercise training can improve myocardial tolerance to I/R without elevation in heat shock proteins. Am J Physiol Heart Circ Physiol 281: H1346-H1352, 2001.
10. HOSHIDA S, YAMASHITA N, OTSU K, HORI M: Repeated physiologic stresses provide persistent cardioprotection against ischemia-reperfusion injury in rats. J Am Coll Cardiol 40: 826-831, 2002.
11. HUSSAIN SP, AMSTAD P, HE P, ROBLES A, LUPOLD S, KANEKO I, ICHIMIYA M, SENGUPTA S, MECHANIC L, OKAMURA S, HOFSETH LJ, MOAKE M, NAGASHIMA M, FORRESTER KS, HARRIS CC: p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis. Cancer Res 64: 2350-2356, 2004.
12. JEŽKOVÁ J, NOVÁKOVÁ O, KOLÁŘ F, TVRZICKÁ E, NECKÁŘ J, NOVÁK F: Chronic hypoxia alters fatty acid composition of phospholipids in right and left ventricular myocardium. Mol Cell Biochem 232: 49-56, 2002.
13. KININGHAM KK, DAOSUKHO C, CLAIR DK: IκBα (inhibitory κBα) identified as labile repressor of MnSOD (manganese superoxide dismutase) expression. Biochem J 384: 543-549, 2004.
14. KOLÁŘ F, OŠŤÁDAL B: Molecular mechanisms of cardiac protection by adaptation to chronic hypoxia. Physiol Res 53 (Suppl 1): S3-S13, 2004.
15. KOLÁŘ F, JEŽKOVÁ J, BALKOVÁ P, BŘEH J, NECKÁŘ J, NOVÁK F, NOVÁKOVÁ O, TOMÁŠOVÁ H, SRBOVÁ M, OŠŤÁDAL B, WILHELM J, HERGET J: Role of oxidative stress in PKC-δ upregulation and cardioprotection induced by chronic intermittent hypoxia. Am J Physiol Heart Circ Physiol 292: H224-H230, 2007.
16. LAM SY, TIPOE GL, LIONG EC, FUNG ML: Chronic hypoxia upregulates the expression and function of proinflammatory cytokines in the rat carotid body. Histochem Cell Biol 130: 549-559, 2008.
17. LECOUR S, OWIRA P, OPIE LH: Ceramide-induced preconditioning involves reactive oxygen species. Life Sci 78: 1702-1706, 2006.
18. LI JJ, OBERLEY LW, FAN M, COLBURN NH: Inhibition of AP-1 and NF-κB by manganese-containing superoxide dismutase in human breast cancer cells. FASEB J 12: 1713-1723, 1998.
19. LI Y, HUANG TT, CARLSON EJ, MELOV S, URSELL PC, OLSON JL, NOBLE LJ, YOSHIMURA MP, BERGER C, CHAN PH, WALLACE DC, EPSTEIN CJ: Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11: 376-381, 1995.
20. LIU X, ENGELMAN RM, MORARU II, ROUSOU JA, FLACK JE 3rd, DEATON DW, MAULIK N, DAS DK: Heat shock. A new approach for myocardial preservation in cardiac surgery. Circulation 86: 358-363, 1992.
21. MACMILLAN-CROW LA, THOMPSON JA: Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys 366: 82-88, 1999.
22. MASUDA A, LONGO DL, KOBAYASHI Y, APPELLA E, OPPENHEIM JJ, MATSUSHIMA K: Induction of mitochondrial manganese superoxide dismutase by interleukin 1. FASEB J 15: 3087-3091, 1988.
23. MCCORD JM, FRIDOVICH I: Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244: 6049-6055, 1969.
24. MENON SG, SARSOUR EH, KALEN AL, VENKATARAMAN S, HITCHLER MJ, DOMANN FE, OBERLEY LW, GOSWAMI PC: Superoxide signaling mediates N-acetyl-L-cysteine-induced G1 arrest: regulatory role of cyclin D1 and manganese superoxide dismutase. Cancer Res 67: 6392-6399, 2007.
25. NAVARRO-ANTOLIN J, REDONDO-HORCAJO M, ZARAGOZA C, ALVAREZ-BARRIENTOS A, FERNANDEZ AP, LEON-GOMEZ E, RODRIGO J, LAMAS S: Role of peroxynitrite in endothelial damage mediated by Cyclosporine A. Free Radic Biol Med 42: 394-403, 2007.
26. NOUETTE-GAULAIN K, MALGAT M, ROCHER C, SAVINEAU JP, MARTHAN R, MAZAT JP, SZTARK F: Time course of differential mitochondrial energy metabolism adaptation to chronic hypoxia in right and left ventricles. Cardiovasc Res 66: 132-140, 2005.
27. OBERLEY LW, CLAIR DK, AUTOR AP, OBERLEY TD: Increase in manganese superoxide dismutase activity in the mouse heart after X-irradiation. Arch Biochem Biophys 254: 69-80, 1987.
28. OH C, DONG Y, LIU H, THOMPSON LP: Intrauterine hypoxia upregulates proinflammatory cytokines and matrix metalloproteinases in fetal guinea pig hearts. Am J Obstet 199: 1-6, 2008.
29. PETERSON GL: A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal Biochem 83: 346-356, 1977.
30. RAHA S, MCEACHERN GE, MYINT AT, ROBINSON BH: Superoxides from mitochondrial complex III: the role of manganese superoxide dismutase. Free Radic Biol Med 29: 170-180, 2000.
31. ROGERS RJ, MONNIER JM, NICK HS: Tumor necrosis factor α selectively induces MnSOD expression via mitochondria-to-nucleus signaling, whereas interleukin-1β utilizes an alternative pathway. Biol Chem 276: 20419-20427, 2001.
32. SPITZ DR, OBERLEY LW: An assay for superoxide dismutase activity in mammalian tissue homogenates. Anal Biochem 179: 8-18, 1989.
33. STARKOV AA: The role of mitochondria in reactive oxygen species metabolism and signaling. Ann NY Acad Sci 1147: 37-52, 2008.
34. STORZ P, DÖPPLER H, TOKER A: Protein kinase D mediates mitochondrion-to-nucleus signaling and detoxification from mitochondrial reactive oxygen species. Mol Cell Biol 19: 8520-8530, 2005.
35. SUZUKI K, MURTUZA B, SAMMUT IA, LATIF N, JAYAKUMAR J, SMOLENSKI RT, KANEDA Y, SAWA Y, MATSUDA H, YACOUB MH: Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction. Circulation 106: I270-I276, 2002.
36. VOOS W, GAMBILL BD, GUIARD B, PFANNER N, CRAIG EA: Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. J Cell Biol 123: 119-126, 1993.
37. WISPE JR, CLARK JC, BURHANS MS, KROPP KE, KORFHAGEN TR, WHITSETT JA: Synthesis and processing of the precursor for human mangano-superoxide dismutase. Biochim Biophys Acta 994: 30-36, 1989.
38. WONG GHW, GOEDDEL DV: Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 242: 941-944, 1988.
39. XIA Z, GUO Z, NAGAREDDY PR, YUEN V, YEUNG E, MCNEILL JH: Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats. Eur J Pharmacol 544: 118-125, 2006.
40. YAMASHITA N, HOSHIDA S, OTSU K, ASAHI M, KUZUYA T, HORI M: Exercise provides direct biphasic cardioprotection via manganese superoxide dismutase activation. J Exp Med 189: 1699-1706, 1999.
41. ZHU WZ, DONG JW, DING HL, YANG HT, ZHOU ZN: Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats. Eur J Appl Physiol 91: 716-722, 2004.