Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 6, 2011, Pages 3221-3227

  Pitcher III, John D ^a   De Paiva, Cintia S ^a   Pelegrino, Flavia S A ^a   McClellan, Andrew J ^a   Raince, Jagdeep K ^a   Pangelinan, Solherny B ^a   Rahimy, Ehsan ^a   Farley, William J ^a   Stern, Michael E ^b   Li, De Quan ^a   Pflugfelder, Stephen C ^a  

^a CULLEN EYE INSTITUTE   (United States)

^b ALLERGAN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; EPIDERMAL GROWTH FACTOR; GAMMA INTERFERON; GELATINASE B; GLYCOPROTEIN P 15095; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 23 RECEPTOR; INTERLEUKIN 6; MESSENGER RNA; MYELOPEROXIDASE; SCOPOLAMINE BROMIDE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR ALPHA; CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR BLOCKING AGENT; CYTOKINE; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CELL DENSITY; CERVICAL LYMPH NODE; CHOLINERGIC RECEPTOR BLOCKING; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GOBLET CELL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; LACRIMAL GLAND; LACRIMATION; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TH1 CELL; TH17 CELL; TH2 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL COUNT; CELL MOTION; DRUG EFFECT; GENETICS; IMMUNOLOGY; LACRIMAL APPARATUS; LACRIMAL FLUID; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL MOVEMENT; CHOLINERGIC ANTAGONISTS; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMAL GROWTH FACTOR; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INJECTIONS, SUBCUTANEOUS; LACRIMAL APPARATUS; MICE; MICE, INBRED C57BL; RECEPTORS, CHOLINERGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCOPOLAMINE; TEARS;

EID: 79960945075     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-4212     Document Type: Article

References (35)

1. Mircheff AK. Lacrimal gland fluid and electrolyte secretion: a review. Curr Eye Res. 1989;6:607-617.
2. Botelho SY. Tears and the lacrimal gland. Sci Am. 1964;211:78-86.
3. Hodges RR, Dartt DA. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol. 2003;231:129-196.
4. Helmick CG, Felson DT, Lawrence RC, et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I. Arthritis Rheum. 2008;58(1):15-25.
5. Fox RI, Törnwall J, Michelson P. Current issues in the diagnosis and treatment of Sjögren's syndrome. Curr Opin Rheumatol. 1999;11:364-371.
6. Kassan SS, Moutsopoulos HM. Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004;164(12): 1275-1284.
7. Xanthou G, Tapinos NI, Polihronis M, et al. CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjögren's syndrome. Clin Exp Immunol. 1999;118:154-163.
8. Fox RI, Robinson CA, Curd JG, Kozin F, Howell FV. Sjögren's syndrome. Proposed criteria for classification. Arthritis Rheum. 1986;29(5):577-585.
9. Bacman S, Perez Leiros C, Sterin-Borda L, Hubscher O, Arana R, Borda E. Autoantibodies against lacrimal gland M3 muscarinic acetylcholine receptors in patients with primary Sjögren's syndrome. Invest Ophthalmol Vis Sci. 1998;39(1):151-156.
10. Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren's syndrome. Arthritis Rheum. 2000;43: 1647-1654.
11. Nakamura M, Tada Y, Akaishi T, Nakata K. M3 muscarinic receptor mediates regulation of protein secretion in rabbit lacrimal gland. Curr Eye Res. 1997;16:614-619.
12. Matsui M, Motomura D, Karasawa H, et al. Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype. Proc Natl Acad Sci USA. 2000;97:9579-9584.
13. Zoukhri D, Hodges RR, Byon D, Kublin CL. Role of proinflammatory cytokines in the impaired lacrimation associated with autoimmune xerophthalmia. Invest Ophthalmol Vis Sci. 2002;43(5): 1429-1436.
14. Toshida H, Nguyen D, Beuerman RW, Murakami A. Evaluation of novel dry eye model: preganglionic parasympathetic denervation in rabbit. Invest Ophthalmol Vis Sci. 2007;48(10):4468-4475.
15. Nguyen DH, Toshida H, Schurr J, et al. Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiol Genomics. 2004;18:108-118.
16. Nguyen DH, Vadlamudi V, Toshida H, Beuerman RW. Loss of parasympathetic innervation leads to sustained expression of proinflammatory genes in the rat lacrimal gland. Auton Neurosci. 2006;124(1-2):81-89.
17. Viau S, Maire MA, Pasquis B, et al. Time course of ocular surface and lacrimal gland changes in a new scopolamine-induced dry eye model. Graefes Arch Clin Exp Ophthalmol. 2008;246(6):857-867.
18. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002;43:632-638.
19. Stewart P, Chen Z, Farley W, Olmos L, Pflugfelder SC. Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005;31(4):175-178.
20. De Paiva CS, Corrales RM, Villareal AL, et al. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006; 47:2847-2856.
21. van Setten GB, Viinikka L, Tervo T, Pesonen K, Tarkkanen A, Perheentupa J. Epidermal growth factor is a constant component of normal human tear fluid. Graefes Arch Clin Exp Ophthalmol. 1989;227(2):184-187.
22. Ohashi Y, Ishida R, Kojima T, et al. Abnormal protein profiles in tears with dry eye syndrome. Am J Opthalmol. 2003;136(2):291-299.
23. Lam H, Bleiden L, De Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophtalmol. 2009;147:198-205.
24. Bacman S, Berra A, Sterin-Borda L, Borda E. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren syndrome. Invest Ophthalmol Vis Sci. 2001;42:321-327.
25. Robinson CP, Brayer J, Yamachika S, et al. Transfer of human serum IgG to nonobese diabetic Igmu null mice reveals a role for autoantibodies in the loss of secretory function of exocrine tissues in Sjögren's syndrome. Proc Natl Acad Sci USA. 1998;95:7538-7543.
26. Mircheff AK,. J Xie, L Qian, Hamm-Alvarez SF. Diverse perturbations may alter the lacrimal acinar cell autoantigenic spectra. DNA Cell Biol. 2002;21:435-442.
27. Heigle TJ, Pflugfelder SC. Aqueous tear production in patients with neurotrophic keratitis. Cornea. 1996;15:135-138.
28. Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance and the ocular surface. Ophthalmol. 2001;108:1230-1235.
29. Rao KV, Leveque C, Pflugfelder SC. Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. Br J Ophthalmol. 2010;51:844-849.
30. Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL. Gammadelta T cells: an important source of IL-17. Curr Opin Immunol. 2008;20(3):353-357.
31. Cha S, Brayer J, Gao J, et al. A dual role for interferon-gamma in the pathogenesis of Sjögren's syndrome-like autoimmune exocrinopathy in the nonobese diabetic mouse. Scand J Immunol. 2004; 60(6):552-565.
32. Brayer JB, Cha S, Nagashima H, et al. IL-4-dependent effector phase in autoimmune exocrinopathy as defined by the NOD. IL-4-gene knockout mouse model of Sjögren's syndrome. Scand J Immunol. 2001;54(1-2):133-140.
33. Jabs DA, Lee B, Whittum-Hudson JA, Prendergast RA. Th1 versus Th2 immune responses in autoimmune lacrimal gland disease in MRL/Mp mice. Invest Ophthalmol Vis Sci. 2000;41(3):826-831.
34. Jabs DA, Prendergast RA, Rorer EM, Hudson AP, Whittum-Hudson JA. Cytokines in autoimmune lacrimal gland disease in MRL/MpJ mice. Invest Opthalmol Vis Sci. 2001;42(11):2567-2571.
35. Akpek EK, Jabs DA, Gérard HC, Prendergast RA, Hudson AP, Lee B, Whittum-Hudson JA. Chemokines in autoimmune lacrimal gland disease in MRL/MpJ mice. Invest Opthalmol Vis Sci. 2004;45(1): 185-190.