Abundant variations of MC4R gene revealed by Phylogenies of Yak (Bos grunniens) and other mammals

Molecular Biology Reports

Volumn 38, Issue 4, 2011, Pages 2733-2738

  Cai, Xin ^c   Mipam, Tserang Donko ^a   Zhang, Hairong ^b   Yue, Bisong ^c  

^a SOUTHWEST UNIVERSITY FOR NATIONALITIES   (China)

^b DEZHOU UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

Bos grunniens; Mammals; MC4R gene; Phylogenetic variations

Indexed keywords

AMINO ACID SEQUENCE; ARTICLE; BOS GRUNNIENS; BOS TAURUS; BOVIDS; CLADISTICS; CONTROLLED STUDY; GENE; GENE SEQUENCE; GENETIC CONSERVATION; GENETIC VARIABILITY; HAPLOTYPE; MC4R GENE; MOLECULAR CLONING; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OVIS ARIES; PHYLOGENY; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE; YAK; ANIMAL; BODY WEIGHT; CATTLE; CLUSTER ANALYSIS; COMPARATIVE STUDY; DNA SEQUENCE; GENETICS; MOLECULAR EVOLUTION; MOLECULAR GENETICS; MUTATION;

ANIMALIA; BOS GRUNNIENS; BOS TAURUS; BOVIDAE; MAMMALIA; OVIS ARIES; VERTEBRATA;

MELANOCORTIN 4 RECEPTOR; PRIMER DNA;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BODY WEIGHT; CATTLE; CLONING, MOLECULAR; CLUSTER ANALYSIS; DNA PRIMERS; EVOLUTION, MOLECULAR; GENETIC VARIATION; HAPLOTYPES; MOLECULAR SEQUENCE DATA; MUTATION; OPEN READING FRAMES; PHYLOGENY; RECEPTOR, MELANOCORTIN, TYPE 4; SEQUENCE ANALYSIS, DNA;

EID: 79960941214     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0418-2     Document Type: Article

References (18)

1. Seeley RJ, Drazen DL, Clegg DJ (2004) The critical role of the Melanocortin system in the control of energy balance. Ann Rev Nutr 24:133-149
2. Mountjoy KG, Mortrud MT, Low MJ et al (1994) Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8:1298-1308
3. Gantz I, Miwa H, Konda Y et al (1993) Molecular cloning, expression, and gene localization of fourth melanocortin receptor. J Biol Chem 268:15174-15179
4. Pérusse L, Rankinen T, Zuberi A et al (2005) The human obesity gene map: the 2004 update. Obes Res 13:381-490
5. Kim KS, Larsen N, Short T et al (2000) A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome 11: 131-135
6. Houston RD, Cameron ND, Rance KA (2004) A melanocortin-4 receptor (MC4R) polymorphism is associated with performance traits in divergently selected large white pig populations. Anim Genet 35:386-390
7. Jokubka R, Maak S, Kerziene S et al (2006) Association of a melanocortin 4 receptor (MC4R) polymorphism with performance traits in Lithuanian White pigs. J Anim Breed Genet 123:17-22
8. Zhang CL, Wang YH, Chen H et al (2009) Association between variants in the 50-untranslated region of the bovine MC4R gene and two growth traits in Nanyang cattle. Mol Biol Rep 36: 1839-1843
9. Staübert C, Tarnow P, Brumm H et al (2007) Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 148:4642-4648
10. Hughes DA, Hinney A, Brumm H et al (2009) Increased constraints on MC4R during primate and human evolution. Hum Genet 124:633-647
11. Thompson JD, Gibson TJ, Plewniak F et al (1997) The Clustal X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tool. Nucleic Acids Res 25:4876-4882
12. Kumar S, Dudley J, Nei M et al (2008) MEGA: a biologistcentric software for evolutionary analysis of DNA and protein sequences. Brief Bioinform 9:299-306
13. Librado P, Rozas J (2009) DnaSP v5: a software for comprehensive analysis of DNA polymorphism data. Bioinformatics 25:1451-1452
14. Felsenstein J (1988) Phylogenies from molecular sequences: inference and reliability. Ann Rev Genet 22:521-565
15. Bandelt H, Forster P, Rohl A (1999) Median joining networks for inferring intraspecific phylogenies. Mol Biol Evol 16:37-48
16. Tu ZC, Qiu H, Zhang YP (2002) Polymorphism in mitochondrial DNA (mtDNA) of Yak (Bos grunniens). Biochem Genet 40:187-193
17. Skorczyk A, Stachowiak M, Szczerbal I et al (2007) Polymorphism and chromosomal location of the MC4R (melanocortin-4 receptor) gene in the dog and red fox. Gene 392:247-252
18. Butler AA, Cone RD (2003) Knockout studies defining different roles for melanocortin receptors in energy homeostasis. Ann NY Acad Sci 994:240-245