Epistatic relationships in the BRCA1-BRCA2 pathway

PLoS Genetics

Volumn 7, Issue 7, 2011, Pages

  Scully, Ralph ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; PROTEIN P53; RAD51 PROTEIN;

ALLELE; ARTICLE; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE ARREST; CELL VIABILITY; CHROMATID ABERRATION; CHROMOSOME BREAKAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENE; GENE CONTROL; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC EPISTASIS; GENETIC RISK; HOMOLOGOUS RECOMBINATION; HUMAN; MOLECULAR PHYLOGENY; NONHUMAN; ONCOGENE; OVARY CANCER; PHENOTYPE; RAD51 GENE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; ANIMAL; GENETICS; NOTE;

ANIMALS; BRCA2 PROTEIN; EPISTASIS, GENETIC; HOMOLOGOUS RECOMBINATION; RAD51 RECOMBINASE;

EID: 79960937644     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002183     Document Type: Article

References (5)

1. Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A, (1997) Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev 11: 1226-1241.
2. Bouwman P, Aly A, Escandell JM, Pieterse M, Bartkova J, et al. (2010) 53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers. Nat Struct Mol Biol 17: 688-695.
3. Bunting SF, Callen E, Wong N, Chen HT, Polato F, et al. (2010) 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell 141: 243-254.
4. Qing Y, Yamazoe M, Hirota K, Dejsuphong D, Sakai W, et al. (2011) The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination. PLoS Genet 7: e1002148 doi:10.1371/journal.pgen.1002148.
5. Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O, Shinohara A, et al. (1998) Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. Embo J 17: 598-608.