Identification of the nephropathy-susceptibility locus HIVAN4

Journal of the American Society of Nephrology

Volumn 22, Issue 8, 2011, Pages 1497-1504

  Prakash, Sindhuri ^a   Papeta, Natalia ^a   Sterken, Roel ^a   Zheng, Zongyu ^a   Thomas, Robert L ^b   Wu, Zhenzhen ^b   Sedor, John R ^b   D'Agati, Vivette D ^a   Bruggeman, Leslie A ^b   Gharavi, Ali G ^a  

^a Russ Berrie Pavilion ^*  (United States)

^b METROHEALTH MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT;

A2M GENE; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 2; CHROMOSOME 6; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCATION; GENE LOCUS; GLOMERULUS; HIVAN4 GENE; HUMAN IMMUNODEFICIENCY VIRUS 1; KIDNEY DISEASE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; NPSH2 GENE; PRIORITY JOURNAL; PROTEIN INTERACTION; PTPRO GENE; QUANTITATIVE TRAIT LOCUS; SCORING SYSTEM;

EID: 79960931108     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011020209     Document Type: Article

References (36)

1. Wyatt CM, Klotman PE: HIV-1 and HIV-associated nephropathy 25 years later. Clin J Am Soc Nephrol 2: S20-24, 2007
2. Freedman BI, Soucie JM, Stone SM, Pegram S: Familial clustering of end-stage renal disease in blacks with HIV-associated nephropathy. Am J Kidney Dis 34: 254-258, 1999 (Pubitemid 29362089)
3. Genovese G, Tonna SJ, Knob AU, Appel GB, Katz A, Bernhardy AJ, Needham AW, Lazarus R, Pollak MR: A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9. Kidney Int 78: 698-704, 2010
4. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR: Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science 329: 841-845, 2010
5. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR: The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol 21: 1422-1426, 2010
6. Kopp JB, Klotman ME, Adler SH, Bruggeman LA, Dickie P, Marinos NJ, Eckhaus M, Bryant JL, Notkins AL, Klotman PE: Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci U S A 89: 1577-1581, 1992
7. Rosenstiel P, Gharavi A, D'Agati V, Klotman, P. Transgenic and infectious animal models of HIV-associated nephropathy. J Am Soc Nephrol 20: 2296-2304, 2009
8. Bruggeman LA, Nelson PJ: Controversies in the pathogenesis of HIV-associated renal diseases. Nat Rev Nephrol 5: 574-581, 2009
9. Albaqumi M, Soos TJ, Barisoni L, Nelson PJ: Collapsing glomerulopathy. J Am Soc Nephrol 17: 2854-2863, 2006 (Pubitemid 44484675)
10. Bruggeman LA, Adler SH, Klotman PE: Nuclear factor-kappa B binding to the HIV-1 LTR in kidney: Implications for HIV-associated nephropathy. Kidney Int 59: 2174-2181, 2001 (Pubitemid 32467609)
11. Ross MJ, Martinka S, D'Agati VD, Bruggeman LA: NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J Am Soc Nephrol 16: 2403-2411, 2005 (Pubitemid 41725058)
12. He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE: Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest 114: 643-651, 2004 (Pubitemid 39578754)
13. Lu TC, Wang ZH, Feng X, Chuang PY, Fang W, Shen Y, Levy DE, Xiong H, Chen N, He JC: Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy. Kidney Int 76: 63-71, 2009
14. Ray PE, Bruggeman LA, Weeks BS, Kopp JB, Bryant JL, Owens JW, Notkins AL, Klotman PE: bFGF and its low affinity receptors in the pathogenesis of HIV-associated nephropathy in transgenic mice. Kidney Int 46: 759-772, 1994 (Pubitemid 24272034)
15. Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, Klotman PE, He JC: HIV-1 upregulates VEGF in podocytes. J Am Soc Nephrol 19: 877-883, 2008
16. Bruggeman LA, Drawz PE, Kahoud N, Lin K, Barisoni L, Nelson PJ: TNFR2 interposes the proliferative and NF-kappaB-mediated inflammatory response by podocytes to TNF-alpha. Lab Invest 91: 413-425, 2011
17. Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, Frankel RZ, Bruggeman LA, D'Agati VD, Klotman PE, Lifton RP: Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci U S A 101: 2488-2493, 2004 (Pubitemid 38269338)
18. Papeta N, Chan KT, Prakash S, Martino J, Kiryluk K, Ballard D, Bruggeman LA, Frankel R, Zheng Z, Klotman PE, Zhao H, D'Agati VD, Lifton RP, Gharavi AG: Susceptibility loci for murine HIV-associated nephropathy encode transregulators of podocyte gene expression. J Clin Invest 119: 1178-1188, 2009
19. Chan KT, Papeta N, Martino J, Zheng Z, Frankel RZ, Klotman PE, D'Agati VD, Lifton RP, Gharavi AG: Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus. Kidney Int 75: 366-372, 2009
20. Darvasi A: Experimental strategies for the genetic dissection of complex traits in animal models. Nat Genet 18: 19-24, 1998
21. Wade CM, Kulbokas EJ, 3rd, Kirby AW, Zody MC, Mullikin JC, Lander ES, Lindblad-Toh K, Daly MJ: The mosaic structure of variation in the laboratory mouse genome. Nature 420: 574-578, 2002 (Pubitemid 35477050)
22. Lee SH, Girard S, Macina D, Busa M, Zafer A, Belouchi A, Gros P, Vidal SM: Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet 28: 42- 45, 2001
23. Lee SH, Gitas J, Zafer A, Lepage P, Hudson TJ, Belouchi A, Vidal SM: Haplotype mapping indicates two independent origins for the Cmv1s susceptibility allele to cytomegalovirus infection and refines its localization within the Ly49 cluster. Immunogenetics 53: 501-505, 2001 (Pubitemid 32906990)
24. Delano ML, Brownstein DG: Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype. J Virol 69: 5875-5877, 1995
25. Idris AH, Smith HR, Mason LH, Ortaldo JR, Scalzo AA, Yokoyama WM: The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing. Proc Natl Acad Sci U S A 96: 6330- 6335, 1999
26. Parham P, Abi-Rached L, Matevosyan L, Moesta AK, Norman PJ, Older Aguilar AM, Guethlein LA: Primate-specific regulation of natural killer cells. J Med Primatol 39: 194-212, 2010
27. Barisoni L, Kriz W, Mundel P, & D'Agati, V.: The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 10: 51- 61, 1999
28. Wharram BL, Goyal M, Gillespie PJ, Wiggins JE, Kershaw DB, Holzman LB, Dysko RC, Saunders TL, Samuelson LC, Wiggins RC: Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. J Clin Invest 106: 1281-1290, 2000
29. Lindenmeyer MT, Eichinger F, Sen K, Anders HJ, Edenhofer I, Mattinzoli D, Kretzler M, Rastaldi MP, Cohen CD: Systematic analysis of a novel human renal glomerulus-enriched gene expression dataset. PLoS One 5: e11545, 2010
30. Meier UC, Billich A, Mann K, Schramm HJ, Schramm W: alpha 2-Macroglobulin is cleaved by HIV-1 protease in the bait region but not in the C-terminal inter-domain region. Biol Chem Hoppe Seyler 372: 1051-1056, 1991
31. Chua S, Jr., Li Y, Liu SM, Liu R, Chan KT, Martino J, Zheng Z, Susztak K, D'Agati VD, Gharavi AG: A susceptibility gene for kidney disease in an obese mouse model of type II diabetes maps to chromosome 8. Kidney Int 78: 453-462, 2010
32. Hageman RS, Leduc MS, Caputo CR, Tsaih SW, Churchill GA, Korstanje, R. Uncovering genes and regulatory pathways related to urinary albumin excretion. J Am Soc Nephrol 22: 73-81, 2011
33. Sheehan S, Tsaih SW, King BL, Stanton C, Churchill GA, Paigen B, DiPetrillo K: Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Am J Physiol Renal Physiol 293: F1649-1656, 2007 (Pubitemid 350086002)
34. Ratelade J, Lavin TA, Muda AO, Morisset L, Mollet G, Boyer O, Chen DS, Henger A, Kretzler M, Hubner N, Thery C, Gubler MC, Montagutelli X, Antignac C, Esquivel EL: Maternal environment interacts with modifier genes to influence progression of nephrotic syndrome. J Am Soc Nephrol 19: 1491-1499, 2008
35. Mottl AK, Vupputuri S, Cole SA, Almasy L, Goring HH, Diego VP, Laston S, Franceschini N, Shara NM, Lee ET, Best LG, Fabsitz RR, MacCluer JW, Umans JG, North KE: Linkage analysis of glomerular filtration rate in American Indians. Kidney Int 74: 1185-1191, 2008
36. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11: 241-247, 1995