Adoptive cell therapy using antigen-specific CD4-CD8- T regulatory cells to prevent autoimmune diabetes and promote islet allograft survival in NOD mice

Diabetologia

Volumn 54, Issue 8, 2011, Pages 2082-2092

  Zhang, D ^a,b   Zhang, W ^a,b   Ng, T W ^b   Wang, Y ^b   Liu, Q ^b   Gorantla, V ^b   Lakkis, F ^b   Zheng, X X ^b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

CD4 CD8 regulatory T cells; Cell therapy; Islet transplantation; NOD mouse; Type 1 diabetes

Indexed keywords

GLUTAMATE DECARBOXYLASE 65; RAPAMYCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD GLUCOSE MONITORING; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL THERAPY; CONTROLLED STUDY; DIABETES MELLITUS; FLOW CYTOMETRY; GRAFT SURVIVAL; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MONONUCLEAR CELL; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PHENOTYPE; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SPLEEN CELL; TREATMENT RESPONSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MICE; MICE, INBRED NOD; POLYMERASE CHAIN REACTION; T-LYMPHOCYTES, REGULATORY; TISSUE THERAPY;

EID: 79960928375     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2179-4     Document Type: Article

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