Peripheral Quantitative Computed Tomography: Optimization of Reproducibility Measures of Bone Density, Geometry, and Strength at the Radius and Tibia

Journal of Clinical Densitometry

Volumn 14, Issue 3, 2011, Pages 367-373

  Rinaldi, Giulia ^a,b   Wisniewski, Charles A ^b   Setty, Nithya G ^b   LeBoff, Meryl S ^b  

^a UNIVERSITY OF PADOVA   (Italy)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Bone geometry; Coefficient of variation; Least significant change; PQCT; Reproducibility; Strength indices

Indexed keywords

ADULT; ARTICLE; BONE DENSITY; BONE STRENGTH; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CORTICAL BONE; FEMALE; HUMAN; PRIORITY JOURNAL; RADIUS; TIBIA; TRABECULAR BONE; ULNA;

ADULT; BONE DENSITY; FEMALE; HUMANS; RADIUS; REPRODUCIBILITY OF RESULTS; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; YOUNG ADULT;

EID: 79960924555     PISSN: 10946950     EISSN: 15590747     Source Type: Journal    
DOI: 10.1016/j.jocd.2011.05.002     Document Type: Article

References (46)

1. Guglielmi G., Schneider P., Lang T.F., et al. Quantitative computed tomography at the axial and peripheral skeleton. Eur Radiol 1997, 7(10):32-42.
2. Augat P., Fuerst T., Genant H.K. Quantitative bone mineral assessment at the forearm: a review. Osteoporos Int 1998, 8(4):299-310.
3. Muller R., Hildebrand T., Hauselmann H.J., Ruegsegger P. In vivo reproducibility of three-dimensional structural properties of noninvasive bone biopsies using 3D-pQCT. J Bone Miner Res 1996, 11(11):1745-1750.
4. Marjanovic E.J., Ward K.A., Adams J.E. The impact of accurate positioning on measurements made by peripheral QCT in the distal radius. Osteoporos Int 2009, 20(7):1207-1214.
5. Sun L., Beller G., Felsenberg D. Quantification of bone mineral density precision according to repositioning errors in peripheral quantitative computed tomography (pQCT) at the radius and tibia. J Musculoskelet Neuronal Interact 2009, 9(1):18-24.
6. Shedd K.M., Hanson K.B., Alekel D.L., et al. Quantifying leisure physical activity and its relation to bone density and strength. Med Sci Sports Exerc 2007, 39(12):2189-2198.
7. Kontulainen S.A., Johnston J.D., Liu D., et al. Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis. J Musculoskelet Neuronal Interact 2008, 8(4):401-409.
8. Medizintechnik GnmH Stratec. XCT-3000 manual software version 6.0. Pforzheim, Germany: Medizintechnik GnmH Stratec, 38; 2004.
9. Kontulainen S., Liu D., Manske S., et al. Analyzing cortical bone cross-sectional geometry by peripheral QCT: comparison with bone histomorphometry. J Clin Densitom 2007, 10(1):86-92.
10. Engelke K., Adams J.E., Armbrecht G., et al. Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD Official Positions. J Clin Densitom 2008, 11(1):123-162.
11. Butz S., Wuster C., Scheidt-Nave C., et al. Forearm BMD as measured by peripheral quantitative computed tomography (pQCT) in a German reference population. Osteoporos Int 1994, 4(4):179-184.
12. Grampp S., Lang P., Jergas M., et al. Assessment of the skeletal status by peripheral quantitative computed tomography of the forearm: short-term precision in vivo and comparison to dual X-ray absorptiometry. J Bone Miner Res 1995, 10(10):1566-1576.
13. Ruegsegger P., Anliker M., Dambacher M. Quantification of trabecular bone with low dose computed tomography. J Comput Assist Tomogr 1981, 5(3):384-390.
14. Seitz P., Ruegsegger P., Gschwend N., Dubs L. Changes in local bone density after knee arthroplasty. The use of quantitative computed tomography. J Bone Joint Surg Br 1987, 69(3):407-411.
15. Muller A., Ruegsegger E., Ruegsegger P. Peripheral QCT: a low-risk procedure to identify women predisposed to osteoporosis. Phys Med Biol 1989, 34(6):741-749.
16. Laib A., Hauselmann H.J., Ruegsegger P. In vivo high resolution 3D-QCT of the human forearm. Technol Health Care 1998, 6(5-6):329-337.
17. Boutroy S., Bouxsein M.L., Munoz F., Delmas P.D. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005, 90(12):6508-6515.
18. Swinford R.R., Warden S.J. Factors affecting short-term precision of musculoskeletal measures using peripheral quantitative computed tomography (pQCT). Osteoporos Int 2010, 21(11):1863-1870.
19. Baim S., Wilson C.R., Lewiecki E.M., et al. Precision assessment and radiation safety for dual-energy X-ray absorptiometry: position paper of the International Society for Clinical Densitometry. J Clin Densitom 2005, 8(4):371-378.
20. Sievanen H., Koskue V., Rauhio A., et al. Peripheral quantitative computed tomography in human long bones: evaluation of in vitro and in vivo precision. J Bone Miner Res 1998, 13(5):871-882.
21. Braun M.J., Meta M.D., Schneider P., Reiners C. Clinical evaluation of a high-resolution new peripheral quantitative computerized tomography (pQCT) scanner for the bone densitometry at the lower limbs. Phys Med Biol 1998, 43(8):2279-2294.
22. Szabo K.A., Webber C.E., Gordon C., et al. Reproducibility of peripheral quantitative computed tomography measurements at the radius and tibia in healthy pre- and postmenopausal women. Can Assoc Radiol J 2010, [Epub ahead of print].
23. Muller M.E., Webber C.E., Bouxsein M.L. Predicting the failure load of the distal radius. Osteoporos Int 2003, 14(4):345-352.
24. Parfitt A.M. Implications of architecture for the pathogenesis and prevention of vertebral fracture. Bone 1992, (13 Suppl 2):S41-S47.
25. Takagi Y., Fujii Y., Miyauchi A., et al. Transmenopausal change of trabecular bone density and structural pattern assessed by peripheral quantitative computed tomography in Japanese women. J Bone Miner Res 1995, 10(11):1830-1834.
26. Martin R.B. Determinants of the mechanical properties of bones. J Biomech 1991, (24 Suppl 1):79-88.
27. Augat P., Reeb H., Claes L.E. Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 1996, 11(9):1356-1363.
28. Spadaro J.A., Werner F.W., Brenner R.A., et al. Cortical and trabecular bone contribute strength to the osteopenic distal radius. J Orthop Res 1994, 12(2):211-218.
29. Rockoff S.D., Sweet E., Bleustein J. The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae. Calcif Tissue Res 1969, 3(2):163-175.
30. McBroom R.J., Hayes W.C., Edwards W.T., et al. Prediction of vertebral body compressive fracture using quantitative computed tomography. J Bone Joint Surg Am 1985, 67(8):1206-1214.
31. Lotz J.C., Hayes W.C. The use of quantitative computed tomography to estimate risk of fracture of the hip from falls. J Bone Joint Surg Am 1990, 72(5):689-700.
32. Ashe M.C., Khan K.M., Kontulainen S.A., et al. Accuracy of pQCT for evaluating the aged human radius: an ashing, histomorphometry and failure load investigation. Osteoporos Int 2006, 17(8):1241-1251.
33. Nishiyama K.K., Macdonald H.M., Buie H.R., et al. Postmenopausal women with osteopenia have higher cortical porosity and thinner cortices at the distal radius and tibia than women with normal aBMD: an in vivo HR-pQCT study. J Bone Miner Res 2010, 25(4):882-890.
34. Taes Y., Lapauw B., Griet V., et al. Prevalent fractures are related to cortical bone geometry in young healthy men at age of peak bone mass. J Bone Miner Res 2010, 25(6):1433-1440.
35. Seeman E. Periosteal bone formation-a neglected determinant of bone strength. N Engl J Med 2003, 349(4):320-323.
36. Kontulainen S.A., Macdonald H.M., Khan K.M., McKay H.A. Examining bone surfaces across puberty: a 20-month pQCT trial. J Bone Miner Res 2005, 20(7):1202-1207.
37. Szulc P., Seeman E., Duboeuf F., et al. Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 2006, 21(12):1856-1863.
38. Vanderschueren D., Venken K., Ophoff J., et al. Clinical review: sex steroids and the periosteum-reconsidering the roles of androgens and estrogens in periosteal expansion. J Clin Endocrinol Metab 2006, 91(2):378-382.
39. van der Meulen M.C., Jepsen K.J., Mikic B. Understanding bone strength: size isn't everything. Bone 2001, 29(2):101-104.
40. Einhorn T.A. Bone strength: the bottom line. Calcif Tissue Int 1992, 51(5):333-339.
41. Siu W.S., Qin L., Leung K.S. pQCT bone strength index may serve as a better predictor than bone mineral density for long bone breaking strength. J Bone Miner Metab 2003, 21(5):316-322.
42. Hasegawa Y., Schneider P., Reiners C., et al. Estimation of the architectural properties of cortical bone using peripheral quantitative computed tomography. Osteoporos Int 2000, 11(1):36-42.
43. Lochmuller E.M., Lill C.A., Kuhn V., et al. Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 2002, 17(9):1629-1638.
44. Nelson L., Gulenchyn K.Y., Atthey M., Webber C.E. Is a fixed value for the least significant change appropriate?. J Clin Densitom 2010, 13(1):18-23.
45. Schneider P., Butz S., Allolio B., et al. Multicenter German reference data base for peripheral quantitative computer tomography. Technol Health Care 1995, 3(2):69-73.
46. Guglielmi G., De Serio A., Fusilli S., et al. Age-related changes assessed by peripheral QCT in healthy Italian women. Eur Radiol 2000, 10(4):609-614.