Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line

Molecular and Cellular Neuroscience

Volumn 48, Issue 1, 2011, Pages 20-28

  Sacchi, Silvia ^a,b   Cappelletti, Pamela ^a,b   Giovannardi, Stefano ^a   Pollegioni, Loredano ^a,b  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b POLITECNICO DI MILANO   (Italy)

Author keywords

D serine; Flavoprotein; Neurotransmission; NMDA receptor; Schizophrenia; Subcellular localization

Indexed keywords

DEXTRO AMINO ACID OXIDASE; DEXTRO SERINE; FLAVOPROTEIN; PROTEIN PLG72; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CELL LINE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; GENETIC TRANSFECTION; GLIA CELL; GLIOBLASTOMA; HUMAN; HUMAN CELL; MITOCHONDRION; NERVE CELL; NEUROTRANSMISSION; PEROXISOME; PLASMID; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TUMOR CELL; TUMOR CELL LINE;

ANIMALS; CARRIER PROTEINS; CELL FRACTIONATION; CELL LINE; D-AMINO-ACID OXIDASE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; MITOCHONDRIA; NEUROGLIA; PEROXISOMES; RECOMBINANT FUSION PROTEINS; SCHIZOPHRENIA;

PRIMATES;

EID: 79960917257     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2011.06.001     Document Type: Article

References (27)

1. Arnold G., Liscum L., Holtzman E. Ultrastructural localization of d-amino acid oxidase in microperoxisomes of the rat nervous system. J. Histochem. Cytochem. 1979, 27:735-745.
2. Baumgart F., Rodríguez-Crespo I. d-amino acids in the brain: the biochemistry of brain serine racemase. FEBS J. 2008, 275:3538-3545.
3. Bendikov I., Nadir S., Amar S., Panizzutti R., De Miranda J., Wolosker H., Agam G. A CSF and postmortem brain study of d-serine metabolic parameters in schizophrenia. Schizophr. Res. 2007, 90:41-51.
4. Benzel I., Kew J.N., Viknaraja R., Kelly F., de Belleroche J., Hirsch S., Sanderson T.H., Maycox P.R. Investigation of G72 (DAOA) expression in the human brain. BMC Psychiatry 2008, 8:94. 10.1186/1471-244X-8-94.
5. Bossi E., Soragna A., Misner A., Giovannardi S., Frangione V., Peres A. Oligomeric structure of the neutral amino acid transporter KAAT1 and CAATCH1. Am. J. Cell. Physiol. 2007, 292:379-387.
6. Caldinelli L., Molla G., Bracci L., Lelli B., Pileri S., Cappelletti P., Sacchi S., Pollegioni L. Effect of ligand binding on human d-amino acid oxidase: implications for the development of new drugs for schizophrenia treatment. Prot. Sci. 2010, 19:1500-1512.
7. Chumakov I., Blumenfeld M., Guerassimenko O., Cavarec L., Palicio M., Abderrahim H., Bougueleret L., Barry C., Tanaka H., La Rosa P., Puech A., Tahri N., Cohen-Akenine A., Delabrosse S., Lissarrague S., Picard F.P., Maurice K., Essioux L., Millasseau P., Grel P., Debailleul V., Simon A.M., Caterina D., Dufaure I., Malekzadeh K., Belova M., Luan J.J., Bouillot M., Sambucy J.L., Primas G., Saumier M., Boubkiri N., Martin-Saumier S., Nasroune M., Peixoto H., Delaye A., Pinchot V., Bastucci M., Guillou S., Chevillon M., Sainz-Fuertes R., Meguenni S., Aurich-Costa J., Cherif D., Gimalac A., Van Duijn C., Gauvreau D., Ouellette G., Fortier I., Raelson J., Sherbatich T., Riazanskaia N., Rogaev E., Raeymaekers P., Aerssens J., Konings F., Luyten W., Macciardi F., Sham P.C., Straub R.E., Weinberger D.R., Cohen N., Cohen D. Genetic and physiological data implicating the new human gene G72 and the gene for d-amino acid oxidase in schizophrenia. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:13675-13680.
8. Graham J. Biological Centrifugation 2001, 110. Taylor & Francis, Inc Ed.
9. Hashimoto K., Fukushima T., Shimizu E., Komatsu N., Watanabe H., Shinoda N., Nakazato M., Kumakiri C., Okada S., Hasegawa H., Imai K., Iyo M. Decreased serum levels of d-serine in patients with schizophrenia: evidence in support of the N-methyl-d-aspartate receptor hypofunction hypothesis of schizophrenia. Arch. Gen. Psychiatry 2003, 60:572-576.
10. Heresco-Levy U., Javitt D.C., Ebstein R., Vass A., Lichtenberg P., Bar G., Catinari S., Ermilov M. d-serine efficacy as add-on pharmacotherapy to risperidone and olanzapine for treatment-refractory schizophrenia. Biol. Psychiatry 2005, 57:577-585.
11. Insel T.R. Rethinking schizophrenia. Nature 2010, 468:187-193.
12. Kvajo M., Dhilla A., Swor D.E., Karayiorgou M., Gogos J.A. Evidence implicating the candidate schizophrenia/bipolar disorder susceptibility gene G72 in mitochondrial function. Mol. Psychiatry 2008, 13:685-696.
13. Labrie V., Roder J.C. The involvement of the NMDA receptor D-serine/glycine site in the pathophysiology and treatment of schizophrenia. Neurosci. Biobehav. Rev. 2010, 3:351-372.
14. Luo B., Norris C., Bolstad E.S., Knecht D.A., Grant D.F. Protein quaternary structure and expression levels contribute to peroxisomal-targeting-sequence-1-mediated peroxisomal import of human soluble epoxide hydrolase. J. Mol. Biol. 2008, 380:31-41.
15. Martineau M., Baux G., Mothet J.P. d-serine signalling in the brain: friend and foe. Trends Neurosci. 2006, 29:481-491.
16. Molla G., Sacchi S., Bernasconi M., Pilone M.S., Fukui K., Pollegioni L. Characterization of human d-amino acid oxidase. FEBS Lett. 2006, 580:2358-2364.
17. Molla G., Bernasconi M., Sacchi S., Pilone M.S., Pollegioni L. Expression in Escherichia coli and in vitro refolding of the human protein pLG72. Protein Expr. Purif. 2006, 46:150-155.
18. Moreno S., Nardacci R., Cimini A., Cerù M.P. Immunocytochemical localization of d-amino acid oxidase in rat brain. J. Neurocytol. 1999, 28:169-185.
19. Oliet S.H., Mothet J.P. Regulation of N-methyl-d-aspartate receptors by astrocytic d-serine. Neuroscience 2009, 158:275-283.
20. Pollegioni L., Sacchi S. Metabolism of the neuromodulator d-serine. Cell. Mol. Life Sci. 2010, 67:2387-2404.
21. Pollegioni L., Piubelli L., Sacchi S., Pilone M.S., Molla G. Physiological functions of d-amino acid oxidases: from yeast to humans. Cell. Mol. Life Sci. 2007, 64:1373-1394.
22. Sacchi S., Bernasconi M., Martineau M., Mothet J.P., Ruzzene M., Pilone M.S., Pollegioni L., Molla G. pLG72 modulates intracellular d-serine levels through its interaction with d-amino acid oxidase: effect on schizophrenia susceptibility. J. Biol. Chem. 2008, 283:22244-22256.
23. Schell M.J. The N-methyl d-aspartate receptor glycine site and d-serine metabolism: an evolutionary perspective. Philos. Trans. R. Soc. Lond. B Biol. Sci. 2004, 359:943-964.
24. Smith K. Neuroscience: settling the great glia debate. Nature 2010, 468:160-162.
25. Verrall L., Burnet P.W., Betts J.F., Harrison P.J. The neurobiology of d-amino acid oxidase and its involvement in schizophrenia. Mol. Psychiatry 2010, 15:122-137.
26. Wolosker H., Blackshaw S., Snyder S.H. Serine racemase: a glial enzyme synthesizing d-serine to regulate glutamate-N-methyl-d-aspartate neurotransmission. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:13409-13414.
27. Xia Z., Liu Y. Reliable and global measurement of fluorescence resonance energy transfer using fluorescence microscopes. Biophysical J. 2001, 81:2395-2402.