Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels

Journal of Molecular and Cellular Cardiology

Volumn 51, Issue 3, 2011, Pages 357-369

  Laver, Derek R ^a   van Helden, Dirk F ^a  

^a UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

Cardiac arrhythmia; Cardiac calcium release channel; Lipid bilayer; Ryanodine receptor; Tetracaine

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; RYANODINE RECEPTOR; TETRACAINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM CONDUCTANCE; CALCIUM TRANSPORT; CELL PH; CONTROLLED STUDY; CYTOPLASM; DIASTOLE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; IC 50; LIPID BILAYER; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN;

ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CYTOPLASM; HEART; HYDROGEN-ION CONCENTRATION; LIPID BILAYERS; MODELS, BIOLOGICAL; MYOCARDIUM; PROTEIN BINDING; SARCOPLASMIC RETICULUM; SHEEP; TETRACAINE;

OVIS ARIES;

EID: 79960898995     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.05.009     Document Type: Article

References (32)

1. Watanabe H., Chopra N., Laver D., Hwang H.S., Davies S.S., Roach D.E., et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med 2009, 15:380-383.
2. 2+ spark mass. J Mol Cell Cardiol 2010, 48:293-301.
3. Xu L., Jones R., Meissner G. Effects of local anesthetics on single channel behavior of skeletal muscle calcium release channel. J Gen Physiol 1993, 101:207-233.
4. Gyorke S., Lukyanenko V., Gyorke I. Dual effects of tetracaine on spontaneous calcium release in rat ventricular myocytes. J Physiol (Lond) 1997, 500:297-309.
5. Csernoch L., Szentesi P., Sarkozi S., Szegedi C., Jona I., Kovacs L. Effects of tetracaine on sarcoplasmic calcium release in mammalian skeletal muscle fibres. J Physiol (Lond) 1999, 515:843-857.
6. 2+ release channel of skeletal and cardiac muscles. Anesthesiology 1999, 90:835-843.
7. Shoshan-Barmatz V., Zchut S. The interaction of local anesthetics with the ryanodine receptor of the sarcoplasmic reticulum. J Membr Biol 1993, 133:171-181.
8. 2+ inhibits the ryanodine receptor from cardiac muscle. J Membr Biol 1995, 147:7-22.
9. ++-induced fusion of fragmented sarcoplasmic reticulum with artificial planar bilayers. Cell 1976, 9:283-300.
10. Hwang C., Sinskey A.J., Lodish H.F. Oxidized redox state of glutathione in the endoplasmic reticulum. Science 1992, 257:1496-1502.
11. Feng W., Liu G., Allen P.D., Pessah I.N. Transmembrane redox sensor of ryanodine receptor complex. J Biol Chem 2000, 275:35902-35907.
12. Marinov B.S., Olojo R.O., Xia R., Abramson J.J. Non-thiol reagents regulate ryanodine receptor function by redox interactions that modify reactive thiols. Antioxid Redox Signal 2007, 9:609-621.
13. Sies H. Glutathione and its role in cellular functions. Free Radic Biol Med 1999, 27:916-921.
14. O'Neill E.R., Sakowska M.M., Laver D.R. Regulation of the calcium release channel from skeletal muscle by suramin and the disulfonated stilbene derivatives DIDS, DBDS, and DNDS. Biophys J 2003, 84:1674-1689.
15. 2+ sites. Biophys J 2007, 92:3541-3555.
16. Sigworth F.J., Sine S.M. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophys J 1987, 52:1047-1054.
17. Laver D.R., Lenz G.K., Lamb G.D. Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine. J Physiol (Lond) 2001, 537:763-778.
18. Woodhull A.M. Ionic blockage of sodium channels in nerve. J Gen Physiol 1973, 61:708.
19. Chopra N., Laver D., Davies S.S., Knollmann B.C. Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release. Mol Pharmacol 2009, 75:183-195.
20. Tanna B., Welch W., Ruest L., Sutko J.L., Williams A.J. The interaction of a neutral ryanoid with the ryanodine receptor channel provides insights into the mechanisms by which ryanoid binding is modulated by voltage. J Gen Physiol 2000, 116:1-9.
21. Fodor A.A., Gordon S.E., Zagotta W.N. Mechanism of tetracaine block of cyclic nucleotide-gated channels. J Gen Physiol 1997, 109:3-14.
22. O'Brien J., Valdivia H.H., Block B.A. Physiological differences between the a and b ryanodine receptors of fish skeletal muscle. Biophys J 1995, 68:471-482.
23. 2+-release channels with monovalent cations as permeant species. Biophys J 1994, 67:1484-1494.
24. Sun J., Xu L., Eu J.P., Stamler J.S., Meissner G. Classes of thiols that influence the activity of the skeletal muscle calcium release channel. J Biol Chem 2001, 276:15625-15630.
25. 2+ release channel activity by phosphorylation of the skeletal muscle ryanodine receptor. FEBS Lett 1993, 332:237-242.
26. Coronado R., Morrissette J., Sukhareva M., Vaughan D.M. Structure and function of ryanodine receptors. Am J Physiol 1994, 266:C1485-C1504.
27. 2+ release channels and their regulation by endogenous effectors. Annu Rev Physiol 1994, 56:485-508.
28. Laver D.R., Baynes T.M., Dulhunty A.F. Magnesium inhibition of ryanodine-receptor calcium channels: evidence for two independent mechanisms. J Membr Biol 1997, 156:213-229.
29. 2+ transient in rat ventricular myocytes. Circ Res 2002, 91:585-593.
30. Eisner D.A., Kashimura T., O'Neill S.C., Venetucci L.A., Trafford A.W. What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis. J Mol Cell Cardiol 2009, 46:474-481.
31. 2+-sensitive leak in rat ventricular myocytes. Biophys J 2001, 81:785-798.
32. Samso M., Wagenknecht T., Allen P.D. Internal structure and visualization of transmembrane domains of the RyR1 calcium release channel by cryo-EM. Nat Struct Mol Biol 2005, 12:539-544.