Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases

Biochemical Society Transactions

Volumn 39, Issue 4, 2011, Pages 1092-1095

  Edwards, Alexander J P ^a   Pender, Sylvia L F ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Crohn's disease; Forkhead box P3 (Foxp3); Histone deacetylase; Inflammatory bowel disease; Ulcerative colitis

Indexed keywords

APICIDIN; BUTYRIC ACID; CYTOKINE; ENTINOSTAT; GAMMA INTERFERON; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 23; INTERLEUKIN 25; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; ROMIDEPSIN; TRANSFORMING GROWTH FACTOR BETA; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; VALPROIC ACID; VORINOSTAT;

ADAPTIVE IMMUNITY; AMINO TERMINAL SEQUENCE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL NUCLEUS; CHROMATIN; CHROMATIN CONDENSATION; CONFERENCE PAPER; CROHN DISEASE; CYTOKINE RELEASE; CYTOPLASM; DENDRITIC CELL; ENTERITIS; ENVIRONMENTAL FACTOR; FIBROBLAST; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HISTONE ACETYLATION; HUMAN; INNATE IMMUNITY; INTESTINE FLORA; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUALITY OF LIFE; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; ULCERATIVE COLITIS;

ANIMALS; GENE EXPRESSION REGULATION; HISTONE ACETYLTRANSFERASES; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HUMANS; INFLAMMATORY BOWEL DISEASES;

ANIMALIA;

EID: 79960880985     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0391092     Document Type: Conference Paper

References (25)

1. Schirbel, A. and Fiocchi, C. (2010) Inflammatory bowel disease: established and evolving considerations on its etiopathogenesis and therapy. J. Dig. Dis. 11, 266-276
2. Engel, M.A. and Neurath, M.F. (2010) New pathophysiological insights and modern treatment of IBD. J. Gastroenterol. 45, 571-583
3. Heuschkel, R.B., MacDonald, T.T., Monteleone, G., Bajaj-Elliott, M., Walker-Smith, J.A. and Pender, S.L.F. (2000) Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut 47, 57-62
4. Kamada, N., Hisamatsu, T., Okamoto, S., Chinen, H., Kobayashi, T., Sato, T., Sakuraba, A., Kitazume, M.T., Sugita, A., Koganei, K. et al. (2008) Unique CD14 intestinal macrophages contribute to the pathogenesis of Crohn's disease via IL-23/IFN-γ axis. J. Clin. Invest. 118, 2269-2280
5. Hart, A.L., Al-Hassi, H.O., Rigby, R.J., Bell, S.J., Emmanuel, A.V., Knight, S.C., Kamm, M.A. and Stagg, A.J. (2005) Characteristics of intestinal dendritic cells in inflammatory bowel disease. Gastroenterology 127, 300-309
6. MacDermott, R.P., Nash, G.S., Bertovich, M.J., Seiden, M.V., Bragdon, M.J. and Beale, M.G. (1986) Altered patterns of secretion of monomeric IgA and IgA subclass 1 by intestinal mononuclear cells in inflammatory bowel disease. Gastroenterology 91, 379-385 (Pubitemid 16098366)
7. Rutgeerts, P., Vermeire, S. and Van Assche, G. (2009) Biological therapies for inflammatory bowel diseases. Gastroenterology 136, 1182-1197
8. bright T cells in human intestinal lamina propria as regulatory cells. J. Immunol. 173, 3119-3130
9. +high T cells in inflammatory bowel disease. Gastroenterology 128, 1868-1878
10. Brimnes, J., Allez, M., Dotan, I., Shao, L., Nakazawa, A. and Mayer, L. (2005) Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J. Immunol. 174, 5814-5822 (Pubitemid 40593226)
11. Pender, S.L.F. and MacDonald, T.T. (2004) Matrix metalloproteinases and the gut: new roles for old enzymes. Curr. Opin. Pharmacol. 6, 546-550
12. Pender, S.L.F., Tickle, S.P., Docherty, A.J.P., Howie, D., Wathen, N.C. and MacDonald, T.T. (1997) A major role for matrix metalloproteinases in T cell injury in the gut. J. Immunol. 158, 1582-1590 (Pubitemid 127469511)
13. Hugot, J.P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C.A., Gassull, M. et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603 (Pubitemid 32531408)
14. Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R.H. et al. (2001) A frameshift mutation in NOD2 associated with a susceptibility to Crohn's disease. Nature 411, 603-606 (Pubitemid 32531409)
15. Gallinari, P., Di Marco, S., Jones, P., Pallaoro, M. and Steinkuhler, C. (2007) HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeutics. Cell Res. 17, 195-211 (Pubitemid 46438722)
16. Clayton, A., Hazzalin, C. and Mahadevan, L. (2006) Enhanced histone acetylation and transcription: a dynamic perspective. Mol. Cell 23, 289-296 (Pubitemid 44128853)
17. Longworth, M.S. and Laimins, L.A. (2006) Histone deacetylase 3 localises to the plasma membrane and is a substrate of Src. Oncogene 25, 4495-4500 (Pubitemid 44141638)
18. Waltregny, D., Glénisson, W., Tran, S.L., North, B.J., Verdin, E., Colige, A. and Castronovo, V. (2005) Histone deacetylase HDAC8 associates with smooth muscle α-actin and is essential for smooth muscle contractility. FASEB J. 19, 966-968 (Pubitemid 40827719)
19. Verdin, E., Dequiedt, F. and Kasler, H.G. (2003) Class II histone deacetylases: versatile regulators. Trends Genet. 19, 286-293 (Pubitemid 36507011)
20. Whittaker, S.J., Demierre, M.F., Kim, E.J., Rook, A.H., Lerner, A., Duvic, M., Scarisbrick, J., Reddy, S., Robak, T., Becker, J.C. et al. (2010) Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 29, 4485-4491
21. Glauben, R., Batra, A., Fedke, I., Zeitz, M., Lehr, H.A., Leoni, F., Mascagni, P., Fantuzzi, G., Dinarello, C.A. and Siegmund, B. (2006) Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J. Immunol. 176, 5015-5022
22. Tao, R., de Zoeten, E.F., Ozkaynak, E., Chen, C., Wang, L., Porrett, P.M., Li, B., Turka, L.A., Olson, E.N., Greene, M.I. et al. (2007) Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307
23. Glauben, R., Batra, A., Stroh, T., Erben, U., Fedke, I., Lehr, H.A., Leoni, F., Mascagni, P., Dinarello, C.A., Zeitz, M. and Siegmund, B. (2008) Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut 57, 613-622 (Pubitemid 351579973)
24. Pender, S.L., Quinn, J.J., Sanderson, I.R. and MacDonald, T.T. (2000) Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. Am. J. Physiol. Gastrointest. Liver Physiol. 279, 918-924
25. Edwards, A.J.P., Morgan-Walsh, R.J., Gwiggner, M., Claridge, A.G., Packham, G. and Pender, S.L. (2011) The role of HDAC inhibitors and proteasomes in a human ex-vivo model of IBD, http://www.biochemistry.org/Portals/0/ Conferences/abstracts/SA117/SA117P003.pdf (Abstract)