Immunohistochemical detection of a specific receptor for lipocalin2 (solute carrier family 22 member 17, SLC22A17) and its prognostic significance in endometrial carcinoma

Experimental and Molecular Pathology

Volumn 91, Issue 2, 2011, Pages 563-568

  Miyamoto, Tsutomu ^a   Asaka, Ryouichi ^a   Suzuki, Akihisa ^a   Takatsu, Akiko ^a   Kashima, Hiroyasu ^a   Shiozawa, Tanri ^a  

^a SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Endometrial carcinoma; Endometrium; Immunohistochemistry; Lipocalin2; SLC22A17

Indexed keywords

CARRIER PROTEIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; SOLUTE CARRIER FAMILY 22 MEMBER 17; UNCLASSIFIED DRUG;

ADNEXA DISEASE; ARTICLE; CANCER GRADING; CANCER INVASION; CANCER SURVIVAL; CONTROLLED STUDY; CYTOLOGY; ENDOMETRIUM CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; METASTASIS; MOLECULAR PATHOLOGY; PROGNOSIS; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE;

ACUTE-PHASE PROTEINS; ADULT; AGED; AGED, 80 AND OVER; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIPOCALINS; MIDDLE AGED; ORGANIC CATION TRANSPORT PROTEINS; PROGNOSIS; PROTO-ONCOGENE PROTEINS; SURVIVAL ANALYSIS;

EID: 79960879659     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2011.06.002     Document Type: Article

References (32)

1. Cho H., Kim J.H. Lipocalin2 expressions correlate significantly with tumor differentiation in epithelial ovarian cancer. J. Histochem. Cytochem. 2009, 57:513-521.
2. Cui L., Xu L.Y., Shen Z.Y., Tao Q., Gao S.Y., Lv Z., Du Z.P., Fang W.K., Li E.M. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma. Clin. Cancer Res. 2008, 14:7674-7681.
3. Devireddy L.R., Teodoro J.G., Richard F.A., Green M.R. Induction of apoptosis by a secreted lipocalin that is transcriptionally regulated by IL-3 deprivation. Science 2001, 293:829-834.
4. Devireddy L.R., Gazin C., Zhu X., Green M.R. A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell 2005, 123:1293-1305.
5. Du Z.P., Lv Z., Wu B.L., Wu Z.Y., Shen J.H., Wu J.Y., Xu X.E., Huang Q., Shen J., Chen H.B., Li E.M., Xu L.Y. Neutrophil gelatinase-associated lipocalin and its receptor: independent prognostic factors of oesophageal squamous cell carcinoma. J. Clin. Pathol. 2011, 64:69-74.
6. Fang W.K., Xu L.Y., Lu X.F., Liao L.D., Cai W.J., Shen Z.Y., Li E.M. A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells. Biochem. J. 2007, 403:297-303.
7. Friedl A., Stoesz S.P., Buckley P., Gould M.N. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression. Histochem. J. 1999, 31:433-441.
8. Goetz D.H., Holmes M.A., Borregaard N., Bluhm M.E., Raymond K.N., Strong R.K. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 2002, 10:1033-1043.
9. Hraba-Renevey S., Türler H., Kress M., Salomon C., Weil R. SV40-induced expression of mouse gene 24p3 involves a post-transcriptional mechanism. Oncogene 1989, 4:601-608.
10. Hu L., Hittelman W., Lu T., Ji P., Arlinghaus R., Shmulevich I., Hamilton S.R., Zhang W. NGAL decreases E-cadherin-mediated cell-cell adhesion and increases cell motility and invasion through Rac1 in colon carcinoma cells. Lab. Invest. 2009, 89:531-548.
11. Hvidberg V., Jacobsen C., Strong R.K., Cowland J.B., Moestrup S.K., Borregaard N. The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett. 2005, 579:773-777.
12. Kjeldsen L., Johnsen A.H., Sengeløv H., Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 1993, 268:10425-10432.
13. Kounnas M.Z., Loukinova E.B., Stefansson S., Harmony J.A.K., Brewer B.H., Strickland D.K., Argraves W.S. Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. J. Biol. Chem. 1995, 270:13070-13075.
14. Lax S.F. Molecular genetic pathways in various types of endometrial carcinoma: from a phenotypical to a molecular-based classification. Virchows Arch. 2004, 444:213-223.
15. Lee H.J., Lee E.K., Lee K.J., Hong S.W., Yoon Y., Kim J.S. Ectopic expression of neutrophil gelatinase-associated lipocalin suppresses the invasion and liver metastasis of colon cancer cells. Int. J. Cancer 2006, 118:2490-2497.
16. Lin H.H., Li W.W., Lee Y.C., Chu S.T. Apoptosis induced by uterine 24p3 protein in endometrial carcinoma cell line. Toxicology 2007, 234:203-215.
17. Lin H.H., Liao C.J., Lee Y.C., Hu K.H., Meng H.W., Chu S.T. Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration. Int. J. Biol. Sci. 2011, 7:74-86.
18. Liu M.F., Jin T., Shen J.H., Shen Z.Y., Zheng Z.C., Zhang Z.L., Xu L.Y., Li E.M., Xu H.X. NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis. J. Neurooncol. 2010, [Epub ahead of print].
19. Matsuda T., Marugame T., Kamo K.I., Katanoda K., Ajiki W., Sobue T. Cancer incidence and incidence rates in Japan in 2005: based on data from 12 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project. Jpn. J. Clin. Oncol. 2011, 41:139-147. The Japan Cancer Surveillance Research Group.
20. Miyamoto T., Kashima H., Suzuki A., Kikuchi N., Konishi I., Seki N., Shiozawa T. Laser captured microdissection-microarray analysis of the genes involved in endometrial carcinogenesis: stepwise up-regulation of lipocalin2 expression in normal and neoplastic endometria, and its functional relevance. Hum. Pathol. 2011, [Epub ahead of print].
21. Moestrup S.K., Cui S., Vorum H., Bregengard C., Bjorn S.E., Norris K., Gliemann J., Christensen E.I. Evidence that epithelial glycoprotein 330/megalin mediates uptake of polybasic drugs. J. Clin. Invest. 1995, 96:1404-1413.
22. Nagai M., Meerloo T., Takeda T., Farquhar M.G. The adaptor protein ARH escorts megalin to and through endosomes. Mol. Biol. Cell 2003, 14:4984-4996.
23. Nykjaer A., Dragun D., Walther D., Vorum H., Jacobsen C., Herz J., Melsen F., Christensen E.I., Willnow T.E. An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3. Cell 1999, 96:507-515.
24. Ronnett B.M., Zaino R.J., Ellenson L.H., Kurman R.J. Endometrial carcinoma. Blaunstein's Pathology of the Female Genital Tract 2002, 501-559. Springer-Verlag New York, Inc., New York. 5th ed. R.J. Kurman (Ed.).
25. Sheng Z., Wang S.Z., Green M.R. Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R. EMBO J. 2009, 28:866-876.
26. Shiozawa T., Horiuchi A., Kato K., Obinata M., Konishi I., Fujii S., Nikaido T. Up-regulation of p27Kip1 by progestins is involved in the growth suppression of the normal and malignant human endometrial glandular cells. Endocrinology 2001, 142:4182-4188.
27. Stoesz S.P., Friedl A., Haag J.D., Lindstrom M.J., Clark G.M., Gould M.N. Heterogeneous expression of the lipocalin NGAL in primary breast cancers. Int. J. Cancer 1998, 79:565-572.
28. Xu S.Y., Pauksen K., Venge P. Serum measurements of human neutrophil lipocalin (HNL) discriminate between acute bacterial and viral infections. Scand. J. Clin. Lab. Invest. 1995, 55:125-131.
29. Yan L., Borregaard N., Kjeldsen L., Moses M.A. The high molecular weight urinary matrix metalloproteinase (MMP) activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin (NGAL). Modulation of MMP-9 activity by NGAL. J. Biol. Chem. 2001, 276:37258-37265.
30. Yang J., Goetz D., Li J.Y., Wang W., Mori K., Setlik D., Du T., Erdjument-Bromage H., Tempst P., Strong R., Barasch J. An iron delivery pathway mediated by a lipocalin. Mol. Cell 2002, 10:1045-1056.
31. Yang J., Bielenberg D.R., Rodig S.J., Doiron R., Clifton M.C., Kung A.L., Strong R.K., Zurakowski D., Moses M.A. Lipocalin 2 promotes breast cancer progression. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:3913-3918.
32. Zhang H., Xu L., Xiao D., Xie J., Zeng H., Wang Z., Zhang X., Niu Y., Shen Z., Shen J., Wu X., Li E. Upregulation of neutrophil gelatinase-associated lipocalin in oesophageal squamous cell carcinoma: significant correlation with cell differentiation and tumour invasion. J. Clin. Pathol. 2007, 60:555-561.