Testicular germ cell tumours in dogs are predominantly of spermatocytic seminoma type and are frequently associated with somatic cell tumours

International Journal of Andrology

Volumn 34, Issue 4 PART 2, 2011, Pages

  Bush, J M ^a   Gardiner, D W ^a   Palmer, J S ^b   Rajpert De Meyts, E ^c   Veeramachaneni, D N R ^b  

^a IDEXX LABORATORIES   (United States)

^b Department of Environmental and Radiological Health Sciences   (United States)

^c University of Copenhagen   (Denmark)

Author keywords

Canine germ cell tumours; Classical seminoma; DAZ; DMRT1; Dog

Indexed keywords

DELETED IN AZOOSPERMIA FACTOR; DOUBLESEX AND MAB 3 RELATED TRANSCRIPTION FACTOR 1; PLAP PROTEIN; STEM CELL FACTOR RECEPTOR; TRANSCRIPTION FACTOR; TUMOR MARKER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOMA IN SITU; DOG; GERM CELL TUMOR; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEMINOMA; SOMATIC CELL TUMOR; SPERMATOCYTIC SEMINOMA;

ANIMALS; DOGS; EXTRACELLULAR MATRIX PROTEINS; HUMANS; MALE; NEOPLASMS, GERM CELL AND EMBRYONAL; PROTO-ONCOGENE PROTEINS C-KIT; RNA-BINDING PROTEINS; SEMINOMA; TESTICULAR NEOPLASMS; TRANSCRIPTION FACTORS;

EID: 79960874094     PISSN: 01056263     EISSN: 13652605     Source Type: Journal    
DOI: 10.1111/j.1365-2605.2011.01166.x     Document Type: Article

References (36)

1. Aubry F, Satie AP, Rioux-Leclercq N, Rajpert-De Meyts E, Spagnoli GC, Chomez P, De Backer O, Jégou B & Samson M. (2001) MAGE-A4, a germ cell specific marker, is expressed differentially in testicular tumors. Cancer 92, 2778-2785.
2. Eble JN. (1994) Spermatocytic seminoma. Hum Pathol 10, 1035-1042.
3. Goriely A & Wilkie AO. (2010) Missing heritability: paternal age effect mutations and selfish spermatogonia. Nat Rev Genet 11, 589-590.
4. Goriely A, Hansen RM, Taylor IB, Olesen IA, Jacobsen GK, McGowan SJ, Pfeifer SP, McVean GA, Meyts ER & Wilkie AO. (2009) Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors. Nat Genet 41, 1247-1252.
5. Grieco V, Rondena M, Romussi S, Stefanello D & Finazzi M. (2004) Immunohistochemical characterization of the leucocytic infiltrate associated with canine seminomas. J Comp Pathol 130, 278-284.
6. Grieco V, Riccardi E, Rondena M, Ciampi V & Finazzi M. (2007) Classical and spermatocytic seminoma in the dog: histochemical and immunohistochemical findings. J Comp Pathol 137, 41-46.
7. Grieco V, Riccardi E, Greppi GF, Teruzzi F, Iermanò V & Finazzi M. (2008) Canine testicular tumours: a study on 232 dogs. J Comp Pathol 138, 86-89.
8. Grieco V, Banco B, Giudice C, Mosca F & Finazzi M. (2010) Immunohistochemical expression of the KIT protein (CD117) in normal and neoplastic canine testes. J Comp Pathol 142, 213-217.
9. Hayes HM & Pendergrass TW. (1976) Canine testicular tumors: epidemiologic features of 410 dogs. Int J Cancer 18, 482-487.
10. Honecker F, Stoop H, de Krijger RR, Chris Lau YF, Bokemeyer C & Looijenga LH. (2004) Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells. J Pathol 203, 849-857.
11. Jacobsen GK & Talerman A. (1989). In: Atlas of Germ Cell Tumours. pp. 31-65. Munksgaard, Copenhagen.
12. Jørgensen N, Rajpert-De Meyts E, Graem N, Müller J, Giwercman A & Skakkebaek NE. (1995) Expression of immunohistochemical markers for testicular carcinoma in situ by normal human fetal germ cells. Lab Invest 72, 223-231.
13. Kennedy PC, Cullen JM, Edwards JF, Goldschmidt MH, Larsen S, Munson L & Nielsen S. (1998). In: Histological Classification of Tumors of the Genital System of Domestic Animals, (Second Series). Vol.4. pp. 17-18. Armed Forces Institute of Pathology, Washington, DC.
14. Looijenga LH, Olie RA, van der Gaag I, van Sluijs FJ, Matoska J, Ploem-Zaaijer J, Knepflé C & Oosterhuis JW. (1994) Seminomas of the canine testis. Counterpart of spermatocytic seminoma of men? Lab Invest 71, 490-496.
15. Looijenga LH, Hersmus R, Gillis AJ, Pfundt R, Stoop HJ, van Gurp RJ et al. (2006) Genomic and expression profiling of human spermatocytic seminomas: primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene. Cancer Res 66, 290-302.
16. Looijenga LH, Stoop H, Hersmus R, Gillis AJ & Oosterhuis JW. (2007) Genomic and expression profiling of human spermatocytic seminomas: pathogenetic implications. Int J Androl 30, 328-335.
17. Loveland K, Rajpert-De Meyts E & Veeramachaneni DNR. (2010) Testicular cancer. In: Comprehensive Toxicology, 2nd edn (ed. CA McQueen), pp. 247-263. Oxford Academic Press, London.
18. MacLachlan NJ & Kennedy PC. (2002) Tumors of the genital systems. In: Tumors in Domestic Animals. pp. 563-565. Iowa State Press, Ames, IA.
19. Maiolino P, Restucci B, Papparella S, Paciello O & De Vico G. (2004) Correlation of nuclear morphometric features with animal and human World Health Organization International Histological Classifications of canine spontaneous seminomas. Vet Pathol 41, 608-611.
20. Matson CK, Murphy MW, Griswold MD, Yoshida S, Bardwell VJ & Zarkower D. (2010) The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. Dev Cell 19, 612-624.
21. Müller J, Skakkebaek NE & Parkinson MC. (1987) The spermatocytic seminoma: views on pathogenesis. Int J Androl 10, 147-156.
22. Oosterhuis JW & Looijenga LHJ. (2005) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5, 210-222.
23. Rajpert-De Meyts E. (2006) Developmental model for the pathogenesis of testicular carcinoma in situ: genetic and environmental aspects. Hum Reprod Update 12, 303-323.
24. Rajpert-De Meyts E. (2007) Recent advances and future directions in research on testicular germ cell cancer. Int J Androl 30, 192-197.
25. Rajpert-De Meyts E, Kvist M & Skakkebaek NE. (1996) Heterogeneity of expression of immunohistochemical tumour markers in testicular carcinoma in situ: pathogenetic relevance. Virchows Arch 428, 133-139.
26. Rajpert-De Meyts E, Jacobsen GK, Bartkova J, Aubry F, Samson M, Bartek J & Skakkebaek NE. (2003) The immunohistochemical expression pattern of Chk2, p53, p19INK4d, MAGE-A4 and other selected antigens provides new evidence for the premeiotic origin of spermatocytic seminoma. Histopathology 42, 217-226.
27. Saegusa Y, Hayashi H, Taniai E, Imaoka M, Ohishi T, Wang L, Mitsumori K & Shibutani M. (2010). Spermatocytic seminoma with neuroectodermal differentiation and Sertoli cell tumor in a dog. Vet Pathol [Epub ahead of print].
28. Satie AP, Rajpert-De Meyts E, Spagnoli GC, Henno S, Olivo L, Jacobsen GK, Rioux-Leclercq N, Jégou B & Samson M. (2002) The cancer-testis gene, NY-ESO-1, is expressed in normal fetal and adult testes and in spermatocytic seminomas and testicular carcinoma in situ. Lab Invest 82, 775-780.
29. Skakkebaek NE, Berhelsen JG, Giwercman A & Muller J. (1987) Carcinoma-in-situ of the testis: possible origin from gonocytes and precursor of all types of germ cell tumours except spermatocytoma. Int J Androl 10, 19-28.
30. Sonne SB, Hoei-Hansen CE, Fisher JS, Leffers H, Rajpert-de Meyts E & Skakkebaek NE. (2004) Do environmental factors play a role in the aetiology of carcinoma in situ testis and the testicular dysgenesis syndrome? Verh Dtsch Ges Pathol 88, 144-151.
31. Sonne SB, Almstrup K, Dalgaard M, Juncker AS, Edsgard D, Ruban L et al. (2009) Analysis of gene expression profiles of microdissected cell populations indicates that testicular carcinoma in situ is an arrested gonocyte. Cancer Res 69, 5241-5250.
32. Ulbright TM, Amin MB & Young RH. (1999) Tumors of the testis, adnexa, spermatic cord and scrotum. In: Atlas of Tumor Pathology. Armed Forces Institute of Pathology, Bethesda, MD.
33. Veeramachaneni DNR & Sawyer HR. (1998) Carcinoma in situ and seminoma in equine testis. APMIS 106, 183-186.
34. Veeramachaneni DNR & Vandewoude S. (1999) Interstitial cell tumour and germ cell tumour with carcinoma in situ in rabbit testes. Int J Androl 22, 97-101.
35. Veeramachaneni DNR, Amann RP & Jacobson JP. (2006) Testis-antler dysgenesis in Sitka Black-tailed deer on Kodiak Island, Alaska: Sequela of environmental endocrine disruption? Environ Health Perspect 114(Suppl. 1), 51-59.
36. Yu CH, Hwang DN, Yhee JY, Kim JH, Im KS, Nho WG, Lyoo YS & Sur JH. (2009) Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors. J Vet Sci 10, 1-7.