Photolon™ - Photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes

International Journal of Oncology

Volumn 39, Issue 4, 2011, Pages 821-831

  Ali Seyed, Mohamed ^a,d   Bhuvaneswari, Ramaswamy ^a   Soo, Khee Chee ^a   Olivo, Malini ^a,b,c  

^a DIVISION OF MEDICAL ONCOLOGY   (Singapore)

^b NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d SRM INSTITUTE OF SCIENCE AND TECHNOLOGY   (India)

Author keywords

Apoptosis; Lysosomes; Mitochondria; Photolon ; Photosensitization

Indexed keywords

BETA ACTIN; CASPASE 3; CHLORIN E6 POLYVINYLPYRROLIDONE CONJUGATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PHOTOLON; PHOTOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CELL COMPARTMENTALIZATION; CELL DESTRUCTION; CELL NUCLEUS; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DRUG SELECTIVITY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CASPASE 3; CATHEPSIN D; CELL LINE; CELL LINE, TUMOR; HUMANS; HYDROGEN PEROXIDE; LYSOSOMES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PHOSPHATIDYLSERINES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POVIDONE; PROTOPORPHYRINS; REACTIVE OXYGEN SPECIES;

EID: 79960871008     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1109     Document Type: Article

References (53)

1. Dougherty TJ: Photodynamic therapy. Photochem Photobiol 58: 895-900, 1993.
2. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J and Peng Q: Photodynamic therapy. J Natl Cancer Inst 90: 889-905, 1998. (Pubitemid 28304157)
3. Reynolds T: Photodynamic therapy expands its horizons. J Natl Cancer Inst 89: 112-114, 1997.
4. Rowe PM: Photodynamic therapy begins to shine. Lancet 351: 1496, 1998.
5. Kostenich GA, Zhuravkin IN and Zhavrid EA: Experimental grounds for using chlorin e6 in the photodynamic therapy of malignant tumors. J Photochem Photobiol B 22: 211-217, 1994. (Pubitemid 24082920)
6. Lukyanov AN and Torchilin VP: Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv Drug Deliv Rev 56: 1273-1289, 2004. (Pubitemid 38510474)
7. Kaneda Y, Tsutsumi Y, Yoshioka Kamada H, Yamamoto X, Kodaira H, Tsunoda S, Okamoto T, Mukai Y, Shibata H, Nakagawa S and Mayumi T: The use of PVP as a polymeric carrier to improve the plasma half-life of drugs. Biomaterials 25: 3259-3266, 2004. (Pubitemid 38234786)
8. Isakau HA, Parkhats MV, Knyukshto VN, Dzhagarov BM, Petrov EP and Petrov PT: Toward understanding the high PDT efficacy of chlorin e6- polyvinylpyrrolidone formulations: photo-physical and molecular aspects of photosensitizer-polymer interaction in vitro. J Photochem Photobiol B 92: 165-174, 2008.
9. Shliakhtsin SV, Trukhachova TV, Isakau HA and Istomin YP: Pharmacokinetics and biodistribution of Photolon (Fotolon) in intact and tumor-bearing rats. Photodiagnosis Photodyn Ther 6: 97-104, 2009.
10. Calzavara-Pinton PG, Venturini M and Sala R: Photodynamic therapy: update 2006. Part 1: Photochemistry and photobiology. J Eur Acad Dermatol Venereol 21: 293-302, 2007.
11. Kessel D and Woodburn K: Bio-distribution of photosensitizing agents (Review). Int J Biochem 25: 1377-1383, 1993.
12. Luo Y and Kessel D: Initiation of apoptosis versus necrosis by photodynamic therapy with chloroaluminum phthalocyanine (Review). Photochem Photobiol 66: 479-483, 1997. (Pubitemid 127470193)
13. Chin WW, Heng PW, Thong PS, Bhuvaneswari R, Kuenzel HWS, Soo KS and Olivo M: Improved formulation of photosensitizer chlorin e6 polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur J Pharm Biopharm 69: 1083-1093, 2008.
14. Pervaiz S, Seyed MA, Hirpara JL, Clement MV and Loh KW: Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. Blood 93: 4096-4108, 1999. (Pubitemid 29279251)
15. Ali SM, Chee SK, Yuen GY and Olivo M: Hypocrellins and Hypericin induced apoptosis in human tumor cells: a possible role of hydrogen peroxide. Int J Mol Med 9: 461-472, 2002.
16. Nutku E, Hudson SA and Bochner BS: Mechanism of Siglec-8-induced human eosinophil apoptosis: role of caspases and mitochondrial injury. Biochem Biophys Res Commun 336: 918-924, 2005. (Pubitemid 41338356)
17. Ali SM and Olivo M: Bio-distribution and subcellular localization of hypericin and its role in PDT induces apoptosis in cancer cells. Int J Oncol 21: 531-540, 2002.
18. Possel H, Noack N, Augustin W, Keilhoff G and Wolf G: 2,7-Dihydrodichlorofluorescein diacetate as a fluorescent marker for peroxynitrite formation. FEBS Lett 416: 175-178, 1997. (Pubitemid 27462782)
19. Strømhaug PE, Berg TO, Fengsrud M and Seglen PO: Purification and characterization of autophagosomes from rat hepatocytes. Biochem J 335: 217-224, 1998. (Pubitemid 28491054)
20. Granville DJ, Carthy CM, Jiang H, Shore GC, McManus BM and Hunt DW: Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Lett 437: 5-10, 1998. (Pubitemid 28498230)
21. Leist and Jaattela M: Triggering of apoptosis by cathepsins. Cell Death Differ 8: 324-326, 2001.
22. Salvesen A: Lysosomal protease enters the death scene. J Clin Invest 107: 21-22, 2001.
23. Jaattela M, Cande C and Kroemer G: Lysosomes and mitochondria in the commitment to apoptosis: a potential role for cathepsin D and AIF. Cell Death Differ 11: 135-136, 2004. (Pubitemid 38159636)
24. Berg K and Moan J: Lysosomes and microtubules as targets for photochemotherapy of cancer. Photochem Photobiol 65: 403-409, 1997. (Pubitemid 27158971)
25. Noodt BB, Berg K, Stokke T, Peng Q and Nesland JM: Different apoptotic pathways are induced from various intracellular sites by tetraphenylporphyrins and light. Br J Cancer 79: 72-81, 1999. (Pubitemid 28566929)
26. Kennedy JC, Pottier RH and Pross DC: Photodynamic therapy with endogenous protoporphyrin IX: basic principles and present clinical experience. J Photochem Photobiol B 6: 143-148, 1990.
27. Ali SM and Olivo M: Nitric oxide mediated photo-induced cell death in human malignant cells. Int J Oncol 22: 751-756, 2003.
28. Morgan J and Oseroff AR: Mitochondria-based photodynamic anti-cancer therapy. Adv Drug Deliv Rev 49: 71-86, 2001. (Pubitemid 32493801)
29. Sakharov DV, Bunschoten A, van Weelden H and Wirtz KW: Photodynamic treatment and H2O2-induced oxidative stress result in different patterns of cellular protein oxidation. Eur J Biochem 270: 4859-4865, 2003. (Pubitemid 38021568)
30. Kessel D, Woodburn K, Gomer GJ, Jagerovic N and Smith KM: Photosensitization with derivatives of chlorin p6. J Photochem Photobiol B 28: 13-18, 1995.
31. Lee CC, Pouge BW, Strawbridge RR, Moodie KL, Bartholomew LR, Burke GC and Hoopes PJ: Comparison of photosensitizer (AIPcS2) quantification techniques: in situ fluorescence microsampling versus tissue chemical extraction. Photochem Photobiol 74: 453-460, 2001.
32. Gardner AM, Xu FH, Fady C, Jacoby FJ, Duffey DC, Tu Y and Lichtenstein A: Apoptotic vs. non-apoptotic cytotoxicity induced by hydrogen peroxide. Free Radic Biol Med 22: 73-83, 1997.
33. Yin L, Stearns R and González-Flecha B: Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells. J Cell Biochem 94: 433-445, 2005. (Pubitemid 41420282)
34. Lee Mason CW, Goodman CB, Holder MS, Kirksey OW, Womble TA, Severs WB and Palm DE: Hydrogen peroxide induces lysosomal protease alterations in PC12 cells. Neurochem Res 32: 1499-1510, 2007. (Pubitemid 47094412)
35. Valenzeno D: Photomodification of biological membranes with emphasis on singlet oxygen mechanisms. Photochem Photobiol 46: 146-160, 1987.
36. Nonell in S, Jori G, Pottier RH, Rodgers MAJ and Truscott TG (eds): Photobiology in Medicine. Plenum Press, New York, NY, p29, 1994.
37. Peng Q, Moan J and Nesland JM: Correlation of subcellular localization and intratumoral photosensitizer localization with ultrastructural features after photodynamic therapy. Ultrastruct Pathol 20: 109-129, 1996. (Pubitemid 26117614)
38. Thong PS, Ong KW, Goh NS, Kho KW, Manivasager V, Bhuvaneswari R, Olivo M and Soo KC: Photodynamic-therapy-activated immune response against distant untreated tumors in recurrent angiosarcoma. Lancet Oncol 8: 950-952, 2007. (Pubitemid 47488070)
39. Winters U, Daayana S, Lear JT, Tomlinson AE, Elkord E, Stern PL and Kitchener HC: Clinical and immunologic results of a phase II trial of sequential imiquimod and photodynamic therapy for vulval intraepithelial neoplasia. Clin Cancer Res 14: 5292-5299, 2008.
40. Oleinick NL, Morris RL and Belichenko I: The role of apoptosis in response to photodynamic therapy: what, where, why, and how. Photochem Photobiol Sci 1: 1-2, 2002.
41. Kowaltowski AJ, De Souza-Pinto NC, Castilho RF and Vercesi AE: Mitochondria and reactive oxygen species. Free Radic Biol Med 47: 333-343, 2009.
42. Kessel D and Luo Y: Photodynamic therapy: a mitochondrial inducer of apoptosis. Cell Death Differ 6: 28-35, 1999. (Pubitemid 29051852)
43. Lam M, Oleinick NL and Nieminen AL: Photodynamic therapy induced apoptosis in epidermoid carcinoma cells. Reactive oxygen species and mitochondrial inner membrane permeabilization. J Biol Chem 276: 47379-47386, 2001.
44. Pouge B, Ortel B, Chen N, Redmond R and Hasan T: A photo-biological and photophysical-based study of phototoxicity of two chlorines. Cancer Res 6: 717-724, 2001. (Pubitemid 32128638)
45. Gèze M, Morlière P, Mazière JC, Smith KM and Santus R: Lysosomes, a key of hydrophobic photosensitizers proposed for photochemotherapeutic applications. J Photochem Photobiol B 20: 23-35, 1993. (Pubitemid 23257591)
46. Kessel D, Luo Y, Mathieu P and Reiners JJ Jr: Determinants of the apoptotic response to lysosomal photodamage. Photochem Photobiol 71: 196-200, 2000.
47. Reiners JJ Jr, Caruso JA, Mathieu P, Chelladurai B, Yin XM and Kessel D: Release of cytochrome c and activation of pro-caspase-9 following lysosomal photodamage involves Bid cleavage. Cell Death Differ 9: 934-944, 2002. (Pubitemid 35033432)
48. Blomgran R, Zheng L and Stendahl O: Cathepsin-cleaved Bid promotes apoptosis in human neutrophils via oxidative stress-induced lysosomal membrane permeabilization. J Leukoc Biol 81: 1213-1223, 2007. (Pubitemid 46702040)
49. Godar DE: Light and death: photons and apoptosis. J Invest Dermatol 4: 17-23, 1999.
50. Li R, Bounds DJ, Granville D, Ip SH, Jiang H, Margaron P and Hunt DW: Rapid induction of apoptosis in human keratinocytes with the photosensitizer QLT0074 via a direct mitochondrial action. Apoptosis 8: 269-275, 2003. (Pubitemid 36749612)
51. Roberts WG and Berns MW: In vitro photosensitization I. Cellular uptake and subcellular localization of mono-L-aspartyl chlorin e6, chloro-aluminum sulfonated phthalocyanine, and photofrin II. Lasers Surg Med 9: 90-101, 1989. (Pubitemid 19119397)
52. Alper T: Cellular Radiobiology. Cambridge University Press, Cambridge, 1979.
53. Yano T, Takahashi S and Ichikawa T: Active oxygen generated in the process of carcinogen metabolism can induce oxidative damage in nuclei. Res Commun Mol Pathol Pharmacol 87: 367-370, 1995.