Tumor-produced, active Interleukin-1 β regulates gene expression in carcinoma-associated fibroblasts

Experimental Cell Research

Volumn 317, Issue 15, 2011, Pages 2222-2229

  Dudás, József ^a   Fullár, Alexandra ^a,b   Bitsche, Mario ^a   Schartinger, Volker ^a   Kovalszky, Ilona ^b   Sprinzl, Georg Mathias ^a   Riechelmann, Herbert ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Carcinoma associated fibroblasts (CAFs); Interferon regulatory factor 1 (IRF1); Interleukin 1 receptor associated kinase 1 (IRAK 1); Interleukin 6 (IL 6); Nuclear factor kappa beta (NF B ); Prostaglandin endoperoxide synthase 2 (COX 2)

Indexed keywords

CYCLOOXYGENASE 2; DEXAMETHASONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6;

ARTICLE; CARCINOMA ASSOCIATED FIBROBLAST; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOUTH CARCINOMA; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TUMOR CELL; WESTERN BLOTTING;

EID: 79960844181     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.05.023     Document Type: Article

References (35)

1. Orimo A., Weinberg R.A. Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle 2006, 5:1597-1601.
2. Mishra P.J., Mishra P.J., Humeniuk R., Medina D.J., Alexe G., Mesirov J.P., Ganesan S., Glod J.W., Banerjee D. Carcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells. Cancer Res. 2008, 68:4331-4339.
3. Dudas J., Bitsche M., Schartinger V., Falkeis C., Sprinzl G.M., Riechelmann H. Fibroblasts produce brain-derived neurotrophic factor and induce mesenchymal transition of oral tumor cells. Oral Oncol. 2011, 47(2):98-103.
4. Daly A.J., McIlreavey L., Irwin C.R. Regulation of HGF and SDF-1 expression by oral fibroblasts-implications for invasion of oral cancer. Oral Oncol. 2008, 44:646-651.
5. Higashikawa K., Yoneda S., Taki M., Shigeishi H., Ono S., Tobiume K., Kamata N. Gene expression profiling to identify genes associated with high-invasiveness in human squamous cell carcinoma with epithelial-to-mesenchymal transition. Cancer Lett. 2008, 264:256-264.
6. Paterlini-Brechot P., Benali N.L. Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett. 2007, 253:180-204.
7. Kennedy A.L., McBryan T., Enders G.H., Johnson F.B., Zhang R., Adams P.D. Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci. Cell Div. 2010, 5:16.
8. Hoot K.E., Lighthall J., Han G., Lu S.L., Li A., Ju W., Kulesz-Martin M., Bottinger E., Wang X.J. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J. Clin. Invest. 2008, 118:2722-2732.
9. Casarsa C., Bassani N., Ambrogi F., Zabucchi G., Boracchi P., Biganzoli E., Coradini D. Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma. Cancer Lett. 2011, 302:136-143.
10. Kupferman M.E., Jiffar T., El Naggar A., Yilmaz T., Zhou G., Xie T., Feng L., Wang J., Holsinger F.C., Yu D., Myers J.N. TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene 2010, 29:2047-2059.
11. Saha R.N., Liu X., Pahan K. Up-regulation of BDNF in astrocytes by TNF-alpha: a case for the neuroprotective role of cytokine. J. Neuroimmune Pharmacol. 2006, 1:212-222.
12. Yan C., Grimm W.A., Garner W.L., Qin L., Travis T., Tan N., Han Y.P. Epithelial to mesenchymal transition in human skin wound healing is induced by tumor necrosis factor-alpha through bone morphogenic protein-2. Am. J. Pathol. 2010, 176:2247-2258.
13. Yamauchi Y., Kohyama T., Takizawa H., Kamitani S., Desaki M., Takami K., Kawasaki S., Kato J., Nagase T. Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1. Exp. Lung Res. 2010, 36:12-24.
14. Auron P.E., Webb A.C., Rosenwasser L.J., Mucci S.F., Rich A., Wolff S.M., Dinarello C.A. Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc. Natl. Acad. Sci. U.S.A. 1984, 81:7907-7911.
15. Miyazawa K., Mori A., Okudaira H. Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by glucocorticoids. J. Biochem. 1998, 124:1130-1137.
16. Yang C.M., Luo S.F., Hsieh H.L., Chi P.L., Lin C.C., Wu C.C., Hsiao L.D. Interleukin-1beta induces ICAM-1 expression enhancing leukocyte adhesion in human rheumatoid arthritis synovial fibroblasts: involvement of ERK, JNK, AP-1, and NF-kappaB. J. Cell. Physiol. 2010, 224:516-526.
17. Dudas J., Mansuroglu T., Moriconi F., Haller F., Wilting J., Lorf T., Fuzesi L., Ramadori G. Altered regulation of Prox1-gene-expression in liver tumors. BMC Cancer 2008, 8:92.
18. Haller F., Kulle B., Schwager S., Gunawan B., von Heydebreck A., Sultmann H., Fuzesi L. Equivalence test in quantitative reverse transcription polymerase chain reaction: confirmation of reference genes suitable for normalization. Anal. Biochem. 2004, 335:1-9.
19. Moriconi F., Raddatz D., Ho N.A., Yeruva S., Dudas J., Ramadori G. Quantitative gene expression of cytokines in peripheral blood leukocytes stimulated in vitro: modulation by the anti-tumor nerosis factor-alpha antibody infliximab and comparison with the mucosal cytokine expression in patients with ulcerative colitis. Transl. Res. 2007, 150:223-232.
20. Zheng L., Yu C., Zhang Z., Yang C., Cai X. Expression of interferon regulatory factor 1, 3, and 7 in primary Sjogren syndrome. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2009, 107:661-668.
21. Witzel I.D., Milde-Langosch K., Wirtz R.M., Roth C., Ihnen M., Mahner S., Zu E.C., Janicke F., Muller V. Comparison of microarray-based RNA expression with ELISA-based protein determination of HER2, uPA and PAI-1 in tumour tissue of patients with breast cancer and relation to outcome. J. Cancer Res. Clin. Oncol. 2010, 136:1709-1718.
22. El Mansouri F.E., Chabane N., Zayed N., Kapoor M., Benderdour M., Martel-Pelletier J., Pelletier J.P., Duval N., Fahmi H. Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes. Arthritis Rheum. 2011, 63:168-179.
23. Dudas J., Ramadori G., Knittel T., Neubauer K., Raddatz D., Egedy K., Kovalszky I. Effect of heparin and liver heparan sulphate on interaction of HepG2-derived transcription factors and their cis-acting elements: altered potential of hepatocellular carcinoma heparan sulphate. Biochem. J. 2000, 350(Pt 1):245-251.
24. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
25. Loercher A., Lee T.L., Ricker J.L., Howard A., Geoghegen J., Chen Z., Sunwoo J.B., Sitcheran R., Chuang E.Y., Mitchell J.B., Baldwin A.S., Van W.C. Nuclear factor-kappaB is an important modulator of the altered gene expression profile and malignant phenotype in squamous cell carcinoma. Cancer Res. 2004, 64:6511-6523.
26. St John M.A., Dohadwala M., Luo J., Wang G., Lee G., Shih H., Heinrich E., Krysan K., Walser T., Hazra S., Zhu L., Lai C., Abemayor E., Fishbein M., Elashoff D.A., Sharma S., Dubinett S.M. Proinflammatory mediators upregulate snail in head and neck squamous cell carcinoma. Clin. Cancer Res. 2009, 15:6018-6027.
27. Kanazawa T., Nishino H., Hasegawa M., Ohta Y., Iino Y., Ichimura K., Noda Y. Interleukin-6 directly influences proliferation and invasion potential of head and neck cancer cells. Eur. Arch. Otorhinolaryngol. 2007, 264:815-821.
28. Malhotra R., Patel V., Vaque J.P., Gutkind J.S., Rusling J.F. Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification. Anal. Chem. 2010, 82:3118-3123.
29. Meyer F., Samson E., Douville P., Duchesne T., Liu G., Bairati I. Serum prognostic markers in head and neck cancer. Clin. Cancer Res. 2010, 16:1008-1015.
30. Duffy S.A., Taylor J.M., Terrell J.E., Islam M., Li Y., Fowler K.E., Wolf G.T., Teknos T.N. Interleukin-6 predicts recurrence and survival among head and neck cancer patients. Cancer 2008, 113:750-757.
31. Richey L.M., George J.R., Couch M.E., Kanapkey B.K., Yin X., Cannon T., Stewart P.W., Weissler M.C., Shores C.G. Defining cancer cachexia in head and neck squamous cell carcinoma. Clin. Cancer Res. 2007, 13:6561-6567.
32. Molotkov A., Satoh M., Tohyama C. Tumor growth and food intake in interleukin-6 gene knock-out mice. Cancer Lett. 1998, 132:187-192.
33. Abrahao A.C., Castilho R.M., Squarize C.H., Molinolo A.A., dos Santos-Pinto D., Gutkind J.S. A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation. Oral Oncol. 2010, 46:880-887.
34. Gallo O., Masini E., Bianchi B., Bruschini L., Paglierani M., Franchi A. Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. Hum. Pathol. 2002, 33:708-714.
35. Smith C.W., Chen Z., Dong G., Loukinova E., Pegram M.Y., Nicholas-Figueroa L., Van W.C. The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1alpha, IL-6, GM-CSF, and KC. Clin. Exp. Metastasis 1998, 16:655-664.