D,L-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (DL-PDMP) increases endoplasmic reticulum stress, autophagy and apoptosis accompanying ceramide accumulation via ceramide synthase 5 protein expression in A549 cells

Biochimie

Volumn 93, Issue 9, 2011, Pages 1446-1459

  Yamane, Mototeru ^a   Miyazawa, Keisuke ^a   Moriya, Shota ^a   Abe, Akihisa ^a   Yamane, Sayoko ^b  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autophagy; Ceramide synthase; CHOP; DL PDMP; LASS5

Indexed keywords

CAAT ENHANCER BINDING PROTEIN HOMOLOGOUS PROTEIN; CASPASE 3; CERAMIDE; CERAMIDE SYNTHASE 5 PROTEIN; CYTOCHROME P450; DEXTRO,LEVO THREO 1 PHENYL 2 DECANOYLAMINO 3 MORPHOLINO 1 PROPANOL; HEXOSYLTRANSFERASE INHIBITOR; LACTATE DEHYDROGENASE; LONGEVITY ASSURANCE HOMOLOGUE 5 PROTEIN; MICROTUBULEV ASSOCIATED PROTEIN 1 LIGHT CHAIN 3B II PROTEIN; PEPTIDES AND PROTEINS; PROTEIN P62; REACTIVE OXYGEN METABOLITE; SYNTHETASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL MEMBRANE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MORPHOLOGY; PROTEIN BINDING; PROTEIN EXPRESSION;

APOPTOSIS; AUTOPHAGY; CELL LINE, TUMOR; CERAMIDES; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; HUMANS; MORPHOLINES; OXIDATIVE STRESS; SPHINGOSINE N-ACYLTRANSFERASE; TRANSCRIPTION FACTOR CHOP;

EID: 79960839036     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.04.016     Document Type: Article

References (34)

1. Y.A. Hannun The sphingomyelin cycle and the second messenger function of ceramide J. Biol. Chem. 269 1994 3125 3128 (Pubitemid 24237615)
2. S. Jayadev, B. Liu, A.E. Bielawska, J.Y. Lee, F. Nazaire, M.Y. Pushkareva, L.M. Obeid, and Y.A. Hannun Role for ceramide in cell cycle arrest J. Biol. Chem. 270 1995 2047 2052
3. K. Yokoyama, H. Nojiri, M. Suzuki, M. Setaka, A. Suzuki, and S. Nojima Clear differences in ceramide metabolism between glycosphingolipids and sphingomyelin in a human promyelocytic leukemia cell line HL-60 stimulated by a differentiation inducer FEBS Lett. 368 1995 477 480
4. L. Riboni, A. Prinetti, R. Bassi, A. Caminiti, and G. Tettamanti A mediator role of ceramide in the regulation of neuroblastoma neuro2a cell differentiation J. Biol. Chem. 270 1995 26868 26875
5. M.E. Venable, J.Y. Lee, M.J. Smyth, A. Bielawska, and L.M. Obeid Role of ceramide in cellular senescence J. Biol. Chem. 270 1995 30701 30708 (Pubitemid 26005136)
6. L.A. Pena, Z. Fuks, and R. Kolesnick Stress-induced apoptosis and the sphingomyelin pathway Biochem. Pharmacol. 53 1997 615 621 (Pubitemid 27148237)
7. F. Scarlatti, C. Bauvy, A. Ventruti, G. Sala, F. Cluzeaud, A. Vandewalle, R. Ghidoni, and P. Codogno Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1 J.Biol. Chem. 279 2004 18384 18391 (Pubitemid 38623254)
8. S. Pattingre, C. Bauvy, T. Levade, B. Levine, and P. Codogno Ceramide-induced autophagy: to junk or to protect cells? Autophagy 5 2009 558 560
9. E. Bieberich, B. Freischutz, M. Suzuki, and R.K. Yu Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells J. Neurochem. 72 1999 1040 1049 (Pubitemid 29085018)
10. T. Ravid, A. Tsaba, P. Gee, R. Rasooly, E.A. Medina, and T. Goldkorn Ceramide accumulation precedes caspase-3 activation during apoptosis of A549 human lung adenocarcinoma cells Am. J. Physiol. Lung Cell Mol. Physiol. 284 2003 L1082 L1092
11. M. Yamane, and S. Yamane The induction of colonocyte differentiation in CaCo-2 cells by sodium butyrate causes an increase in glucosylceramide synthesis in order to avoid apoptosis based on ceramide Arch. Biochem. Biophys. 459 2007 159 168 (Pubitemid 46367853)
12. S. Pattingre, C. Bauvy, S. Carpentier, T. Levade, B. Levine, and P. Codogno Role of JNK1-dependent Bcl-2 p.osphorylation in ceramide-induced macroautophagy J. Biol. Chem. 284 2009 2719 2728
13. J. Wei, M. Fujita, M. Nakai, M. Waragai, A. Sekigawa, S. Sugama, T. Takenouchi, E. Masliah, and M. Hashimoto Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies Am. J. Pathol. 174 2009 1891 1909
14. M. Yamane, and A. Abe Omega-hydroxylation activity toward leukotriene B(4) and polyunsaturated fatty acids in the human hepatoblastoma cell line, HepG2, and human lung adenocarcinoma cell line, A549 J. Biochem. 128 2000 827 835
15. T. Kurita-Ochiai, S. Amano, K. Fukushima, and K. Ochiai Cellular events involved in butyric acid-induced T cell apoptosis J. Immun. 171 2003 3576 3584 (Pubitemid 37254560)
16. B.F. Howell, S. McCune, and R. Schaffer Lactate-to-pyruvate or pyruvate-to-lactate assay for lactate dehydrogenase: a re-examination Clin. Chem. 25 1979 269 272 (Pubitemid 9142907)
17. J. Yu, S.A. Novgorodov, D. Chudakova, H. Zhu, A. Bielawska, J. Bielawski, L.M. Obeid, M.S. Kindy, and T.I. Gudz JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction J. Biol. Chem. 282 2007 25940 25949 (Pubitemid 47372813)
18. W. Seefelder, G. Schwerdt, R. Freudinger, M. Gekle, and H.-U. Humpf Liquid chromatography/electrospray ionisation-mass spectrometry method for the quantification of sphingosine and sphinganine in cell cultures exposed to fumonisins J. Chromatogr. B. 780 2002 137 144 (Pubitemid 35279752)
19. M. Yamane Simultaneous quantitative determination method for ceramide species from crude cellular extracts by high-performance liquid chromatography-thermospray mass spectrometry J. Chromatogr. B. 783 2003 181 190 (Pubitemid 35351644)
20. M. Yamane HPLC and LC-MS of sphingolipids J.-T. (Ken) Lin, T.A. Mckeon, HPLC of Acyl Lipids 2005 HNB Publishing Inc. New York 445 471
21. A. Ogura, Y. Watanabe, D. Iizuka, H. Yasui, M. Amitani, S. Kobayashi, M. Kuwabara, and O. Inanami Radiation-induced apoptosis of tumor cells is facilitated by inhibition of the interaction between Survivin and Smac/DIABLO Cancer Lett. 259 2008 71 81 (Pubitemid 350235093)
22. J. Coward, G. Ambrosini, E. Musi, J.-P. Truman, A. Haimovitz-Friedman, J.C. Allegood, E. Wang, A.H. Merrill Jr., and G.K. Schwartz Safingol (L-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway Autophagy 5 2009 184 193
23. J.E. Vance Phospholipid synthesis in a membrane fraction associated with mitochondria J. Biol. Chem. 265 1990 7248 7256
24. Y. Mizutani, A. Kihara, and Y. Igarashi Mammalian Lass6 and its related family members regulate synthesis of specific ceramides Biochem. J. 390 2005 263 271 (Pubitemid 41192252)
25. T. Verfaillie, M. Salazar, G. Velasco, and P. Agostinis Linking ER stress to autophagy: potential implications for cancer therapy Int. J. Cell Biol. 2010 2010 1 19
26. S.D. Spassieva, T.D. Mullen, D.M. Townsend, and L.M. Obei Disruption of ceramide synthesis by CerS2 down-regulation leads to autophagy and the unfolded protein response Biochem. J. 424 2009 273 283
27. P. Sridevi, H. Alexander, E.L. Laviad, Y. Pewzner-Jung, M. Hannink, A.H. Futerman, and S. Alexander Ceramide synthase 1 is regulated by proteasomal mediated turnover Biochim. Biophys. Acta 1793 2009 1218 1227
28. 2-induced injury through the PDK1/Akt pathway Neurosci. Lett. 450 2009 45 50
29. Z. Wang, X. Tang, Y. Li, C. Leu, L. Guo, X. Zheng, and D. Zhu 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells Eur. J. Pharmacol. 588 2008 9 17
30. M. Yamane, S. Shimizu, A. Abe, and S. Yamane Docosahexaenoic/arachidonic acid omega-hydroxylation system and differentiation in the human colonic adenocarcinoma cell line, Caco-2 Cancer Lett. 122 1998 51 59 (Pubitemid 28058617)
31. J. Stiban, L. Caputo, and M. Colombini Ceramide synthesis in the endoplasmic reticulum can permeabilize mitochondria to proapoptotic proteins J. Lipid Res. 49 2008 625 634
32. D. Ardail, I. Popa, K. Alcantara, A. Pons, J.P. Zanetta, P. Louisot, L. Thomas, and J. Portoukalian Occurrence of ceramides and neutral glycolipids with unusual long-chain base composition in purified rat liver mitochondria FEBS. Lett. 488 2001 160 164 (Pubitemid 32103589)
33. L.J. Siskind Mitochondrial ceramide and the induction of apoptosis J. Bioenerg. Biomembr. 37 2005 143 153 (Pubitemid 41420469)
34. D. Ardail, I. Popa, J. Bodennec, P. Louisot, D. Schmitt, and J. Portoukalian The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases Biochem. J. 371 2003 1013 1019 (Pubitemid 36578901)