메뉴 건너뛰기




Volumn 49, Issue 9, 2011, Pages 2243-2251

Safety evaluation of steroidal saponin DT-13 isolated from the tuber of Liriope muscari (Decne.) Baily

Author keywords

Acute oral toxicity; Ames test; Micronucleus test; Safety evaluation; Steroidal saponin DT 13; Subchronic toxicity

Indexed keywords

HISTIDINE; PLANT EXTRACT; STEROIDAL SAPONIN DT 13; UNCLASSIFIED DRUG;

EID: 79960836130     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.022     Document Type: Article
Times cited : (27)

References (44)
  • 1
    • 0016685233 scopus 로고
    • Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test
    • Ames B.N., McCann J., Yamasaki E. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 1975, 31:347-364.
    • (1975) Mutat. Res. , vol.31 , pp. 347-364
    • Ames, B.N.1    McCann, J.2    Yamasaki, E.3
  • 2
    • 13344283430 scopus 로고    scopus 로고
    • Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes
    • Amara-Mokrane Y.A., Lehucher-Michel M.P., Balansard G., Duménil G., Botta A. Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. Mutagenesis 1996, 11:161-167.
    • (1996) Mutagenesis , vol.11 , pp. 161-167
    • Amara-Mokrane, Y.A.1    Lehucher-Michel, M.P.2    Balansard, G.3    Duménil, G.4    Botta, A.5
  • 3
    • 53249086413 scopus 로고    scopus 로고
    • Gender differences in pharmacological response
    • Anderson G.D. Gender differences in pharmacological response. Int. Rev. Neurobiol. 2008, 83:1-10.
    • (2008) Int. Rev. Neurobiol. , vol.83 , pp. 1-10
    • Anderson, G.D.1
  • 7
    • 0025115784 scopus 로고
    • Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L
    • Elias R., Demeo M., Vidalollivier E., Laget M., Balansard G., Dumenil G. Antimutagenic activity of some saponins isolated from Calendula officinalis L., C. arvensis L. and Hedera helix L. Mutagenesis 1990, 5:327-331.
    • (1990) Mutagenesis , vol.5 , pp. 327-331
    • Elias, R.1    Demeo, M.2    Vidalollivier, E.3    Laget, M.4    Balansard, G.5    Dumenil, G.6
  • 8
    • 0025046279 scopus 로고
    • Application of pyrolysis-high-resolution gas chromatography-pattern recognition to the identification of the Chinese traditional medicine mai dong
    • Fang X.C., Yu B.Y., Xing B.R., An D.K. Application of pyrolysis-high-resolution gas chromatography-pattern recognition to the identification of the Chinese traditional medicine mai dong. J. Chromatogr. A 1990, 514:287-292.
    • (1990) J. Chromatogr. A , vol.514 , pp. 287-292
    • Fang, X.C.1    Yu, B.Y.2    Xing, B.R.3    An, D.K.4
  • 9
  • 11
  • 12
    • 0025203206 scopus 로고
    • The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides
    • Hayashi M., Morita T., Komada Y., Sofuni T., Ishidate M. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 1990, 245:245-249.
    • (1990) Mutat. Res. , vol.245 , pp. 245-249
    • Hayashi, M.1    Morita, T.2    Komada, Y.3    Sofuni, T.4    Ishidate, M.5
  • 13
    • 78651479375 scopus 로고    scopus 로고
    • Determination of 25 (R, S) ruscogenin 1-O-[β-d-glucopyranosyl (1→2)][β-d-xylopyranosyl (1→3)] β-d-fucopyranoside in Liriope muscari from different habitats and different harvest time by HPLC-ELSD
    • Hu Z.F., Jiang C., Qin M.J., Qi J., Yu B.Y. Determination of 25 (R, S) ruscogenin 1-O-[β-d-glucopyranosyl (1→2)][β-d-xylopyranosyl (1→3)] β-d-fucopyranoside in Liriope muscari from different habitats and different harvest time by HPLC-ELSD. China J. Chin. Mater. Med. 2010, 35:2508-2510.
    • (2010) China J. Chin. Mater. Med. , vol.35 , pp. 2508-2510
    • Hu, Z.F.1    Jiang, C.2    Qin, M.J.3    Qi, J.4    Yu, B.Y.5
  • 14
    • 34547842128 scopus 로고    scopus 로고
    • Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in Sprague-Dawley rats
    • Joshua Allan J., Damodaran A., Deshmukh N.S., Goudar K.S., Amit A. Safety evaluation of a standardized phytochemical composition extracted from Bacopa monnieri in Sprague-Dawley rats. Food Chem. Toxicol. 2007, 45:1928-1937.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1928-1937
    • Joshua Allan, J.1    Damodaran, A.2    Deshmukh, N.S.3    Goudar, K.S.4    Amit, A.5
  • 16
    • 0028290023 scopus 로고
    • Three-month oral repeated administration toxicity study of seed saponins of Thea sinensis L. (Ryokucha saponin) in rats
    • Kawaguchi M., Kato T., Kamada S., Yahata A. Three-month oral repeated administration toxicity study of seed saponins of Thea sinensis L. (Ryokucha saponin) in rats. Food Chem. Toxicol. 1994, 32:431-442.
    • (1994) Food Chem. Toxicol. , vol.32 , pp. 431-442
    • Kawaguchi, M.1    Kato, T.2    Kamada, S.3    Yahata, A.4
  • 17
    • 77951908366 scopus 로고    scopus 로고
    • Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells
    • Li F., Fernandez P.P., Rajendran P., Hui K.M., Sethi G. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010, 292:197-207.
    • (2010) Cancer Lett. , vol.292 , pp. 197-207
    • Li, F.1    Fernandez, P.P.2    Rajendran, P.3    Hui, K.M.4    Sethi, G.5
  • 18
    • 0035990593 scopus 로고    scopus 로고
    • Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix
    • Liu J.L., Chen T., Yu B.Y., Xu Q. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari inhibits lymphocyte adhesion to extracellular matrix. J. Pharm. Pharmacol. 2002, 54:959-966.
    • (2002) J. Pharm. Pharmacol. , vol.54 , pp. 959-966
    • Liu, J.L.1    Chen, T.2    Yu, B.Y.3    Xu, Q.4
  • 19
    • 0021048099 scopus 로고
    • A new approach to practical acute toxicity
    • Lorke D. A new approach to practical acute toxicity. Toxicology 1983, 54:275-287.
    • (1983) Toxicology , vol.54 , pp. 275-287
    • Lorke, D.1
  • 20
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
    • (1983) Mutat. Res. , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 23
    • 79960843358 scopus 로고    scopus 로고
    • OECD, 2001. OECD Guideline for Testing of Chemicals No. 423. Acute Oral Toxicity - Acute Toxic Class Method, adopted December 2001.
    • OECD, 2001. OECD Guideline for Testing of Chemicals No. 423. Acute Oral Toxicity - Acute Toxic Class Method, adopted December 2001.
  • 24
    • 79960836239 scopus 로고    scopus 로고
    • OECD, 1997. OECD Guideline for Testing of Chemicals No. 474. Mammalian Erythrocyte Micronucleus Test, adopted July 1997.
    • OECD, 1997. OECD Guideline for Testing of Chemicals No. 474. Mammalian Erythrocyte Micronucleus Test, adopted July 1997.
  • 25
    • 77953269709 scopus 로고    scopus 로고
    • Antitumor activities of dammarane triterpene saponins from Bacopa monniera
    • Peng L., Zhou Y., Kong de Y., Zhang W.D. Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother. Res. 2010, 24:864-868.
    • (2010) Phytother. Res. , vol.24 , pp. 864-868
    • Peng, L.1    Zhou, Y.2    Kong de, Y.3    Zhang, W.D.4
  • 26
    • 0023064090 scopus 로고
    • The chemistry and biological significance of saponins in foods and feedstuffs
    • Price K.R., Johnson I.T., Fenwick G.R. The chemistry and biological significance of saponins in foods and feedstuffs. Crit. Rev. Food Sci. Nutr. 1987, 26:27-135.
    • (1987) Crit. Rev. Food Sci. Nutr. , vol.26 , pp. 27-135
    • Price, K.R.1    Johnson, I.T.2    Fenwick, G.R.3
  • 27
    • 70450222919 scopus 로고    scopus 로고
    • Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H. Wright in rodents
    • Qin Y., Wu X., Huang W., Gong G., Li D., He Y., Zhao Y. Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H. Wright in rodents. J. Ethnopharmacol. 2009, 126:543-550.
    • (2009) J. Ethnopharmacol. , vol.126 , pp. 543-550
    • Qin, Y.1    Wu, X.2    Huang, W.3    Gong, G.4    Li, D.5    He, Y.6    Zhao, Y.7
  • 28
    • 0032420224 scopus 로고    scopus 로고
    • Different effects of newly isolated saponins on the mutagenicity and cytotoxicity of the anticancer drugs mitomycin C and bleomycin in human lymphocytes
    • Scarpato R., Bertoli A., Naccarati A., Migliore L., Cocchi L., Barale R., Pistelli L. Different effects of newly isolated saponins on the mutagenicity and cytotoxicity of the anticancer drugs mitomycin C and bleomycin in human lymphocytes. Mutat. Res. 1998, 420:49-54.
    • (1998) Mutat. Res. , vol.420 , pp. 49-54
    • Scarpato, R.1    Bertoli, A.2    Naccarati, A.3    Migliore, L.4    Cocchi, L.5    Barale, R.6    Pistelli, L.7
  • 29
    • 4344587843 scopus 로고    scopus 로고
    • Biological activities and distribution of plant saponins
    • Sparg S.G., Light M.E., van Staden J. Biological activities and distribution of plant saponins. J. Ethnopharmacol. 2004, 94:219-243.
    • (2004) J. Ethnopharmacol. , vol.94 , pp. 219-243
    • Sparg, S.G.1    Light, M.E.2    van Staden, J.3
  • 30
    • 79955027587 scopus 로고    scopus 로고
    • Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospa® Cough Tablets) in the treatment of colds accompanied by coughing
    • Stauss-Grabo M., Atiye S., Warnke A., Wedemeyer R.S., Donath F., Blume H.H. Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospa® Cough Tablets) in the treatment of colds accompanied by coughing. Phytomedicine 2011, 18:433-436.
    • (2011) Phytomedicine , vol.18 , pp. 433-436
    • Stauss-Grabo, M.1    Atiye, S.2    Warnke, A.3    Wedemeyer, R.S.4    Donath, F.5    Blume, H.H.6
  • 31
    • 77954473120 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue facto
    • Sun L., Lin S.S., Zhao R.P., Yu B.Y., Yuan S.T., Zhang L.Y. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces human breast cancer cell adhesion and migration during hypoxia via regulation of tissue facto. Biol. Pharm. Bull. 2010, 33:1192-1198.
    • (2010) Biol. Pharm. Bull. , vol.33 , pp. 1192-1198
    • Sun, L.1    Lin, S.S.2    Zhao, R.P.3    Yu, B.Y.4    Yuan, S.T.5    Zhang, L.Y.6
  • 32
    • 77954662168 scopus 로고    scopus 로고
    • Effect and mechanism of AR-6 in experimental rheumatoid arthritis
    • Sun S.X., Li Y.M., Fang W.R., Cheng P., Liu L., Li F. Effect and mechanism of AR-6 in experimental rheumatoid arthritis. Clin. Exp. Med. 2010, 10:113-121.
    • (2010) Clin. Exp. Med. , vol.10 , pp. 113-121
    • Sun, S.X.1    Li, Y.M.2    Fang, W.R.3    Cheng, P.4    Liu, L.5    Li, F.6
  • 33
    • 26444531635 scopus 로고    scopus 로고
    • The saponin monomer of dwarf lilyturf tuber, DT-13, reduces L-type calcium currents during hypoxia in adult rat ventricular myocytes
    • Tao J., Wang H.Y., Zhou H., Li S.N. The saponin monomer of dwarf lilyturf tuber, DT-13, reduces L-type calcium currents during hypoxia in adult rat ventricular myocytes. Life Sci. 2005, 77:3021-3030.
    • (2005) Life Sci. , vol.77 , pp. 3021-3030
    • Tao, J.1    Wang, H.Y.2    Zhou, H.3    Li, S.N.4
  • 34
    • 79956043638 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aqueous extract from Radix Liriope muscari and its major active fraction and component
    • Tian Y.Q., Kou J.P., Li L.Z., Yu B.Y. Anti-inflammatory effects of aqueous extract from Radix Liriope muscari and its major active fraction and component. Chin. J. Nat. Med. 2011, 9:222-226.
    • (2011) Chin. J. Nat. Med. , vol.9 , pp. 222-226
    • Tian, Y.Q.1    Kou, J.P.2    Li, L.Z.3    Yu, B.Y.4
  • 35
    • 38049053109 scopus 로고    scopus 로고
    • Toxicity testing of saponin-containing Yucca schidigera Roetzl. juice in relation to hepato- and nephrotoxicity of Narthecium ossifragum (L.) Huds
    • Wisløff H., Uhlig S., Scheie E., Loader J., Wilkins A., Flåøyen A. Toxicity testing of saponin-containing Yucca schidigera Roetzl. juice in relation to hepato- and nephrotoxicity of Narthecium ossifragum (L.) Huds. Toxicon. 2008, 51:140-150.
    • (2008) Toxicon. , vol.51 , pp. 140-150
    • Wisløff, H.1    Uhlig, S.2    Scheie, E.3    Loader, J.4    Wilkins, A.5    Flåøyen, A.6
  • 36
    • 0034999160 scopus 로고    scopus 로고
    • Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes
    • Wu F.H., Cao J.S., Jiang J.Y., Yu B.Y., Xu Q. Ruscogenin glycoside (Lm-3) isolated from Liriope muscari improves liver injury by dysfunctioning liver-infiltrating lymphocytes. J. Pharm. Pharmacol. 2000, 53:681-688.
    • (2000) J. Pharm. Pharmacol. , vol.53 , pp. 681-688
    • Wu, F.H.1    Cao, J.S.2    Jiang, J.Y.3    Yu, B.Y.4    Xu, Q.5
  • 37
    • 33846219958 scopus 로고    scopus 로고
    • Saponins, classification and occurrence in the plant kingdom
    • Vincken J.P., Heng L., de Groot A., Gruppen H. Saponins, classification and occurrence in the plant kingdom. Phytochemistry 2007, 68:275-297.
    • (2007) Phytochemistry , vol.68 , pp. 275-297
    • Vincken, J.P.1    Heng, L.2    de Groot, A.3    Gruppen, H.4
  • 38
    • 0002922819 scopus 로고
    • Effects of ruscogenin fucopyranoside on the delayed type hypersensitivity and inflammatory reactions
    • Xu Q., Wang R., Yu B.Y. Effects of ruscogenin fucopyranoside on the delayed type hypersensitivity and inflammatory reactions. J. China Pharm. Univ. 1993, 24:98-101.
    • (1993) J. China Pharm. Univ. , vol.24 , pp. 98-101
    • Xu, Q.1    Wang, R.2    Yu, B.Y.3
  • 39
    • 14644435878 scopus 로고
    • Studies on resource utilization of Chinese drug dwarf lilyturf (Ophiopogon japonicus)
    • Yu B.Y., Xu G.J. Studies on resource utilization of Chinese drug dwarf lilyturf (Ophiopogon japonicus). China Tradit. Herb. Drugs. 1995, 26:205-210.
    • (1995) China Tradit. Herb. Drugs. , vol.26 , pp. 205-210
    • Yu, B.Y.1    Xu, G.J.2
  • 40
    • 33846977371 scopus 로고    scopus 로고
    • Exploration on the modern research methodology of traditional Chinese medicine, basing on the systemic research of Radix Ophiopogonis
    • Yu B.Y. Exploration on the modern research methodology of traditional Chinese medicine, basing on the systemic research of Radix Ophiopogonis. Chin. J. Nat. Med. 2007, 5:10-14.
    • (2007) Chin. J. Nat. Med. , vol.5 , pp. 10-14
    • Yu, B.Y.1
  • 41
    • 33644671116 scopus 로고
    • Biological activities of ruscogenin 1-O- [β-d-glucopyranosyl(1→2)][β-d-xylopyranosyl(1→3)]-β-d-fucopyranoside from tuberous roots of Liriope muscari (Decne.) Baily
    • Yu B.Y., Yin X., Rong Z.Y., Yang T.M., Zhang C.H., Xu G.J. Biological activities of ruscogenin 1-O- [β-d-glucopyranosyl(1→2)][β-d-xylopyranosyl(1→3)]-β-d-fucopyranoside from tuberous roots of Liriope muscari (Decne.) Baily. J. China Pharm. Univ. 1994, 25:286-288.
    • (1994) J. China Pharm. Univ. , vol.25 , pp. 286-288
    • Yu, B.Y.1    Yin, X.2    Rong, Z.Y.3    Yang, T.M.4    Zhang, C.H.5    Xu, G.J.6
  • 42
    • 0025148631 scopus 로고
    • Comparative studies on the constituents of Ophiopogonis Tuber and its congeners. VI. Studies on the constituents of the subterranean part of Liriope spicata var. prolifera and L. muscari. (1)
    • Yu B.Y., Hirai Y., Shoji J., Xu G.J. Comparative studies on the constituents of Ophiopogonis Tuber and its congeners. VI. Studies on the constituents of the subterranean part of Liriope spicata var. prolifera and L. muscari. (1). Chem. Pharm. Bull. 1990, 38:1931-1935.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 1931-1935
    • Yu, B.Y.1    Hirai, Y.2    Shoji, J.3    Xu, G.J.4
  • 43
    • 79960837733 scopus 로고    scopus 로고
    • Application of Liriope muscari Baily saponin C in pharmacy. C.N. Patent 101352448.
    • Yuan, S.T., Sun, L., Yu, B.Y., Zhang, L.Y., Lin, S.S., Zhu, D.N., Shi, W., 2009. Application of Liriope muscari Baily saponin C in pharmacy. C.N. Patent 101352448.
    • (2009)
    • Yuan, S.T.1    Sun, L.2    Yu, B.Y.3    Zhang, L.Y.4    Lin, S.S.5    Zhu, D.N.6    Shi, W.7
  • 44
    • 77952121788 scopus 로고    scopus 로고
    • Group B oleanane triterpenoid extract containing soyasaponins I and III from soy flour induces apoptosis in Hep-G2 cells
    • Zhang W., Popovich D.G. Group B oleanane triterpenoid extract containing soyasaponins I and III from soy flour induces apoptosis in Hep-G2 cells. J. Agric. Food Chem. 2010, 58:5315-5319.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 5315-5319
    • Zhang, W.1    Popovich, D.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.