Skin cancers and other cutaneous diseases in renal transplant recipients: A single Italian center observational study

European Journal of Dermatology

Volumn 21, Issue 2, 2011, Pages 242-247

  Savoia, Paola ^a   Stroppiana, Elena ^a   Cavaliere, Giovanni ^a   Osella Abate, Simona ^a   Mezza, Elisabetta ^b   Segoloni, Giuseppe Paolo ^b   Bernengo, Maria Grazia ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MOLINETTE HOSPITAL   (Italy)

Author keywords

Cutaneous diseases; Immunosuppressant treatment; Renal transplantation; Risk factors; Skin cancer

Indexed keywords

AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; EVEROLIMUS; IMMUNOSUPPRESSIVE AGENT; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS;

ACTINIC KERATOSIS; ADULT; AGE; AGED; ANGIOMA; APHTHOUS STOMATITIS; ARTICLE; AUTOIMMUNE DISEASE; BASAL CELL CARCINOMA; CANCER RISK; CONTROLLED STUDY; DRUG ERUPTION; FEMALE; GENDER; GRAFT RECIPIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; ITALY; KAPOSI SARCOMA; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LONG TERM CARE; MACULOPAPULAR RASH; MAJOR CLINICAL STUDY; MALE; MELANOMA; OBSERVATIONAL STUDY; OCCUPATION; POSTOPERATIVE PERIOD; RISK FACTOR; SKIN CANCER; SKIN CARCINOMA; SKIN DISEASE; SKIN INFECTION; SKIN INFLAMMATION; TREATMENT DURATION; URTICARIA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, BASAL CELL; FEMALE; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; ITALY; KERATOSIS, ACTINIC; KIDNEY TRANSPLANTATION; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; RISK FACTORS; SKIN DISEASES; SKIN NEOPLASMS; YOUNG ADULT;

EID: 79960799303     PISSN: 11671122     EISSN: 19524013     Source Type: Journal    
DOI: 10.1684/ejd.2011.1272     Document Type: Article

References (24)

1. Abdelbaqi-Salhab M, Shalub S, Morgan MB. A current review of the cutaneous manifestations of renal disease. J Cutan Pathol 2003; 30: 527-38.
2. Gallagher MP, Kelly PJ, Jardine M, et al. Long-term cancer risk of immunosuppressive regimens after kidney transplantation. J Am Soc Nephrol 2010; 21: 852-8.
3. Stockfleth E, Ulrich C, Meyer T, Arndt R, Christophers E. Skin diseases following organ transplantation-Risk factors and new therapeutic approaches. Transplantation Proc 2001; 33: 1848-53.
4. Joly P, Bastuji-Garin S, Frances C, et al. Squamous cell carcinomas are associated with verrucokeratotic cutaneous lesions but not with common warts in organ-transplant patients. A case-control study. Transplantation 2010; 89: 1224-30.
5. Durando B, Reichel J. The relative effects of different systemic immunosuppressives on skin cancer development in organ transplant patients. Dermatologic Therapy 2005; 18: 1-11.
6. Euvrard S, Kanitakis J, Claudy A. Skin cancers after organ transplantation. N Engl J Med 2003; 348: 1681-91.
7. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 475-80.
8. Mantel N. Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 1966; 50: 163-70.
9. Rallis E, Limas C. Recurrent dermatitis after solitary envenomation by jellyfish partially responded to tacrolimus ointment 0.1%. J Eur Acad Dermatol Venereol 2007; 21(9): 1287-8.
10. Lally A, Casabonne D, Imko-Walczuk B, Newton R, Wojnarowska F. Prevalence of benign cutaneous disease among Oxford renal transplant recipients. Eur Acad Dermatol Venereol 2010. [Epub ahead of print]. DOI: 10.1111/j.1468-3083.2010.03814.x.
11. Lally A, Casabonne D, Waterboer T, et al. Association of seborrhoeic warts with skin cancer in renal transplant recipients. J Eur Acad Dermatol Venereol 2010; 24: 302-7.
12. Gupta AK, Bluhm R, Barlow JO, Fleischer AB Jr., Feldman SR. Prescribing practices for seborrheic dermatitis vary with the physician's specialty: implications for clinical practice. J Dermatolog Treat 2004; 15: 208-13.
13. Formicone F, Fargnoli MC, Pisani F, Rascente M, Famulari A, Peris K. Cutaneous manifestations in Italian kidney transplant recipients. Transplant Proc 2005; 37: 2527-8.
14. Arness T, Pedersen R, Dierkhising R, Kremers W, Patel R. Varicella zoster virus-associated disease in adult kidney transplant recipients: incidence and risk-factor analysis. Transpl Infect Dis 2008; 10: 260-8.
15. Abdelaziz AM, Mahmoud KM, Elsawy EM, Bakr MA. Nail changes in kidney transplant recipients. Nephrol Dial Transplant 2010; 25: 274-7.
16. Fuente MJ, Sabat M, Roca J, Lauzurica R, Fernández-Figueras MT, Ferrándiz C. A prospective study of the incidence of skin cancer and its risk factors in a Spanish Mediterranean population of kidney transplant recipients. Br J Dermatol 2003; 149: 1221-6.
17. Wisgerhof HC, Edelbroek JR, De Fijter JW, et al. Subsequent squamous-and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010; 89: 1231-8.
18. Ingvar A, Smedby KE, Lindelöf B, et al. Immunosuppressive treatment after solid organ transplantation and risk of post-transplant cutaneous squamous cell carcinoma. Nephrol Dial Transplant 2010; 25: 2764-71.
19. Frances C, Marcelin AG, Legendre CH, et al. The impact of preexisting or acquired Kaposi's sarcoma herpesvirus infection in kidney transplant recipients on morbidity and survival. Am J Transplant 2009; 9: 2580-6.
20. Keller B, Braathen LR, Marti HP, Hunger RE. Skin cancers in renal transplant recipients: a description of the renal transplant cohort in Bern. Swiss Med Wkly 2010; 140: w13036. doi: 10.4414/smw.2010.13036.
21. Ulrich C, Jürgensen JS, Degen A, et al. Prevention of nonmelanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study. Br J Dermatol 2009; 161: 78-84.
22. Lacour JP. Carcinogenesis of basal cell carcinomas: genetics and molecular mechanisms. Br J Dermatol 2002; 146(Suppl. 61): 17-9.
23. Kepron C, Reis P, Bharadwaj R, Shaw J, Kamel-Reid S, Ghazarian D. Identification of genomic predictors of non-melanoma skin cancer in solid organ transplant recipients. Eur J Dermatol 2009; 19: 278-80.
24. Salgo R, Gossmann J, Schofer H, et al. Switch to a Sirolimus-based immunosuppression in long-term renal transplant recipient: reduced rate of (pre) malignancies and non melanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transplant 2010; 10: 1385-93.