Interleukin-6 reduces NMDA-induced Ca 2+ overload via prevention of Ca 2+ release from intracellular store

International Journal of Neuroscience

Volumn 121, Issue 8, 2011, Pages 423-429

  Sun, Xiao Min ^a   Lu, Jian Hua ^a   Qiu, Yi Hua ^a,b   Liu, Zhan ^a   Wang, Xiao Qin ^a   Peng, Yu Ping ^a  

^a NANTONG MEDICAL COLLEGE   (China)

^b NANTONG UNIVERSITY   (China)

Author keywords

Ca 2+ overload; Cerebellar granule neurons; Interleukin 6; NMDA

Indexed keywords

CALCIUM ION; N METHYL DEXTRO ASPARTIC ACID; RECOMBINANT INTERLEUKIN 6;

ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CEREBELLAR GRANULE NEURON; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; EXTRACELLULAR CALCIUM; FLUORESCENCE; INTRACELLULAR SIGNALING; MOLECULAR DYNAMICS; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PROTEIN FUNCTION; RAT;

ANILINE COMPOUNDS; ANIMALS; ANIMALS, NEWBORN; BORON COMPOUNDS; CALCIUM; CELLS, CULTURED; CEREBELLUM; CHELATING AGENTS; DRUG INTERACTIONS; EGTAZIC ACID; GLUTAMIC ACID; INTERLEUKIN-6; INTRACELLULAR SPACE; NAPHTHYRIDINES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS, NONPARAMETRIC; XANTHENES;

EID: 79960797162     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2011.556280     Document Type: Article

References (24)

1. Ali C. Nicole O. Docagne F. Lesne S. MacKenzie E.T. Nouvelot A. et al. 2000 Ischemia-induced interleukin-6 as a potential endogenous neuroprotective cytokine against NMDA receptor-mediated excitotoxicity in the brain Journal of Cerebral Blood Flow & Metabolism 20 6 956-966
2. Baker D.G. Ekhator N.N. Kasckow J.W. Hill K.K. Zoumakis E. Dashevsky B.A. et al. 2001 Plasma and cerebrospinal fluid interleukin-6 concentrations in posttraumatic stress disorder Neuroimmunomodulation 9 4 209-217
3. Baranzini S.E. Elfstrom C. Chang S.Y. Butunoi C. Murray R. Higuchi R. et al. 2000 Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression Journal of Immunology 165 11 6576-6582
4. Conroy S.M. Nguyen V. Quina L.A. Blakely-Gonzales P. Ur C.Netzeband J.G.et al. 2004 Interleukin-6 produces neuronal loss in developing cerebellar granule neuron cultures Journal of Neuroimmunology 155 1 2 43-54
5. Gadient R.A. Otten U. 1993 Differential expression of interleukin-6 IL-6 and interleukin-6 receptor IL-6R mRNAs in rat hypothalamus Neuroscience Letters6 153 1 13-16
6. Gadient R.A. Otten U. 1994 Identification of interleukin-6 IL-6-expressing neurons in the cerebellum and hippocampus of normal adult rats Neuroscience Letters 182 2 243-246
7. Gruol D.L. Nelson T.E. 2005 Purkinje neuron physiology is altered by the inflammatory factor interleukin-6 Cerebellum 4 3 198-205
8. Hama T. Kushirna Y. Miyamoto M. 1991 Interleukin-6 improves the survival of mesencephalic catecholarninergic and septal cholinergic neurons from postnatal two-week-old rats in cultures Neuroscience 40 2 445-452
9. Hirota H. Kiyama H. Kishimoto T. Taga T. 1996 Accelerated nerve regeneration in mice by upregulated expression of interleukin IL 6 and IL-6 receptor after trauma Journal of Experimental Medicine 183 6 2627-2634
10. Loddick S.A. Turnbull A.V. Rothwell N.J. 1998 Cerebral interleukin-6 is neuroprotective during permanent focal cerebral ischemia in the rat Journal of Cerebral Blood Flow & Metabolism 18 2 176-179
11. Maeda Y. Matsumoto M. Hori O. Kuwabara K. Ogawa S. Yan S.D. et al. 1994 Hypoxia/reoxygenation-mediated induction of astrocyte interleukin 6: A paracrine mechanism potentially enhancing neuron survival Journal of Experimental Medicine 180 6 2297-2308
12. Murphy P.G. orthwick L.A. Altares M. 2000 Reciprocal actions of interleukin-6 and brain-derived neurotrophic factor on rat and mouse primary sensory neurons European Journal of Neuroscience 12 6 1891-1899
13. Murphy P.G. Grondin J. Altares M. 1995 Induction of intereukin-6 in axotomized sensory neurons Journal of Neuroscience 15 7 5130-5138
14. + release in alzheimers disease mouse neurons Callular Signaling 22 3 519-526
15. Pavelko K.D. Howe C.L. Drescher K.M. 2003 Interleukin-6 protects anterior hore neurons from lethal virus-induced injury Journal of Neuroscience 23 2 481-492
16. Peng Y.P. Qiu Y.H. Lu J.H. Wang J.J. 2005 Interleukin-6 protects cultured cerebellar granule neurons against glutamateinduced neurotoxicity Neuroscience Letters 374 3 192-196
17. Qiu Z. Gruol D.L. 2003 Interleukin-6 β-amyloid peptide and NMDA interactions in rat cortical neurons Journal of Neuroimmunology 139 1 2 51-57
18. Reale M. Iarlori C. Gambi F. Lucci I. Salvatore M. Gambi D. 2005 Acetylcholinesterase inhibitors effects on oncostatin- M, interleukin-1 beta and interleukin-6 release from lymphocytes of alzheimers disease patients Experimental Gerontology 40 3 165-171
19. Schöbitz B. De Kloet E.R. Sutanto W. Holsboer F. 1993 Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain European Journal of Neuroscience 5 11 1426-1435
20. Thier M. Marz P.Otten U. Weis J. Rose-John S. 1999 Interleukin-6 IL-6 and its soluble receptor support survival of sensory neurons Journal of Neuroscience Research 55 4 411-422
21. Toulmond S. Vige X. Fage D. Benavides J. 1992 Local infusion of interleukin-6 attenuates the neurotoxic effects of NMDA on rat striatal cholinergic neurons Neuroscience Letters 144 1 2 49-52
22. Van Wagoner N.J. Benveniste E.N. 1999 Interleukin-6 expression and regulation in astrocytes Journal of Neuroimmunology 100 1 2 124-139
23. Verkhratsky A. PetersenO.H. 2002 The endoplasmic reticulum as an integrating signaling organelle: From neuronal signaling to neuronal death European Journal of Pharmacology 447 2 3 141-154
24. Wang X.C. Qiu Y.H. Peng Y.P. 2007 Interleukin-6 protects cerebellar granule neurons from NMDA-induced neurotoxicity Sheng Li Xue Bao 59 2 150-156