Sh3pxd2b mice are a model for craniofacial dysmorphology and otitis media

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Yang, Bin ^a   Tian, Cong ^b   Zhang, Zhi guang ^a   Han, Feng chan ^b   Azem, Rami ^b   Yu, Heping ^b   Zheng, Ye ^b   Jin, Ge ^c   Arnold, James E ^b   Zheng, Qing Y ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROTEIN TYROSINE KINASE; SH3 AND PX DOMAIN 2B PROTEIN; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; AUTACOID; FAD49 PROTEIN, MOUSE; PHOSPHOLIPID TRANSFER PROTEIN; TLR2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDITORY TUBE; CONTROLLED STUDY; CRANIOFACIAL DEVELOPMENT; CRANIOFACIAL MALFORMATION; CRANIOFACIAL MORPHOLOGY; DEVELOPMENTAL STAGE; EUKARYOTIC FLAGELLUM; GENE EXPRESSION REGULATION; GOBLET CELL; HEARING IMPAIRMENT; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE EAR MUCOSA; MOUSE; MOUSE MUTANT; MUTATIONAL ANALYSIS; MUTATOR GENE; NONHUMAN; ONSET AGE; OTITIS MEDIA; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SH3 AND PX DOMAIN 2B GENE; UPREGULATION; ANIMAL; AUDITORY THRESHOLD; DISEASE MODEL; EVOKED BRAIN STEM AUDITORY RESPONSE; GENETICS; HEARING LOSS; HUMAN; INFLAMMATION; METABOLISM; MIDDLE EAR; MUCOSA; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE; PHYSIOLOGY; TIME; ULTRASTRUCTURE;

ANIMALIA; MUS;

ANIMALS; AUDITORY THRESHOLD; CRANIOFACIAL ABNORMALITIES; DISEASE MODELS, ANIMAL; EAR, MIDDLE; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GENE EXPRESSION REGULATION; HEARING LOSS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MICE; MICE, MUTANT STRAINS; MUCOUS MEMBRANE; OTITIS MEDIA; PHENOTYPE; PHOSPHOLIPID TRANSFER PROTEINS; TIME FACTORS; TOLL-LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960766400     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022622     Document Type: Article

References (47)

1. Stool SE BA, Berman S, Carney CJ, Culpepper L, et al. (1994) Otitis Media with Effusion in Young Children Clinical Practice Guideline.
2. Alho OP, Oja H, Koivu M, Sorri M, (1995) Chronic otitis media with effusion in infancy. How frequent is it? How does it develop? Arch Otolaryngol Head Neck Surg 121: 432-436.
3. Rosenfeld RM, Culpepper L, Doyle KJ, Grundfast KM, Hoberman A, et al. (2004) Clinical practice guideline: Otitis media with effusion. Otolaryngol Head Neck Surg 130: S95-118.
4. Paradise JL, Rockette HE, Colborn DK, Bernard BS, Smith CG, et al. (1997) Otitis media in 2253 Pittsburgh-area infants: prevalence and risk factors during the first two years of life. Pediatrics 99: 318-333.
5. Engel JA, Straetemans M, Zielhuis GA, (2005) Birth characteristics and recurrent otitis media with effusion in young children. Int J Pediatr Otorhinolaryngol 69: 533-540.
6. Marchant CD, Shurin PA, Turczyk VA, Wasikowski DE, Tutihasi MA, et al. (1984) Course and outcome of otitis media in early infancy: a prospective study. J Pediatr 104: 826-831.
7. Klein JO, (2000) The burden of otitis media. Vaccine 19 (Suppl 1): S2-8.
8. Cunsolo E, Marchioni D, Leo G, Incorvaia C, Presutti L, (2010) Functional anatomy of the Eustachian tube. Int J Immunopathol Pharmacol 23: 4-7.
9. Pau HW, Sievert U, Just T, Sade J, (2009) Pressure changes in the human middle ear without opening the eustachian tube. Acta Otolaryngol 129: 1182-1186.
10. Makibara RR, Fukunaga JY, Gil D, (2010) Eustachian tube function in adults with intact tympanic membrane. Braz J Otorhinolaryngol 76: 340-346.
11. Doyle WJ, Swarts JD, (2010) Eustachian tube-Tensor veli palatini muscle-cranial base relationships in children and adults: an osteological study. Int J Pediatr Otorhinolaryngol 74: 986-990.
12. Sehhati-Chafai-Leuwer S, Wenzel S, Bschorer R, Seedorf H, Kucinski T, et al. (2006) Pathophysiology of the Eustachian tube-relevant new aspects for the head and neck surgeon. J Craniomaxillofac Surg 34: 351-354.
13. Granstrom G, (2009) Middle ear infections. Periodontol 2000 49: 179-193.
14. Kemaloglu YK, Kobayashi T, Nakajima T, (2000) Associations between the eustachian tube and craniofacial skeleton. Int J Pediatr Otorhinolaryngol 53: 195-205.
15. Visosky AM, Johnson J, Bingea B, Gurney T, Lalwani AK, (2003) Otolaryngological manifestations of cleidocranial dysplasia, concentrating on audiological findings. Laryngoscope 113: 1508-1514.
16. Richardson MA, Donaldson JA, (1981) Middle ear fluid. Am Fam Physician 23: 159-163.
17. Di Francesco R, Paulucci B, Nery C, Bento RF, (2008) Craniofacial morphology and otitis media with effusion in children. Int J Pediatr Otorhinolaryngol 72: 1151-1158.
18. Di Francesco RC, Sampaio PL, Bento RF, (2007) Correlation between otitis media and craniofacial morphology in adults. Ear Nose Throat J 86: 738-743.
19. Todd NW, (1998) Cranial anatomy and otitis media: a cadaver study. Am J Otol 19: 558-564.
20. Flynn T, Moller C, Jonsson R, Lohmander A, (2009) The high prevalence of otitis media with effusion in children with cleft lip and palate as compared to children without clefts. Int J Pediatr Otorhinolaryngol.
21. Sheahan P, Miller I, Sheahan JN, Earley MJ, Blayney AW, (2003) Incidence and outcome of middle ear disease in cleft lip and/or cleft palate. Int J Pediatr Otorhinolaryngol 67: 785-793.
22. Purzycki A, Thompson E, Argenta L, David L, (2009) Incidence of otitis media in children with deformational plagiocephaly. J Craniofac Surg 20: 1407-1411.
23. Buschman MD, Bromann PA, Cejudo-Martin P, Wen F, Pass I, et al. (2009) The novel adaptor protein Tks4 (SH3PXD2B) is required for functional podosome formation. Mol Biol Cell 20: 1302-1311.
24. Mao M, Thedens DR, Chang B, Harris BS, Zheng QY, et al. (2009) The podosomal-adaptor protein SH3PXD2B is essential for normal postnatal development. Mamm Genome 20: 462-475.
25. Diaz B, Shani G, Pass I, Anderson D, Quintavalle M, et al. (2009) Tks5-dependent, nox-mediated generation of reactive oxygen species is necessary for invadopodia formation. Sci Signal 2: ra53.
26. Gianni D, Diaz B, Taulet N, Fowler B, Courtneidge SA, et al. (2009) Novel p47(phox)-related organizers regulate localized NADPH oxidase 1 (Nox1) activity. Sci Signal 2: ra54.
27. Weaver AM, (2009) Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins. Sci Signal 2: pe56.
28. Iqbal Z, Cejudo-Martin P, de Brouwer A, van der Zwaag B, Ruiz-Lozano P, et al. (2010) Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome. Am J Hum Genet 86: 254-261.
29. Han F, Yu H, Zhang J, Tian C, Schmidt C, et al. (2009) Otitis media in a mouse model for Down syndrome. Int J Exp Pathol 90: 480-488.
30. Han F, Yu H, Tian C, Li S, Jacobs MR, et al. (2009) Role for Toll-like receptor 2 in the immune response to Streptococcus pneumoniae infection in mouse otitis media. Infect Immun 77: 3100-3108.
31. Green MC, (1952) A rapid method for clearing and staining specimens for the demonstration of bone. The Ohio Journal of Science 52 (1): 31-33.
32. Richtsmeier JT, Baxter LL, Reeves RH, (2000) Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice. Dev Dyn 217: 137-145.
33. Zheng QY, Johnson KR, Erway LC, (1999) Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 130: 94-107.
34. Lee YC, Kim C, Shim JS, Byun JY, Park MS, et al. (2008) Toll-like receptors 2 and 4 and their mutations in patients with otitis media and middle ear effusion. Clin Exp Otorhinolaryngol 1: 189-195.
35. Ungkanont K, Charuluxananan S, Komoltri C, Association of otoscopic findings and hearing level in pediatric patients with otitis media with effusion (2010) Int J Pediatr Otorhinolaryngol 74: 1063-1066.
36. Kemaloglu YK, Beder L, Sener T, Goksu N, (2000) Tympanometry and acoustic reflectometry in ears with chronic retraction without effusion. Int J Pediatr Otorhinolaryngol 55: 21-27.
37. Trune DR, Zheng QY, (2009) Mouse models for human otitis media. Brain Res 1277: 90-103.
38. Depreux FF, Darrow K, Conner DA, Eavey RD, Liberman MC, et al. (2008) Eya4-deficient mice are a model for heritable otitis media. J Clin Invest 118: 651-658.
39. Harimaya A, Fujii N, Himi T, (2009) Preliminary study of proinflammatory cytokines and chemokines in the middle ear of acute otitis media due to Alloiococcus otitidis. Int J Pediatr Otorhinolaryngol 73: 677-680.
40. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, et al. (2009) TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun 15: 205-215.
41. Samuel EA, Burrows A, Kerschner JE, (2008) Cytokine regulation of mucin secretion in a human middle ear epithelial model. Cytokine 41: 38-43.
42. Silveira Netto LF, da Costa SS, Sleifer P, Braga ME, (2009) The impact of chronic suppurative otitis media on children's and teenagers' hearing. Int J Pediatr Otorhinolaryngol 73: 1751-1756.
43. Zheng QY, Hardisty-Hughes R, Brown SD, (2006) Mouse models as a tool to unravel the genetic basis for human otitis media. Brain Res 1091: 9-15.
44. Juhn SK, Jung TT, (1985) Inflammatory changes reflected in middle ear effusion in otitis media. Auris Nasus Larynx 12 (Suppl 1): S63-66.
45. Lin J, Tsuboi Y, Rimell F, Liu G, Toyama K, et al. (2003) Expression of mucins in mucoid otitis media. J Assoc Res Otolaryngol 4: 384-393.
46. Saunders J, Murray M, Alleman A, (2011) Biofilms in chronic suppurative otitis media and cholesteatoma: scanning electron microscopy findings. Am J Otolaryngol 32: 32-37.
47. Jang CH, Park H, Choi CH, Cho YB, Park IY, (2010) Efficacy of transnasal nebulized surfactant on experimental otitis media with effusion in guinea pig. Int J Pediatr Otorhinolaryngol 74: 71-74.