Expression of mucins in mucoid otitis media

JARO - Journal of the Association for Research in Otolaryngology

Volumn 4, Issue 3, 2003, Pages 384-393

  Lin, Jizhen ^a,d   Tsuboi, Yasuhiro ^a   Rimell, Frank ^a   Liu, George ^b   Toyama, Katsuhiro ^a   Kawano, Hirokazu ^a   Paparella, Michael M ^b   Ho, Samuel B ^a,c  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Paparella Ear Head and Neck Institute PA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d LRB   (United States)

Author keywords

Humans; Mucins; Mucoid otitis media; Mucous cell metaplasia

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MESSENGER RNA; MUCIN; MUCIN 4; MUCIN 5B; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENETICS; GOBLET CELL; HEARING LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INFLAMMATORY CELL; MACROPHAGE; METAPLASIA; MIDDLE EAR; MIDDLE EAR EFFUSION; MONOCYTE; MUCOID OTITIS MEDIA; MUCOSA; OTITIS MEDIA; PATHOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOUND TRANSMISSION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIVISION; EAR, MIDDLE; GENE EXPRESSION; GOBLET CELLS; HUMANS; MACROPHAGES; METAPLASIA; MONOCYTES; MUCINS; MUCOUS MEMBRANE; OTITIS MEDIA; RNA, MESSENGER;

EID: 0141506125     PISSN: 15253961     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10162-002-3023-9     Document Type: Article

References (39)

1. ASKER N, AXELSSON MA, OLOFSSON S-O, HANSSON GC. Dimerization of the human MUC2 mucin in the endoplasmic reticulum is followed by a N-glycosylation-dependent transfer of the mono- and dimers to the Golgi apparatus. J. Biol. Chem. 273:18857-18863, 1998.
2. CARRAWAY KL 3RD, ROSSI EA, KOMATSU M, PRICE-SCHIAVI SA, HUANG PM, GUY PM, CARVAJAL ME, FREGIEN N, CARRAWAY CA, CARRAWAY KL. An intramembrane modulator of the ErbB2 receptor tyrosine kinase that potentiates neuregulin signaling. J. Biol. Chem. 274:5263-5266, 1999.
3. CARRAWAY KL, PRICE-SCHIAVI SA, KOMATSU M, IDRIS N, PEREZ A, LI P, JEPSON S, ZHU X, CARVAJAL ME, CARRAWAY CA. Multiple facets of sialomucin complex/MUC4, a membrane mucin and erbb2 ligand, in tumors and tissues (Y2K update). Front. Biosci. 5:D95-D107, 2000.
4. CHUNG MH, CHOI JY, LEE WS, KIM HN, YOON JH. Compositional difference in middle ear effusion: mucous versus serous. Laryngoscope 112:152-155, 2002.
5. DEKKER J, STROUS GL. Covalent oligomerization of rat gastric mucin occurs in the rough endoplasmic reticulum, is N-glycosylation-dependent, and precedes initial O-glycosylation. J. Biol. Chem. 265:18116-18122, 1990.
6. DESSEYN JL, GUYONNET-DUPERAT V, PORCHET N, AUBERT JP, LAINE A. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family. J. Biol. Chem. 272:3168-3178, 1997.
7. DUFOSSE J, PORCHET N, AUDIE J-P, GUYONNET-DUPERAT V, LAINE A, VAN-SEUNINGEN I, MARRAKCHI S, DEGAND P, AUERT J-P. Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15. Biochem. J. 293:329-337, 1993.
8. GATES GA, KLEIN JO, LIM DJ, MOGI G, OGRA PL, PARAPELLA MM, PARADISE JL, TOS M. Recent advances in otitis media. I. Definitions, terminology, and classification of otitis media. Ann. Otol. Rhinol. Laryngol. Suppl. 188:8-18, 2002.
9. GENDLER SJ, SPICER AP. Epithelial mucin genes. Annu. Rev. Physiol. 57:607-634, 1995.
10. HO SB, SHEKELS LL, TORIBARA NW, KIM YS, LYFTOGT C, CHERWITZ DL, NIEHANS GA. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium. Cancer Res. 55:2681-2690, 1995.
11. HUTTON DA, FOGG FJ, KUBBA H, BIRCHALL JP, PEARSON JP. Heterogeneity in the protein cores of mucins isolated from human middle ear effusions: evidence for expression of different mucin gene products. Glycoconjugate J. 15:283-291, 1998.
12. KAWANO H, HARUTA A, TSUBOI Y, KIM Y, SCHACHERN PA, PAPARELLA J, LIN J. Induction of mucous cell metaplasia by tumor necrosis factor alpha in rat middle ear: the pathologic basis for mucin hyperproduction in mucoid otitis media. Ann. Otol. Rhinol. Laryngol. 111:415-422, 2002.
13. KAWANO H, PAPARELLA MM, HO SB, SCHACHERN P, MORIZONO N, LE J, LIN J. Identification of MUC5B mucin gene in human middle ear with chronic otitis media. Laryngoscope 110:668-673, 2000.
14. KEATES AC, NUNES DP, AFDHAL NH, TROXLER RF, OFFNER GD. Molecular cloning of a major human gall bladder mucin: complete C-terminal sequence and genomic organization of MUC5B. Biochem. J. 324:295-303, 1997.
15. KIM HY, AHN BY, CHO Y. Structural basis for the inactivation of retinoblastoma tumor suppressor by SV40 large T antigen. EMBO J. 20:295-304, 2001.
16. KIM KC, WASANO K, NILES RM, SCHUSTER JE, STONE PJ, BRODY JS. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 84:9304-9308, 1987.
17. KIM YS, GUM JR JR. Diversity of mucin genes, structure, function, and expression. Gasteroenterology 109:999-1001, 1995.
18. LEINONEN MK. Detection of pneumococcal capsular polysaccharide antigens by latex agglutination, counterimmunoelectrophoresis, and radioimmunoassay in middle ear exudates in acute otitis media. J. Clin. Microbiol. 11:135-140, 1980.
19. LI JD, DOHRMAN AF, GALLUP M, MIYATA S, GUM JR, KIM Y, NADEL JA, PRINCE A, BASBAUM CB. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc. Natl. Acad. Sci. USA 94:967-972, 1997.
20. LI JD, FENG W, GALLUP M, KIM JH, GUM J, KIM Y, BASBAUM C. Activation of NF-kappaB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells. Proc. Natl. Acad. Sci. USA 95:5718-5723, 1998.
21. LI W, LIN J, ADAMS GL, JUHN SK. Expression of inducible nitric oxide synthase (iNOS) in middle ear epithelial cells by IL-1beta and TNF-alpha. Int. J. Pediatr. Otorhinolaryngol. 55:91-98, 2000.
22. LIM DJ. Normal and pathological mucosa of the middle ear and Eustachian tube. Clin. Otolaryngol. 4:213-234, 1979.
23. LIM DJ, HARUTA A, KAWANO H, HO SB, ADAMS GL, JUHN SK, KIM YK. Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-α: potential cause for mucoid otitis media. J. Infect. Dis. 182:882-887, 2000.
24. LIN J, PAPARELLA MM, HO SB. RNA analysis on autopsy eustachian tube tissues: an addition to temporal bone histopathology. Acta Otolaryngol. 119:787-795, 1998.
25. LIN J, TSUBOI Y, PAN W, GIEBINK GS, ADAMS GL, KIM Y. Analysis by cDNA microarrays of altered gene expression in middle ears of rats following pneumococcal infection. Int. J. Pediatr. Otorhinolaryngol. 65:203-211, 2002.
26. LIN J, TSUPRUN V, KAWANO H, PAPARELLA MM, ZHANG Z, ANWAY RE, Ho SB. Characterization of mucins in human middle ear and Eustachian tube. Am. J. Physiol. 280:L1157-1167, 2001.
27. LIN J, VAMBUTAS A, HARUTA A, PAPARELLA MM, GIEBINK GS, KIM Y. Pneumococcus activation of the 5-lipoxygenase pathway and production of glycoproteins in the middle ear of rats. J. Infect. Dis. 179:1145-1151, 1999.
28. MOON SK, YOO JH, KIM HN, LIM DJ, CHUNG MH. Effects of retinoic acid, triiodothyronine and hydrocortisone on mucin and lysozyme expression in cultured human middle ear epithelial cells. Acta Otolaryngol. 120:944-949, 2000.
29. OVESEN T, LEDET T. Bacteria and endotoxin in middle ear fluid and the course of secretory otitis media. Clin. Otolaryngol. 17:531-534, 1992.
30. REDDY MS, MURPHY TF, FADEN HS, BERNSTEIN JM. Middle ear mucin glycoprotein: purification and interaction with nontypable Haemophilus influenzae and Moraxella catarrhalis. Otolaryngol. Head Neck Surg. 116:175-180, 1997.
31. ROSE AS, PRAZMA J, RANDELL SH, BAGGETT HC, PILLSBURY JC. Lipopolysaccharide increases release of mucin in a rat model of chronic otitis media with effusion. Assoc. Res. Otolaryngol. Abs. 37:, 1996.
32. ROSE MC, GENDLER SJ. Basic mechanisms and clinical perspectives. In: GENDLER D, ROGERS M (eds) Airway Mucus. Birkhauser Publishing Limited, Boston, pp 41-66, 1997.
33. SHANKAR V, PICHAN P, EDDY JR RL, TONK V, NOWAR N, SAIT SN, SHOWS TB, SGHULTZ RE, GOTWAY G, ELKINS RC, GILMORE MS, SACHDEV GP. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus. Am. J. Respir. Cell. Mol. Biol. 16:232-241, 1997.
34. SHEKELS LL, ANWAY RE, LIN J, KENNEDY MW, GARSIDE P, LAWRENCE SB, HO SB. Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Dig. Dis. Sci. 46:1757-1764, 2001.
35. SHENG Z, WU K, CARRAWAY KL, FREGIEN N. Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. A new member of the epidermal growth factor superfamily. J. Biol. Chem. 267:16341-16346, 1992.
36. TOS M, BAK-PEDERSEN K. Secretory otitis. Histopathology and goblet-cell density in the eustachian tube and middle ear in children. J. Laryngol. Otol. 90:475-485, 1976.
37. Tos M, BAK-PEDERSEN K. Goblet cell population in the pathological middle ear and eustachian tube of children and adults. Ann. Otol. Rhinol. Laryngol. 86:209-218, 1977.
38. TSUBOI Y, KIM Y, PAPARELLA MM, CHEN NQ, SCHACHERN P, LIN J. Pattern changes of mucin gene expression with pneumococcal otitis media. Int. J. Pediatr. Otolaryngol. 61:23-30, 2002.
39. WANG B, LIM DJ, HAN J, KIM YS, BASBAUM CB, LI JD. Novel cytoplasmic proteins of nontypable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J. Biol. Chem. 277:949-957, 2002.