Pharmacokinetics and Effects of Alkalization During Oral and Intravenous Administration of Naproxen in Horses

Journal of Equine Veterinary Science

Volumn 31, Issue 8, 2011, Pages 456-462

  Cagnardi, Petra ^a   Gallo, Martina ^a   Zonca, Annalisa ^a   Carli, Silvano ^a   Villa, Roberto ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Alkalization; Horse; Kinetics; Naproxen; NSAID

Indexed keywords

ANIMALIA; CONGIOPODIDAE; EQUIDAE;

EID: 79960750106     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2011.03.019     Document Type: Article

References (30)

1. Dirikolu L., Woods W.E., Boyles J., Lehner A.F., Harkins J.D., Fisher M., et al. Nonsteroidal anti-inflammatory agents and musculoskeletal injuries in Thoroughbred racehorses in Kentucky. J Vet Pharmacol Ther 2009, 32:271-279.
2. Kallings P. Nonsteroidal anti-inflammatory drugs. Vet Clin North Am Equine Pract 1993, 9:523-541.
3. Barragry T.B. Nonsteroidal and steroidal anti-inflammatory drugs in horses. Veterinary drug therapy 1994, Lea & Febiger, Phila., PA. 1st ed.
4. Lees P. The analgesic, antipyretic, anti-inflammatory drugs. Veterinary pharmacology and therapeutics 2009, 457-492. Iowa State University Press, Ames, IA. 9th edition. J.E. Riviere, M.G. Papich (Eds.).
5. Burke A., Smyth E.M., Fitzgerald G.A. Chapter 26. Analgesic-antypiretic and anti-inflammatory agents; pharmacotherapy of gout. Goodman & Gilman's the pharmacological basis of therapeutics 2006, McGraw-Hill Companies, New York, NY. 11th ed. L.L. Brunton, J.S. Lazo, K.L. Parker (Eds.).
6. Sweetman S.C. Martindale: the complete drug reference 2005, Pharmaceutical Press, London, p. 65-6. 34th ed.
7. Santi G. Identificazione di anti-infiammatori non steroidei nelle urine di cavallo sportivo. Chimica e tecnologia farmaceutiche 1999, Università di Milano, Anno Accademico 1998-1999, Milano, Italy. L. Tesi di (Ed.).
8. Lees P., Higgins A.J. Clinical pharmacology and therapeutic uses of non-steroidal anti-inflammatory drugs in the horse. Equine Vet J 1985, 17:83-96.
9. Goodrich L.R., Nixon A.J. Medical treatment of osteoarthritis in the horse. A review. Vet J 2006, 171:51-69.
10. Plumb D.C. Plumb's veterinary drug handbook 2008, Blackwell Publishing Professional, Ames, IA, p. 645. 6th ed.
11. Moses V.S., Bertone A.L. Nonsteroidal anti-inflammatory drugs. Vet Clin North Am Equine Pract 2002, 18:21-37.
12. Lees P., Landoni M.F., Giraudel J., Toutain P.L. Pharmacodynamics and pharmacokinetics of non-steroidal anti-inflammatory drugs in species of veterinary interest. J Vet Pharmacol Ther 2004, 27:479-490.
13. Lees P., Landoni M.F., Giraudel J., Toutain P.L. PK/PD integration and PK/PD modelling of non-steroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther 2004, 27:491-502.
14. Toutain P.L., Lees P. Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine. J Vet Pharmacol Ther 2004, 24:467-477.
15. Bishop D., Edge J., Davis C., Goodman C. Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability. Med Sci Sports Exer 2004, 36:807-813.
16. Douroudos, Fatouros G., Gourgoulis V., Jamurtas A.Z., Tsitsios T., Hatzinikolaou A., et al. Dose-related effects of prolonged NaHCO3 ingestion during high-intensity exercise. Med Sci Sports Exer 2006, 38:1746-1753.
17. Kline K.H. " Milkshakes" for the horse. J Equine Vet Sci 2004, 24:374-378.
18. Lawrence L., Kline K., Miller-Graber P., Siegel E., Kurcz E., Fisher M., et al. Effect of sodium bicarbonate on racing Standardbreds. J Anim Sci 1990, 68:673-677.
19. Harkins J.D., Kamerling S.G. Effects of induced alkalosis on performance in Thoroughbreds during a 1600-m race. Equine Vet J 1992, 24:94-98.
20. Kline K.H., Foreman J.H., Hanson M.S., Frey L.P. Changes in blood gases and electrolytes of horses given varying doses of sodium bicarbonate. J Equine Vet Sci 1995, 15:487-491.
21. Schuback K., Essen-Gustavsson B., Persson S.G. Effect of sodium bicarbonate administration on metabolic responses to maximal exercise. Equine Vet J 2002, 34:539-544.
22. Suh H., Jun H.W., Lu G.W. Fluorimetric high performance liquid chromatography for quantisation of naproxen in serum. J Liq Chromatogr 1995, 18:3105-3115.
23. Villa R., Prandini E., Caloni F., Carli S. Serum protein binding of some sulphonamides, quinolones and fluoroquinolones in farm and domestic animals. J Vet Pharmacol Ther 1997, 20(Suppl 1):34-35.
24. Yamaoka K., Nakagawa T., Uno T. Application of Akaike's information criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm 1978, 6:165-175.
25. Gibaldi M., Perrier D. Pharmacokinetics 1982, Marcel Dekker Inc, New York.
26. Lam F.C., Hung C.T., Perrier D.G. Estimation of variance for harmonic mean half-lives. J Pharm Sci 1985, 74:229-231.
27. Soma L.R., Uboh C.E., Rudy J.A., Perkowski S.Z. Plasma and synovial fluid kinetics, disposition, and urinary excretion of naproxen in horses. Am J Vet Res 1995, 56:1075-1080.
28. Cuniberti B, Odore R, Barbero R, Cagnardi P, Badino P, Girardi C, et al. In vitro and ex vivo pharmacodynamics of selected NSAIDs in equine whole blood. Vet J doi: 10.1016/j.tvjl.2011.03.016.
29. Regolamento per il Controllo delle Sostanze Proibite-Unione Nazionale Incremento Razze Equine (U.N.I.R.E.) (D.M. n° 797 del 16-10-2002).
30. Young L, Yeow T. Naproxen: excretion and metabolism in equine. In Proceedings of the 5th International Conference on control of the use of drugs in racehorses; June 12-16, 1983; Toronto, Canada. p. 200-8.