Dose-related effects of prolonged NaHCO3 ingestion during high-intensity exercise

Medicine and Science in Sports and Exercise

Volumn 38, Issue 10, 2006, Pages 1746-1753

  Douroudos, Ioannis I ^a   Fatouros, Ioannis G ^a   Gourgoulis, Vassilios ^b   Jamurtas, Athanasios Z ^a   Tsitsios, Tilemaxos ^c   Hatzinikolaou, Athanasios ^b   Margonis, Konstantinos ^a   Mavromatidis, Kontantinos ^c   Taxildaris, Kiriakos ^a,d  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b UNIVERSITY OF THESSALY   (Greece)

^c General Hospital of Komotini   (Greece)

^d Dept of Physical Education and Sport Science ^*  (Greece)

Author keywords

Acid base balance; Anaerobic exercise; Metabolic alkalosis; Sodium bicarbonate

Indexed keywords

BICARBONATE; LACTIC ACID; POTASSIUM ION; SODIUM ION;

ACID BASE BALANCE; ADULT; ANAEROBIC EXERCISE; ANTHROPOMETRY; ARTERIAL PH; ARTICLE; CARBON DIOXIDE TENSION; CONTROLLED STUDY; ERGOMETER; ERGOMETRY; EXERCISE; HUMAN; HUMAN EXPERIMENT; MALE; METABOLIC ALKALOSIS; NORMAL HUMAN; OXYGEN TENSION; PERFORMANCE; RANDOMIZATION; WINGATE TESTING;

ACID-BASE EQUILIBRIUM; ACIDOSIS, LACTIC; ADULT; ALKALOSIS; DIETARY SUPPLEMENTS; EXERCISE; HUMANS; MALE; OXYGEN CONSUMPTION; QUESTIONNAIRES; SODIUM BICARBONATE; TIME FACTORS;

EID: 33749488924     PISSN: 01959131     EISSN: None     Source Type: Journal    
DOI: 10.1249/01.mss.0000230210.60957.67     Document Type: Article

References (49)

1. 2+ activation, contraction, and relaxation of frog skeletal muscle. Am. J. Physiol. 268:C55-C63, 1995.
2. BISHOP, D., J. EDGE, C. DAVIS, and C. GOODMAN. Induced metabolic alkalosis affects muscle metabolism and repeated-sprint ability. Med. Sci. Sports Exerc. 36:807-813, 2004.
3. CHASE, P., and M. J. KUSHMERICK. Effects of pH on contraction of rabbit fact and slow skeletal muscle fibers. Biophys. J. 53: 935-946, 1988.
4. 3. Int. J. Sports Med. 5:228-231, 1984.
5. 2+ activated force of skinned fibres from the soleus, cardiac, and adductor magnus muscles of rabbits. Pflugers Arch. 376:55-65, 1978.
6. EDGE, J., D. BISHOP, and C. GOODMAN. The effects of training intensity on muscle buffer capacity in females. Eur. J. Appl. Physiol. 5:1-9, 2005.
7. FATOUROS, I. G., S. TOURNIS, D. LEONTSINI, et al. Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J. Clin. Endocrinol. Metab. 900:5970-5977, 2005.
8. GAITANOS, G. C., M. E. NEVILL, S. BROOKS, and C. WILLIAMS. Repeated bouts of sprint running after induced alkalosis. J. Sports Sci. 9:355-369, 1991.
9. GLADDEN, L. Lactate uptake by skeletal muscle. Exerc. Sport Sci. Rev. 17:115-155, 1989.
10. GOLDFINCH, J., L. MCNAUGHTON, and P. DAVIES. Induced metabolic alkalosis and its effects on 400 m racing time. Eur. J. Appl. Physiol. 57:45-48, 1988.
11. GRANIER, P. L., H. DUBOUCHAUD, B. M. MERCIER, J. G. MERCIER, S. AHMADI, and C. H. PREFAUT. Effect of NaHCO3 on lactate kinetics in forearm muscles during leg exercise in man. Med. Sci. Sports Exerc. 28:692-697, 1996.
12. GREENHAFF, P. L., M. GLEESON, P. H. WHITING, and R. J. MAUGHAN. Dietary composition and acid base status: limiting factors in the performance of high intensity exercise. Eur. J. Appl. Physiol. 56:331-337, 1987.
13. HIRCHE, H., V. HOMBACH, H. D. LANGOHR, U. WACKER, and J. BUSSE. Lactic acid permeation rate in working gastrocnemii of dogs during metabolic alkalosis and acidosis. Pflugers Arch. 356:209-222, 1975.
14. HOLLIDGE-HORVAT, M. G., M. L. PAROLIN, D. WONG, N. L. JONES, and J. F. HEIGENHAUSER. Effect of induced metabolic alkalosis on human skeletal muscle metabolism during exercise. Am. J. Physiol. Endocrinol. Metab. 278:E316-E329, 2000.
15. i and lactic acid generation in exhaustive forearm exercise. Am. J. Physiol. Renal. Physiol. 255:F479-F485, 1988.
16. HORSWILL, C. A., D. L. COSTILL, W. J. FINK, et al. Influence of sodium bicarbonate on sprint performance: relationship to dosage. Med. Sci. Sports Exerc. 20:566-569, 1998.
17. INBAR, O., A. ROTSEIN, I. JACOBS, P. KAISER, R. DLIN, and R. DOTAN. The effect of alkaline treatment on short-term maximal exercise. J. Sport Sci. 12:95-104, 1983.
18. JACKSON, A. S., and M. L. POLLOCK. Generalized equations for predicting body density of man. Br. J. Nutr. 40:497-504, 1978.
19. JUEL, C. Intracellular pH recovery and lactate efflux in mouse soleus muscle stimulated in vitro: the involvement of sodium/ proton exchange and a lactate carrier. Acta Physiol. Scand. 132:363-371, 1988.
20. JUEL, C. Lactate-proton cotransport in skeletal muscle. Physiol. Rev. 77:321-358, 1997.
21. JUEL, C., S. KRISTIANSEN, H. PILEGAARD, J. WOJTASZEWSKI, and E. A. RICHTER. Kinetics of lactate transport in sarcolemmal giant vesicles obtained from human skeletal muscle. J. Appl. Physiol. 76:1031-1036, 1994.
22. LINDINGER, M. I., R. S. MCKELVIE, and G. J. HEIGENHAUSER. K+ and Lac- distribution in humans during and after high-intensity exercise: role in muscle fatigue attenuation? J. Appl. Physiol. 78:765-777, 1995.
23. LINDINGER, M. I., G. J. HEIGENHAUSER, and L. L. SPRIET. Effects of alkalosis on muscle ions at rest and with intense exercise. Can J. Physiol. Pharmacol. 68:820-829, 1990.
24. MAINWOOD, G. W., and P. WORSELEY-BROWN. The effect of extracellular pH and buffer concentration on the efflux of lactate from frog sartorius muscle. J. Physiol. 250:1-22, 1975.
25. MARX, J. O., S. E. GORDON, N. H. VOS, et al. Effect of alkalosis on plasma epinephrine responses to high intensity cycle exercise in humans. Eur. J. Appl. Physiol. 87:72-77, 2002.
26. MATSON, L. G., and Z. U. TRAN. Effect of sodium bicarbonate ingestion on anaerobic performance: a meta-analytic review. Int. J. Sports Nutr. 3:2-28, 1993.
27. MAUGHAN, R. J., and P. L. GREENHAFF. High intensity exercise performance and acid-base balance: the influence of diet and induced metabolic alkalosis. In: Advances in Nutrition and Top Sport, F. Brouns (Ed.). Basel, Switzerland: Karger, 1991, pp. 147-165.
28. MCCARTNEY, N., G. J. F. HEIGENHAUSER, and N. L. JONES. Effects of pH on maximal power output and fatigue during short-term dynamic exercise. J. Appl. Physiol. 55:225-229, 1983.
29. MCNAUGHTON, L., K. BACKX, G. PALMER, and N. STRANGE. Effects of chronic bicarbonate ingestion on the performance of high-intensity work. Eur. J. Appl. Physiol. 80:333-336, 1999.
30. MCNAUGHTON, L., N. STRANGE, and K. BACKX. The effects of chronic sodium bicarbonate ingestion on multiple bouts of anaerobic work and power output. J. Hum. Mov. Stud. 38: 307-322, 2000.
31. MCNAUGHTON, L., and T. THOMPSON. Acute versus chronic sodium bicarbonate ingestion and anaerobic work and power output. J. Sports Med. Phys. Fitness 41:456-462, 2001.
32. MCNAUGHTON, L. R. Bicarbonate ingestion: effects of dosage on 60 s cycle ergometry. J. Sports Sci. 10:415-423, 1992.
33. MCNAUGHTON, L. R., S. FORD, and C. NEWBOLD. Effect of sodium bicarbonate ingestion on high intensity exercise in moderately trained women. J. Strength Cond. Res. 11:98-102, 1997.
34. +: sarcoplasmic reticulum of skeletal and cardiac muscle. Biochem. Biophys. Res. Commun. 41: 830-836, 1970.
35. NIELSEN, O. B., F. DEPAOLI, and K. OVERGAARD. Protective effects of lactic acid on force production in rat skeletal muscle. J. Physiol. 536:161-166, 2001.
36. ROBERGS, R. A., F. FARZENAH, and D. PARKER. Biochemistry of exercise-induced metabolic acidosis. Am. J. Physiol. Regul. Integr. Comp. Physiol. 287:R502-R516, 2004.
37. ROTH, D. A. The sarcolemmal lactate transporter: transmembrane determinants of lactate flux. Med. Sci. Sports Exerc. 23: 925-934, 1991.
38. ROTH, D. A., and G. A. BROOKS. Lactate transport is mediated by a membrane-bound carrier in rat skeletal muscle sarcolemmal vesicles. Arch. Biochem. Biophys. 279:377-385, 1990.
39. SAKTALLA, A., M. PEREZ, M. MONTILLA, et al. Sodium bicarbonate ingestion does not alter the slow component of oxygen kinetics in professional cyclists. J. Sports Sci. 21:39-47, 2003.
40. SEJERSTED, O. M., and G. SJOGAARD. Dynamics and consequences of potassium shifts in skeletal muscle and heart during exercise. Physiol. Rev. 80:1411-1481, 2000.
41. SIRI, W. E. Gross composition of the body. In: Advances in biological and medical physics, J. H. Lawrence and C. A. Tobias (Eds.). New York: Academic Press, 1956, pp. 223-244.
42. SPRIET, L. L., C. G. MATSOS, S. J. PETERS, G. J. F. HEIGENHAUSER, and N. L. JONES. Effects of acidosis on rat muscle metabolism and performance during heavy exercise. Am. J. Physiol. 17:C337-C347, 1985.
43. STEPHENS, T. J., M. J. MCKENNA, B. J. CANNY, R. J. SNOW, and G. K. MCCONELL. Effect of sodium bicarbonate on muscle metabolism during intense endurance cycling. Med. Sci. Sports Exerc. 34:614-621, 2002.
44. STREET, D., J. NIELSEN, J. BANGSBO, and C. JUEL. Metabolic alkalosis reduces exercise-induced acidosis and potassium accumulation in human skeletal muscle interstitium. J. Physiol. 566: 481-489, 2005.
45. SUTTON, J. R., N. L. JONES, and C. J. TOEWS. Effects of alkalosis on skeletal muscle metabolism and performance during exercise. Clin. Sci. 61:331-338, 1981.
46. TIRYAKI, G. R., and H. A. ATTERBOM. The effects of sodium bicarbonate and sodium citrate on 600 m running time of trained females. J. Sports Med. 35:194-198, 1995.
47. VERBITSKY, O., J. MIZRAHI, M. LEVIN, and E. ISAKOV. Effect of ingested sodium bicarbonate on muscle force, fatigue and recovery. J. Appl. Physiol. 83:333-337, 1997.
48. WESTERBLAD, H., D. G. ALLEN, and J. LANNERGEN. Muscle fatigue: lactic acid or inorganic phosphate the major cause? News Physiol. Sci. 17:17-21, 2002.
49. WILKES, D., N. GLEDHILL, and R. SMYTH. Effect of acute induced metabolic alkalosis on 800 m racing time. Med. Sci. Sports Exerc. 15:277-280, 1983.