Novel Cu(II)-RGD-octapeptides: Synthesis, coordination mode, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and correlation of sequence with nano-structure

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 7, Issue 4, 2011, Pages 403-409

  Li, Ning ^a   Kang, Guifeng ^b   Gui, Lin ^b   Zhao, Ming ^b   Wang, Wenjing ^b   Zhang, Jianwei ^b   Yue, Yan Feng ^b   Peng, Shiqi ^a,b  

^a PEKING UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Cu(II) complexes; In vitro anti platelet aggregation; In vivo anti thrombotic activity; Nano feature; RGD octapeptides; TEM image

Indexed keywords

CU COMPLEXES; IN VIVO ANTI-THROMBOTIC ACTIVITY; IN-VITRO; NANO-FEATURE; RGD-OCTAPEPTIDES; TEM IMAGE;

NANOSTRUCTURES; PLATELETS; TRANSMISSION ELECTRON MICROSCOPY;

COORDINATION REACTIONS;

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; COPPER ARGINYLGLYCYLASPARAGINYLPHENELALANYLARGINYLGLYCYLASPARAGINYLPHENYLALANINE; COPPER ARGINYLGLYCYLASPARAGINYLSERYLARGINYLGLYCYLASPARAGINYLSERINE; COPPER ARGINYLGLYCYLASPARAGINYLVALYLARGINYLGLYCYLASPARAGINYLVALINE; CUPRIC ION; OCTAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; MALE; MASS SPECTROMETRY; NANOIMAGING; NONHUMAN; RAT; THROMBOCYTE AGGREGATION; THROMBOSIS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; COPPER; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; OLIGOPEPTIDES; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, WISTAR; THROMBOSIS;

EID: 79960737322     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.01.005     Document Type: Article

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