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Volumn 17, Issue 7-8, 2011, Pages 790-798

Widespread deregulation of phosphorylation-based signaling pathways in multiple myeloma cells:Opportunities for therapeutic intervention

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CD11B ANTIGEN; CD38 ANTIGEN; CD71 ANTIGEN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC GMP DEPENDENT PROTEIN KINASE; FOCAL ADHESION KINASE; HISTONE H1; HISTONE H2A; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN RECEPTOR; INTERLEUKIN 1; INTERLEUKIN 1BETA; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MYOSIN LIGHT CHAIN 2; PHOSPHOPROTEIN; PROTEOME; RAPAMYCIN; S6 KINASE; SOMATOMEDIN C RECEPTOR; SYNDECAN 1;

EID: 79960727977     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2011.00013     Document Type: Article
Times cited : (11)

References (40)
  • 2
    • 0042008128 scopus 로고    scopus 로고
    • Survival and proliferation factors of normal and malignant plasma cells
    • Klein B, et al. (2003) Survival and proliferation factors of normal and malignant plasma cells. Int. J. Hematol. 78:106-13.
    • (2003) Int. J. Hematol. , vol.78 , pp. 106-113
    • Klein, B.1
  • 4
    • 33745779502 scopus 로고    scopus 로고
    • The molecular classification of multiple myeloma
    • Zhan F, et al. (2006) The molecular classification of multiple myeloma. Blood. 108:2020-28.
    • (2006) Blood , vol.108 , pp. 2020-2028
    • Zhan, F.1
  • 5
    • 0036808580 scopus 로고    scopus 로고
    • Validated genomic approach to study differentially expressed genes in complex tissues
    • Wurmbach E, et al. (2002) Validated genomic approach to study differentially expressed genes in complex tissues. Neurochem. Res. 27:1027-33.
    • (2002) Neurochem. Res. , vol.27 , pp. 1027-1033
    • Wurmbach, E.1
  • 6
    • 2442617195 scopus 로고    scopus 로고
    • The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells
    • Tarte K, et al. (2004) The Bcl-2 family member Bfl-1/A1 is strongly repressed in normal and malignant plasma cells but is a potent anti-apoptotic factor for myeloma cells. Br. J. Haematol. 125:373-82.
    • (2004) Br. J. Haematol. , vol.125 , pp. 373-382
    • Tarte, K.1
  • 7
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. (2000) The hallmarks of cancer. Cell. 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 8
    • 65349156313 scopus 로고    scopus 로고
    • Kinome profiling using peptide arrays in eukaryotic cells
    • Parikh K, Peppelenbosch MP, Ritsema T. (2009) Kinome profiling using peptide arrays in eukaryotic cells. Methods Mol. Biol. 527:269-80.
    • (2009) Methods Mol. Biol. , vol.527 , pp. 269-280
    • Parikh, K.1    Peppelenbosch, M.P.2    Ritsema, T.3
  • 9
    • 33846254038 scopus 로고    scopus 로고
    • Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia
    • van Baal JW, et al. (2006) Comparison of kinome profiles of Barrett's esophagus with normal squamous esophagus and normal gastric cardia. Cancer Res. 66:11605-12.
    • (2006) Cancer Res , vol.66 , pp. 11605-11612
    • van Baal, J.W.1
  • 10
    • 34548039258 scopus 로고    scopus 로고
    • Profiling of the renal kinome: A novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage
    • de Borst MH, et al. (2006) Profiling of the renal kinome: A novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage. Am. J. Physiol. Renal. Physiol. 293:F428-37.
    • (2006) Am. J. Physiol. Renal. Physiol. , vol.293
    • de Borst, M.H.1
  • 11
    • 33745131127 scopus 로고    scopus 로고
    • Kinome analysis reveals nongenomic glucocorticoid receptordependent inhibition of insulin signaling
    • Lowenberg M, et al. (2006) Kinome analysis reveals nongenomic glucocorticoid receptordependent inhibition of insulin signaling. Endocrinology. 147:3555-62.
    • (2006) Endocrinology , vol.147 , pp. 3555-3562
    • Lowenberg, M.1
  • 12
    • 1642348370 scopus 로고    scopus 로고
    • Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma
    • Lin P, Owens R, Tricot G, Wilson CS. (2004) Flow cytometric immunophenotypic analysis of 306 cases of multiple myeloma. Am. J. Clin. Pathol. 121:482-88.
    • (2004) Am. J. Clin. Pathol. , vol.121 , pp. 482-488
    • Lin, P.1    Owens, R.2    Tricot, G.3    Wilson, C.S.4
  • 13
    • 66549106493 scopus 로고    scopus 로고
    • The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor
    • Sprynski AC, et al. (2009) The role of IGF-1 as a major growth factor for myeloma cell lines and the prognostic relevance of the expression of its receptor. Blood. 113:4614-26.
    • (2009) Blood , vol.113 , pp. 4614-4626
    • Sprynski, A.C.1
  • 14
    • 68149110019 scopus 로고    scopus 로고
    • The role of the insulin-like growth factor 1 receptor axis in multiple myeloma
    • Menu E, Van VE, Van CB, Vanderkerken K. (2009) The role of the insulin-like growth factor 1 receptor axis in multiple myeloma. Arch. Physiol. Biochem. 115:49-57.
    • (2009) Arch. Physiol. Biochem. , vol.115 , pp. 49-57
    • Menu, E.1    Van, V.E.2    Van, C.B.3    Vanderkerken, K.4
  • 15
    • 61449122079 scopus 로고    scopus 로고
    • Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component
    • Lust JA, et al. (2009) Induction of a chronic disease state in patients with smoldering or indolent multiple myeloma by targeting interleukin 1{beta}-induced interleukin 6 production and the myeloma proliferative component. Mayo Clin. Proc. 84:114-22.
    • (2009) Mayo Clin. Proc. , vol.84 , pp. 114-122
    • Lust, J.A.1
  • 16
    • 33644844811 scopus 로고    scopus 로고
    • Identification of two groups of smoldering multiple myeloma patients who are either high or low producers of interleukin-1
    • Xiong Y, et al. (2006) Identification of two groups of smoldering multiple myeloma patients who are either high or low producers of interleukin-1. J. Interferon. Cytokine Res. 26:83-95.
    • (2006) J. Interferon. Cytokine Res. , vol.26 , pp. 83-95
    • Xiong, Y.1
  • 17
    • 0026149834 scopus 로고
    • Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: Role of protein kinase C
    • Bomsztyk K, et al. (1991) Evidence that interleukin-1 and phorbol esters activate NF-kappa B by different pathways: role of protein kinase C. Cell. Regul. 2:329-35.
    • (1991) Cell. Regul. , vol.2 , pp. 329-335
    • Bomsztyk, K.1
  • 18
    • 77950818780 scopus 로고    scopus 로고
    • FAK activation is required for TNF-alpha-induced IL-6 production in myoblasts
    • Tseng WP, Su CM, Tang CH. (2010) FAK activation is required for TNF-alpha-induced IL-6 production in myoblasts. J. Cell. Physiol. 223:389-96.
    • (2010) J. Cell. Physiol. , vol.223 , pp. 389-396
    • Tseng, W.P.1    Su, C.M.2    Tang, C.H.3
  • 19
    • 0037342034 scopus 로고    scopus 로고
    • Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development
    • Saijo K, et al. (2003) Essential role of Src-family protein tyrosine kinases in NF-kappaB activation during B cell development. Nat. Immunol. 4:274-79.
    • (2003) Nat. Immunol. , vol.4 , pp. 274-279
    • Saijo, K.1
  • 20
    • 6344222902 scopus 로고    scopus 로고
    • The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells
    • Descamps G, et al. (2004) The magnitude of Akt/phosphatidylinositol 3'-kinase proliferating signaling is related to CD45 expression in human myeloma cells. J. Immunol. 173:4953-59.
    • (2004) J. Immunol. , vol.173 , pp. 4953-4959
    • Descamps, G.1
  • 21
    • 0142025123 scopus 로고    scopus 로고
    • Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway
    • Zhang J, Choi Y, Mavromatis B, Lichtenstein A, Li W. (2003) Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway. Oncogene. 22:6289-95.
    • (2003) Oncogene , vol.22 , pp. 6289-6295
    • Zhang, J.1    Choi, Y.2    Mavromatis, B.3    Lichtenstein, A.4    Li, W.5
  • 22
    • 30144433469 scopus 로고    scopus 로고
    • Analysis of PTEN deletions and mutations in multiple myeloma
    • Chang H, et al. (2006) Analysis of PTEN deletions and mutations in multiple myeloma. Leuk. Res. 30:262-65.
    • (2006) Leuk. Res. , vol.30 , pp. 262-265
    • Chang, H.1
  • 23
    • 0031021491 scopus 로고    scopus 로고
    • Cyclic GMPdependent protein kinase and cellular signaling in the nervous system
    • Wang X, Robinson PJ. (1997) Cyclic GMPdependent protein kinase and cellular signaling in the nervous system. J. Neurochem. 68:443-56.
    • (1997) J. Neurochem. , vol.68 , pp. 443-456
    • Wang, X.1    Robinson, P.J.2
  • 25
    • 7044234480 scopus 로고    scopus 로고
    • Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: Influence of nitric oxide and of insulin resistance
    • Doronzo G, et al. (2004) Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance. Eur. J. Clin. Invest. 34:664-73.
    • (2004) Eur. J. Clin. Invest. , vol.34 , pp. 664-673
    • Doronzo, G.1
  • 26
    • 77649305672 scopus 로고    scopus 로고
    • Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response
    • Pour L, et al. (2009) Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response. Ann. Hematol. 89:385-9.
    • (2009) Ann. Hematol. , vol.89 , pp. 385-389
    • Pour, L.1
  • 27
    • 0035571229 scopus 로고    scopus 로고
    • Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma
    • Mendes RV, Martins AR, de NG, Murad F, Soares FA. (2001) Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B-cell non-Hodgkin's lymphomas and multiple myeloma. Histopathology. 39:172-8.
    • (2001) Histopathology , vol.39 , pp. 172-178
    • Mendes, R.V.1    Martins, A.R.2    De, N.G.3    Murad, F.4    Soares, F.A.5
  • 28
    • 11244325899 scopus 로고    scopus 로고
    • Oxidant/antioxidant parameters and their relationship with medical treatment in multiple myeloma
    • Kuku I, et al. (2005) Oxidant/antioxidant parameters and their relationship with medical treatment in multiple myeloma. Cell. Biochem. Funct. 23:47-50.
    • (2005) Cell. Biochem. Funct. , vol.23 , pp. 47-50
    • Kuku, I.1
  • 29
    • 0037326481 scopus 로고    scopus 로고
    • A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model
    • Uneda S, et al. (2003) A nitric oxide synthase inhibitor, N(G)-nitro-l-arginine-methyl-ester, exerts potent antiangiogenic effects on plasmacytoma in a newly established multiple myeloma severe combined immunodeficient mouse model. Br. J. Haematol. 120:396-404.
    • (2003) Br. J. Haematol. , vol.120 , pp. 396-404
    • Uneda, S.1
  • 30
    • 0033828545 scopus 로고    scopus 로고
    • Mechanisms involved in the proand anti-apoptotic role of NO in human leukemia
    • Kolb JP. (2000) Mechanisms involved in the proand anti-apoptotic role of NO in human leukemia. Leukemia. 14:1685-94.
    • (2000) Leukemia , vol.14 , pp. 1685-1694
    • Kolb, J.P.1
  • 31
    • 33748913900 scopus 로고    scopus 로고
    • Beyond single-agent bortezomib: Combination regimens in relapsed multiple myeloma
    • Richardson PG, Mitsiades C, Ghobrial I, Anderson K. (2006) Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma. Curr. Opin. Oncol. 18:598-608.
    • (2006) Curr. Opin. Oncol. , vol.18 , pp. 598-608
    • Richardson, P.G.1    Mitsiades, C.2    Ghobrial, I.3    Anderson, K.4
  • 32
    • 38749084953 scopus 로고    scopus 로고
    • Bortezomib in combination with conventional chemotherapeutic agents for multiple myeloma compared with bortezomib alone
    • Min CK, et al. (2007) Bortezomib in combination with conventional chemotherapeutic agents for multiple myeloma compared with bortezomib alone. Jpn. J. Clin. Oncol. 37:961-8.
    • (2007) Jpn. J. Clin. Oncol. , vol.37 , pp. 961-968
    • Min, C.K.1
  • 33
    • 66149146607 scopus 로고    scopus 로고
    • Bortezomib: A review of its use in patients with multiple myeloma
    • Curran MP, McKeage K. (2009) Bortezomib: a review of its use in patients with multiple myeloma. Drugs. 69:859-88.
    • (2009) Drugs , vol.69 , pp. 859-888
    • Curran, M.P.1    McKeage, K.2
  • 34
    • 41949099660 scopus 로고    scopus 로고
    • Alkylating agents induce activation of NFkappaB in multiple myeloma cells
    • Baumann P, Mandl-Weber S, Oduncu F, Schmidmaier R. (2008) Alkylating agents induce activation of NFkappaB in multiple myeloma cells. Leuk. Res. 32:1144-7.
    • (2008) Leuk. Res. , vol.32 , pp. 1144-1147
    • Baumann, P.1    Mandl-Weber, S.2    Oduncu, F.3    Schmidmaier, R.4
  • 35
    • 0030864876 scopus 로고    scopus 로고
    • Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism
    • Chauhan D, et al. (1997) Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Oncogene. 15:837-43.
    • (1997) Oncogene , vol.15 , pp. 837-843
    • Chauhan, D.1
  • 36
    • 17444440115 scopus 로고    scopus 로고
    • Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone
    • Stromberg T, et al. (2004) Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 103:3138-47.
    • (2004) Blood , vol.103 , pp. 3138-3147
    • Stromberg, T.1
  • 37
    • 33644516582 scopus 로고    scopus 로고
    • Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
    • Yan H, et al. (2006) Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer Res. 66:2305-13.
    • (2006) Cancer Res , vol.66 , pp. 2305-2313
    • Yan, H.1
  • 38
    • 58149481284 scopus 로고    scopus 로고
    • The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
    • Baumann P, Mandl-Weber S, Oduncu F, Schmidmaier R. (2009) The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma. Exp. Cell Res. 315:485-97.
    • (2009) Exp. Cell Res. , vol.315 , pp. 485-497
    • Baumann, P.1    Mandl-Weber, S.2    Oduncu, F.3    Schmidmaier, R.4
  • 39
    • 72149090432 scopus 로고    scopus 로고
    • Evaluating temsirolimus activity in multiple tumors: A review of clinical trials
    • Suppl
    • Dancey JE, Curiel R, Purvis J. (2009) Evaluating temsirolimus activity in multiple tumors: a review of clinical trials. Semin. Oncol. 36(Suppl 3):S46-58.
    • (2009) Semin. Oncol. , vol.36 , Issue.3
    • Dancey, J.E.1    Curiel, R.2    Purvis, J.3
  • 40
    • 43749103335 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral, smallmolecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers
    • Adjei AA, et al. (2008) Phase I pharmacokinetic and pharmacodynamic study of the oral, smallmolecule mitogen-activated protein kinase kinase 1/2 inhibitor AZD6244 (ARRY-142886) in patients with advanced cancers. J. Clin. Oncol. 26:2139-46.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 2139-2146
    • Adjei, A.A.1


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