Pathway analysis of gene expression in local lymph nodes draining skin exposed to three different sensitizers

Journal of Applied Toxicology

Volumn 31, Issue 5, 2011, Pages 455-462

  Ku, Hyun Ok ^a   Jeong, Sang Hee ^b   Kang, Hwan Goo ^a   Son, Seong Wan ^a   Yun, So mi ^a   Ryu, Doug Young ^c  

^a Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

^b Hoseo University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

1 chloro 2,4 dinitrobenzene; 2 phenyl 4 ethoxymethylene 5 oxazolone; Gene expression; Pathway; Skin sensitization; Toluene 2, 4 diisocyanate

Indexed keywords

CYTOKINE;

ARTICLE; CELL CYCLE; CELL GROWTH; DNA REPLICATION; GENE EXPRESSION; GENETIC IDENTIFICATION; GENOME ANALYSIS; IMMUNE RESPONSE; LYMPH NODE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PYRIMIDINE METABOLISM; REAL TIME POLYMERASE CHAIN REACTION; SKIN SENSITIZATION; UNINDEXED SEQUENCE; UPREGULATION;

ADMINISTRATION, TOPICAL; ALLERGENS; ANIMALS; CROTON OIL; DINITROCHLOROBENZENE; GENE EXPRESSION; GENOMICS; LOCAL LYMPH NODE ASSAY; LYMPH NODES; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXAZOLONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOLUENE 2,4-DIISOCYANATE;

EID: 79960722216     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1646     Document Type: Article

References (29)

1. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate - a practical and powerful approach to multiple testing. J. R. Stat. Soc., B Met. 57: 289-300.
2. Boussiquet-Leroux C, Durand-Cavagna G, Herlin K, Holder D. 1995. Evaluation of lymphocyte proliferation by immunohistochemistry in the local lymph node assay. J. Appl. Toxicol. 15: 465-475.
3. Boverhof DR, Gollapudi BB, Hotchkiss JA, Osterloh-Quiroz M, Woolhiser MR. 2009. Evaluation of a toxicogenomic approach to the local lymph node assay (LLNA). Toxicol. Sci. 107: 427-439.
4. Crandall H, Dunn DM, Ma Y, Wooten RM, Zachary JF, Weis JH, Weiss RB, Weis JJ. 2006. Gene expression profiling reveals unique pathways associated with differential severity of lyme arthritis. J. Immunol. 177: 7930-7942.
5. Ehling G, Hecht M, Heusener A, Huesler J, Gamer AO, van Loveren H, Maurer T, Riecke K, Ullmann L, Ulrich P, Vandebriel R, Vohr HW. 2005a. An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: first round. Toxicology 212: 60-68.
6. Ehling G, Hecht M, Heusener A, Huesler J, Gamer AO, van Loveren H, Maurer T, Riecke K, Ullmann L, Ulrich P, Vandebriel R, Vohr HW. 2005b. An European inter-laboratory validation of alternative endpoints of the murine local lymph node assay: 2nd round. Toxicology 212: 69-79.
7. Fernandez TD, Mayorga C, Torres MJ, Cornejo-Garcia JA, López S, Chaves P, Rondon C, Blanca M. 2008. Cytokine and chemokine expression in the skin from patients with maculopapular exanthema to drugs. Allergy 63: 712-719.
8. Flier J, Boorsma DM, van Bee PJ, Nieboer C, Stoof TJ, Willemze R, Tensen CP. 2001. Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. J. Pathol. 194: 398-405.
9. Gunn MD, Tangemann K, Tam C, Cyster JG, Rosen SD, Williams LT. 1998. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naïve T lymphocytes. Proc. Natl Acad. Sci. USA 95: 258-263.
10. Hartmann B, Staedtler F, Hartmann N, Meingassner J, Firat H. 2006. Gene expression profiling of skin and draining lymph nodes of rats affected with cutaneous contact hypersensitivity. Inflamm. Res. 55: 322-334.
11. He B, Munsron AE, Meade BJ. 2001. Analysis of gene expression induced by irritant and sensitizing chemicals using oligonucleotide arrays. Int. Immunopharmacol. 1: 867-879.
12. Homey B, Schilling C, Blümel J, Schuppe HC, Ruzicka T, Ahr HJ, Lehmann P, Vohr HW. 1998. An integrated model for the differentiation of chemical-induced allergic and irritant skin reactions. Toxicol. Appl. Pharmacol. 153: 83-94.
13. Hosack DA, Dennis G Jr, Sherman BT, Lane HC, Lempicki RA. 2003. Identifying biological themes within lists of genes with EASE. Genome Biol. 4:R70.
14. ICCVAM. 2001. ICCVAM immunotoxicology working group recommended protocol for the murine local lympn node assay (LLNA): testing of chemicals for contact sensitizing (allergic contact dermatitis [ACD]) potential; 1-12.
15. Kimber I, Weisenberger C. 1989. A murine local lymph node assay for the identification of contact allergens. Assay development and results of an initial validation study. Arch. Toxicol. 63: 274-282.
16. Klink KJ, Meade BJ. 2003. Dermal exposure to 3-amino-5-mercapto-1, 2, 4-triazole (AMT) induces sensitization and airway hyperreactivity in BALB/c mice. Toxicol. Sci. 75: 89-98.
17. Kota RS, Rutledge JC, Gohil K, Kumar A, Enelow RI, Ramana CV. 2006. Regulation of gene expression in RAW 264.7 macrophage cell line by interferon-gamma. Biochem. Biophys. Res. Commun. 342: 1137-1146.
18. Ku HO, Jeong SH, Kang HG, Pyo HM, Cho JH, Son SW, Ryu DY. 2008a. Analysis of differential gene expression in auricular lymph nodes draining skin exposed to sensitizers and irritants. Toxicol. Lett. 177: 1-9.
19. Ku HO, Jeong SH, Kang HG, Pyo HM, Cho JH, Son SW, Kim HR, Lee KJ, Ryu DY. 2008b. Intracellular expression of cytokines and granzyme B in auricular lymph nodes draining skin exposed to irritants and sensitizers. Toxicology 250: 116-123.
20. Ku HO, Jeong SH, Kang HG, Pyo HM, Cho JH, Son SW, Yun SM, Ryu DY. 2009. Gene expression profiles and pathways in skin inflammation induced by three different sensitizers and an irritant. Toxicol. Lett. 190: 231-237.
21. Meller S, Lauerma AI, Kopp FM, Winterberg F, Anthoni M, Müller A, Gombert M, Haahtela A, Alenius H, Rieker J, Dieu-Nosjean MC, Kubitza RC, Gleichmann E, Ruzicka T, Zlotnik A, Homey B. 2007. Chemokine responses distinguish chemical-induced allergic from irritant skin inflammation: memory T cells make the difference. Allergy Clin. Immunol. 119: 1470-1480.
22. Mori T, Kabashima K, Yoshiki R, Sugita K, Shiraishi N, Onoue A, Kuroda E, Kobayashi M, Yamashita U, Tokura Y. 2008. Cutaneous hypersensitivities to hapten are controlled by IFN-gamma-upregulated keratinocyte Th1 chemokines and IFN-gamma-downregulated langerhans cell Th2 chemokines. J. Invest. Dermatol. 128: 1719-1727.
23. OECD. 2002. Guidelines for Testing of Chemicals no. 429. Skin Sensitisation: Local Lymph Node Assay.
24. Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA. 1995. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle. Proc. Natl Acad. Sci. USA 92: 2403-2407.
25. Suda A, Yamashita M, Tabei M, Taguchi K, Vohr H-W, Tsutsui N, Suzuki R, Kikuchi K, Sakaguchi K, Mochizuki K, Nakamura K. 2002. Local lymph node assay with non-radioisotope alternative endpoints. J. Toxicol. Sci. 27: 205-218.
26. Takeyoshi M, Yamasaki K, Yakabe Y, Takatsuki M, Kimber I. 2001. Development of non-radio isotopic endpoint of murine local lymph node assay based on 5-bromo-2'-deoxyuridine (BrdU) incorporation. Toxicol. Lett. 119: 203-208.
27. Ustrell V, Hoffman L, Pratt G, Rechsteiner M. 2002. PA200, a nuclear proteasome activator involved in DNA repair. EMBO J. 21: 3516-3525.
28. Vandebriel RJ, De Jong WH, Hendriks JJ, Van Loveren H. 2003. Impact of exposure duration by low molecular weight compounds on interferon-gamma and interleukin-4 mRNA expression and production in the draining lymph nodes of mice. Toxicology 188: 1-13.
29. Vohr H-W, Blümel J, Blotz A, Homey B, Ahr HJ. 2000. An intra-laboratory validation of the Integrated Model for the Differentiation of Skin Reactions (IMDS): discrimination between (photo)allergic and (photo)irritant skin reactions in mice. Arch. Toxicol. 73: 501-509.