Age-related changes in human trabecular bone: Relationship between microstructural stress and strain and damage morphology

Journal of Biomechanics

Volumn 44, Issue 12, 2011, Pages 2279-2285

  Green, Jessica O ^a,b   Nagaraja, Srinidhi ^a,c   Diab, Tamim ^a   Vidakovic, Brani ^d   Guldberg, Robert E ^a,d  

^a GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c CENTER FOR DEVICES AND RADIOLOGICAL HEALTH   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Aging; Biomechanics; Finite element analysis; Microcomputed tomography; Microdamage; Trabecular bone

Indexed keywords

AGE-RELATED; AGE-RELATED CHANGES; BONE ARCHITECTURE; BONE MATRIX; DAMAGE ASSESSMENTS; DAMAGE INITIATION; DAMAGE MORPHOLOGY; HUMAN TRABECULAR BONE; LINEAR FINITE ELEMENTS; LOADING AXIS; MICRO-ARCHITECTURAL ANALYSIS; MICRO-DAMAGE; MICRO-STRUCTURAL; MICROCOMPUTED TOMOGRAPHY; OSTEOPOROTIC FRACTURES; PRINCIPAL STRESS; SKELETAL FRAGILITY; STRESS AND STRAIN; TRABECULAR BONES; VON MISES; VON MISES STRESS;

BIOMECHANICS; BONE; COMPUTERIZED TOMOGRAPHY; ELASTICITY; FINITE ELEMENT METHOD; FRACTURE; MORPHOLOGY; STRAIN; STRUCTURAL DESIGN; TISSUE;

DAMAGE DETECTION;

ADULT; AGED; AGING; ARTICLE; BIOMECHANICS; BONE DEFECT; BONE DENSITY; BONE MICRODAMAGE; BONE MINERALIZATION; BONE STRESS; BONE STRUCTURE; CADAVER; CONTROLLED STUDY; FEMALE; FEMUR; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN TISSUE; MECHANICAL STRESS; MICRO-COMPUTED TOMOGRAPHY; MICROSTRUCTURAL STRESS; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; TRABECULAR BONE;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; BIOMECHANICS; BONE AND BONES; FEMALE; FEMORAL FRACTURES; FEMUR; FINITE ELEMENT ANALYSIS; HUMANS; MODELS, STATISTICAL; OSTEOPOROSIS; STRESS, MECHANICAL; X-RAY MICROTOMOGRAPHY;

EID: 79960714052     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.05.034     Document Type: Article

References (32)

1. Arthur Moore T.L., Gibson L.J. Microdamage accumulation in bovine trabecular bone in uniaxial compression. J. Biomech. Eng. 2002, 124(1):63-71.
2. Boskey A., Mendelsohn R. Infrared analysis of bone in health and disease. J. Biomed. Opt. 2005, 10(3):031102.
3. Burr D.B., Allen M.R. Low bone turnover and microdamage? How and where to assess it?. J. Bone. Miner. Res. 2008, 23(7):1150-1151. (author reply 1152-3).
4. Burr D.B., Forwood M.R., et al. Bone microdamage and skeletal fragility in osteoporotic and stress fractures. J. Bone Miner. Res. 1997, 12(1):6-15.
5. Burr D.B., Stafford T. Validity of the bulk staining technique to seperate artifactual from in vivo bone microdamage. Clin. Orthop. Relat. Res. 1990, 260. (305-208).
6. Busse B., Hahn M., et al. Increased calcium content and inhomogeneity of mineralization render bone toughness in osteoporosis: mineralization, morphology and biomechanics of human single trabeculae. Bone 2009, 45(6):1034-1043.
7. Fazzalari N.L., Forwood M.R., et al. Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 1998, 22(4):381-388.
8. Fazzalari N.L., Kuliwaba J.S., et al. Cancellous bone microdamage in the proximal femur: influence of age and osteoarthritis on damage morphology and regional distribution. Bone 2002, 31(6):697-702.
9. Fyhrie D.P., Hoshaw S.J., et al. Shear stress distribution in the trabeculae of human vertebral bone. Ann. Biomed. Eng. 2000, 28(10):1194-1199.
10. Guldberg R.E., Hollister S.J., et al. The accuracy of digital image-based finite element models. J. Biomech. Eng. 1998, 120(2):289-295.
11. Hildebrand T., Laib A., et al. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J. Bone Miner. Res. 1999, 14(7):1167-1174.
12. Huja S.S., Hasan M.S., et al. Development of a fluorescent light technique for evaluating microdamage in bone subjected to fatigue loading. J. Biomech. 1999, 32(11):1243-1249.
13. Keaveny T.M., Pinilla T.P., et al. Systematic and random errors in compression testing of trabecular bone. J. Orthop. Res. 1997, 15(1):101-110.
14. Keaveny T.M., Wachtel E.F., et al. Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus. J. Biomech. 1994, 27(9):1137-1146.
15. Kimmel D.B., Recker R.R., et al. A comparison of iliac bone histomorphometric data in post-menopausal osteoporotic and normal subjects. Bone Miner. 1990, 11(2):217-235.
16. Lee T.C., Mohsin S., et al. Detecting microdamage in bone. J. Anat. 2003, 203(2):161-172.
17. Linde F., Sorensen H.C. The effect of different storage methods on the mechanical properties of trabecular bone. J. Biomech. 1993, 26(10):1249-1252.
18. McNamara L.M., Prendergast P.J. Perforation of cancellous bone trabeculae by damage-stimulated remodelling at resorption pits: a computational analysis. Eur. J. Morphol. 2005, 42(1-2):99-109.
19. Mori S., Harruff R., et al. Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 1997, 21(6):521-526.
20. Nagaraja S., Lin A.S., et al. Age-related changes in trabecular bone microdamage initiation. Bone 2007, 40(4):973-980.
21. O'Brien F.J., Taylor D., et al. An improved labelling technique for monitoring microcrack growth in compact bone. J. Biomech. 2002, 35(4):523-526.
22. O'Neal J.M., Diab T., et al. One year of alendronate treatment lowers microstructural stresses associated with trabecular microdamage initiation. Bone 2010, 47(2):241-247.
23. Parfitt A.M., Mathews C.H., et al. Relationships between surface, volume, and thickness of iliac trabecular bone in aging and in osteoporosis. Implications for the microanatomic and cellular mechanisms of bone loss. J. Clin. Invest. 1983, 72(4):1396-1409.
24. Paschalis E.P., Betts F., et al. FTIR microspectroscopic analysis of normal human cortical and trabecular bone. Calcif. Tissue Int. 1997, 61(6):480-486.
25. Paschalis E.P., Shane E., et al. Bone fragility and collagen cross-links. J. Bone Miner. Res. 2004, 19(12):2000-2004.
26. Recker R., Lappe J., et al. Bone remodeling increases substantially in the years after menopause and remains increased in older osteoporosis patients. J. Bone Miner. Res. 2004, 19(10):1628-1633.
27. Schaffler M.B., Choi K., et al. Aging and matrix microdamage accumulation in human compact bone. Bone 1995, 17(6):521-525.
28. van Rietbergen B., Weinans H., et al. Computational strategies for iterative solutions of large FEM spplications employing voxel data. Int. J. Numer. Methods Eng. 1996, 39:2743-2767.
29. van Rietbergen B., Weinans H., et al. A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J. Biomech. 1995, 28(1):69-81.
30. van Ruijven L.J., Mulder L., et al. Variations in mineralization affect the stress and strain distributions in cortical and trabecular bone. J. Biomech. 2007, 40(6):1211-1218.
31. Yeni Y.N., Hou F.J., et al. Trabecular shear stresses predict in vivo linear microcrack density but not diffuse damage in human vertebral cancellous bone. Ann. Biomed. Eng. 2003, 31(6):726-732.
32. Yeni Y.N., Zelman E.A., et al. Trabecular shear stress amplification and variability in human vertebral cancellous bone: relationship with age, gender, spine level and trabecular architecture. Bone 2008, 42(3):591-596.