Preparation and in vitro evaluation of pH-sensitive TAT peptide conjugated micelles

Yaoxue Xuebao

Volumn 46, Issue 5, 2011, Pages 599-604

  Chen, Wei ^a   Jin, Ming Ji ^a   Gao, Zhong Gao ^a   Wang, Li Ping ^a   Piao, Hai Feng ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cell penetrating protein; Doxorubicin; pH sensitive; Polymer micelle

Indexed keywords

2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; DOXORUBICIN; GLYCEROPHOSPHOETHANOLAMINE; MACROGOL; METHOXY(POLYETHYLENE GLYCOL) 200 1; PEPTIDE; TRANSACTIVATOR OF TRANSCRIPTION PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; IN VITRO STUDY; PH MEASUREMENT; TUMOR CELL;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL-PENETRATING PEPTIDES; DOXORUBICIN; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; FEMALE; GENE PRODUCTS, TAT; HYDROGEN-ION CONCENTRATION; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICELLES; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; SULFADIAZINE;

EID: 79960711884     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Rudolph C, Plank C, Lausier J, et al. Oligomers of the arginine-rich motif of the HIV-1 TAT protein are capable of transferring plasmid DNA into cells [J]. J Biol Chem, 2003, 278: 11411-11418. (Pubitemid 36792699)
2. Torchilin VP, Levchenko TS. TAT-liposomes: a novel intracellular drug carrier [J]. Curr Protein Pept Sci, 2003, 4: 133-140. (Pubitemid 36834012)
3. Yamagata M, Hasuda K, Stamato T, et al. The contribution of lactic acid to acidification of tumors: studies of variant cells lacking lactate dehydrogenase [J]. Br J Cancer, 1998, 77: 1726-1731. (Pubitemid 28254604)
4. Xu JX, Tang JB, Zhao LH, et al. Advances in the study of tumor pH-responsive polymeric micelles for cancer drug targeting delivery [J]. Acta Pharm Sin, 2009, 44: 1328-1335.
5. Engin K, Leeper DB, Cater JR, et al. Extracellular pH distribution in human tumors [J]. Int J Hyperthermia, 1995, 11: 211-216.
6. Sethuraman VA, Bae YH. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors [J]. J Control Release, 2007, 118: 216-224. (Pubitemid 46350711)
7. Lee ES, Na K, Bae YH. Doxorubicin loaded pH-sensitive polymeric micelles for reversal of resistant MCF-7 tumor [J]. J Control Release, 2005, 103: 405-418. (Pubitemid 40342538)
8. Zhao W, Ma HL, Qi XR. Cationic liposomes loaded with doxorubicin targeting to the tumor neovasculature in vitro [J]. Acta Pharm Sin, 2007, 42: 982-988.
9. Xu XY, Zhou JP, Li L, et al. Preparation of doxorubicin-loaded chitosan polymeric micelle and study on its tissue biodistribution in mice [J]. Acta Pharm Sin, 2008, 43: 743-748.
10. Tang N, Du G, Wang N, et al. Improving penetration in tumors with nanoassemblies of phospholipids and doxorubicin [J]. J Natl Cancer Inst, 2007, 99: 1004-1015. (Pubitemid 47232602)
11. Lee JY, Choi YS, Suh JS, et al. Cell-penetrating chitosan/ doxorubicin/TAT conjugates for efficient cancer therapy [J]. Int J Cancer, 2010, 128: 2470-2480.
12. Torchilin VP, Levchenko TS, Lukyanov AN, et al. p-Nitrophenylcarbonyl- PEG-PE-liposomes: fast and simple attachment of specific ligands, including monoclonal antibodies, to distal ends of PEG chains via p-nitrophenylcarbonyl groups [J]. Biochim Biophys Acta, 2001, 1511: 397-411.
13. Wang W, Tang N, Zhang CL, et al. Cell penetrating peptides enhance intracellular translocation and function of siRNA encapsulated in pegylated liposomes [J]. Acta Pharm Sin, 2006, 41: 142-148. (Pubitemid 43516132)