Preparation of doxorubicin-loaded chitosan polymeric micelle and study on its tissue biodistribution in mice

Yaoxue Xuebao

Volumn 43, Issue 7, 2008, Pages 743-748

  Xu, Xiang Yang ^a,b   Zhou, Jian Ping ^b   Li, Ling ^a,b   Zhang, Yong ^b   Huo, Mei Rong ^b   Wang, Xing ^b   Lü, Lin ^b  

^a Jiangsu Simcere Pharmaceutical R and D Co Ltd   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Chitosan polymeric micelle; Doxorubicin; Targeting; Tissue biodistribution

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; CHITOSAN; DOXORUBICIN; DRUG CARRIER; DRUG DERIVATIVE; POLYMER;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; CHEMISTRY; DRUG DELIVERY SYSTEM; FEMALE; LIVER; MALE; METABOLISM; MICELLE; MOUSE; PARTICLE SIZE; SPLEEN; TISSUE DISTRIBUTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AREA UNDER CURVE; CHITOSAN; DOXORUBICIN; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FEMALE; LIVER; MALE; MICE; MICELLES; PARTICLE SIZE; POLYMERS; SPLEEN; TISSUE DISTRIBUTION;

EID: 50549092049     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Park JH, Kwon S, Nam JO, et al. Self-assembled nanopaticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery [J]. J Control Release, 2004,95:579-588.
2. Gao ZG, Lee DH, Kim DI, et al. Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice [J]. J Drug Target, 2005,13:391-397.
3. Marin A, Sun H, Husseini G, et al. Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake [J]. J Control Release, 2002,84:39-47.
4. Yoo HS, Park TG. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer [J]. J Control Release, 2001,70:63-70.
5. Yoo HS, Park TG. Folate receptor targeted biodegradable polymeric doxorubicin micelles [J]. J Control Release, 2004,96:273-283.
6. Wang CH, Wang CH, Hsiue GH. Polymeric micelles with a pH-responsive structure as intracellular drug carriers [J]. J Control Release, 2005,108:140-149.
7. Xu XY, Li L, Yin XJ, et al. Preparation and characterization of N-octyl-N′-succinyl chitosan as a tumour targeting carrier [J]. J China Pharm Univ, 2007,38:17-20.
8. Huh KM, Lee SC, Cho YW, et al. Hydrotropic polymer micelle system for delivery of paditaxel [J]. J Control Release, 2005,101:59-68.
9. Cheon Lee S, Kim C, Chan Kwon I, et al. Polymeric micelles of poly (2-ethyl-2-oxazoline)-block-poly (epsilon-caprolactone) copolymer as a carrier for paclitaxel [J]. J Control Release, 2003,89:437-446.
10. Rapoport N, Pitt WG, Sun H, et al. Drug delivery in polymeric micelles: from in vitro to in vivo [J]. J Control Release, 2003,91:85-95.
11. Hyung Park J, Kwon S, Lee M, et al. Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity [J]. Biomaterials, 2006,27:119-126.
12. Huo MR, Zhou JP, Wei Y, et al. Preparation of paclitaxel-loaded chitosan polymeric micelles and influence of surface charges on their tissue biodistribution in mice [J]. Acta Pharm Sin, 2006,41: 867-872.