Genetical genomics of Th1 and Th2 immune response in a baboon model of atherosclerosis risk factors

Atherosclerosis

Volumn 217, Issue 2, 2011, Pages 387-394

  Vinson, A ^a,b   Curran, J E ^c   Johnson, M P ^c   Dyer, T D ^c   Moses, E K ^c   Blangero, J ^c   Cox, L A ^c,d   Rogers, J ^d,e   Havill, L M ^c   VandeBerg, J L ^c,d   Mahaney, M C ^c,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^d SOUTHWEST NATIONAL PRIMATE RESEARCH CENTER   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Atherosclerosis; Baboon; Gene expression; Inflammation; QTL; Th1; Th2

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD69 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR3; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND; GAMMA INTERFERON RECEPTOR; GAMMA INTERFERON RECEPTOR 1; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR BETA; INTERLEUKIN 12 RECEPTOR BETA1; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 4 RECEPTOR; LAT PROTEIN; LYMPHOTOXIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN KINASE FYN; PROTEIN TYROSINE PHOSPHATASE SHP 2; STAT1 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR NFAT3; UNINDEXED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ATHEROSCLEROSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC RISK; GENETIC TRANSCRIPTION; GENOME; HERITABILITY; LINKAGE ANALYSIS; MALE; MAXIMUM LIKELIHOOD METHOD; NONHUMAN; PAPIO HAMADRYAS; PEDIGREE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RISK FACTOR; TH1 CELL; TH2 CELL;

ANIMALS; ATHEROSCLEROSIS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GENETIC PLEIOTROPY; GENETIC PREDISPOSITION TO DISEASE; HEREDITY; INFLAMMATION; MALE; MODELS, GENETIC; PAPIO HAMADRYAS; PHENOTYPE; QUANTITATIVE TRAIT LOCI; RISK ASSESSMENT; RISK FACTORS; TH1 CELLS; TH2 CELLS; TRANSCRIPTION, GENETIC;

EID: 79960699625     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.06.015     Document Type: Article

References (38)

1. Hansson G.K., Robertson A.-K., Soderberg-Naucler C. Inflammation and atherosclerosis. Annu. Rev. Pathol. Mech. Dis. 2006, 1:297-329.
2. Hosono M., de Boer O.J., van der Wal A.C., van der Loos C.M., Teeling P., Piek J.J., et al. Increased expression of T cell activation markers (CD25, CD26, CD40L and CD69) in atherectomy specimens of patients with unstable angina and acute myocardial infarction. Atherosclerosis 2003, 168:73-80.
3. Hansson G.K., Holm J., Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am. J. Pathol. 1989, 135:169-175.
4. Methe H., Brunner S., Wiegand D., Nabauer M., Koglin J., Edelman E.R. Enhanced T-helper-1 lymphocyte activation patterns in acute coronary syndromes. J. Am. Coll. Cardiol. 2005, 45:1939-1945.
5. Liuzzo G., Kopecky S.L., Frye R.L., O'Fallon M., Maseri A., Goronzy J.J., et al. Perturbation of the T-cell repertoire in patients with unstable angina. Circulation 1999, 100:2135-2139.
6. Szodoray P., Timar O., Veres K., Der H., Szomjak E., Lakos G., et al. Th1/Th2 imbalance, measured by circulating and intracytoplasmic inflammatory cytokines-immunological alterations in acute coronary syndrome and stable coronary artery disease. Scand. J. Immunol. 2006, 64:336-344.
7. Huber S.A., Sakkinen P., David C., Newell M.K., Tracy R.P. T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia. Circulation 2001, 103:2610-2616.
8. Gerdes N., Sukhova G.K., Libby P., Reynolds R.S., Young J.L., Schonbeck U. Expression of interleukin (IL)-18 and functional IL-18 receptor on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for atherogenesis. J. Exp. Med. 2002, 195:245-257.
9. Seder R.A. High-dose IL-2 and IL-15 enhance the in vitro priming of naïve CD4+ T cells for IFN-γ but have differential effects on priming for IL-4. J. Immunol. 1996, 156:2413-2422.
10. Hansson G.K., Jonasson L., Holm H., Claesson-Welsh L., Class II MHC antigen expression in the atherosclerotic plaque: smooth muscle cells express HLA-DR, HLA-DQ and the invariant gamma chain. Clin. Exp. Immunol. 1986, 64:261-268.
11. Schreyer S.A., Vick C.M., LeBoeuf R.C. Loss of lymphotoxin-alpha but not tumor necrosis factor-alpha reduces atherosclerosis in mice. J. Biol. Chem. 2002, 277:12364-12368.
12. Hansson G.K., Jonasson L., Lojsthed B., Stemme S., Kocher O., Gabbiani G. Localization of T lymphocytes and macrophages in fibrous and complicated human atherosclerotic plaques. Atherosclerosis 1988, 72:135-141.
13. Jonasson L., Holm J., Skalli O., Bondjers G., Hansson G.K. Regional accumulation of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis 1986, 6:131-138.
14. van der Wal A.C., Becker A.E., van der Loos C.M., Das P.K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 1994, 89:36-44.
15. Ovchinnikova O., Robertson A.K.L., Wagsater D., Folco E.J., Hyry M., Myllyharju J., et al. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of ApoE-/- mice. Am. J. Pathol. 2009, 174:693-700.
16. Benagiano M., Azzurri A., Cievo A., Amedei A., Tamburini C., Ferrari M., et al. T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc. Natl. Acad. Sci. USA 2003, 100:6658-6663.
17. Frostegard J., Ulfgren A.K., Nyberg P., Hedin U., Swedenborg J., Andersson U., et al. Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines. Atherosclerosis 1999, 145:33-43.
18. Laurat E., Poirier B., Tupin E., Caligiuri G., Hansson G.K., Bariety J., et al. In vivo downregulation of T helper cell 1 immune responses reduces atherogenesis in apolipoprotein E-knockout mice. Circulation 2001, 104:197-202.
19. Uyemura K., Demer L.L., Castle S.C., Jullien D., Berliner J.A., Gately M.K., et al. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J. Clin. Invest. 1996, 97:2130-2138.
20. Lee T.S., Yen H.C., Pan C.C., Chau L.Y. The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice. Arterioscler. Thromb. Vasc. Biol. 1999, 19:734-742.
21. Yamaoka-Tojo M., Tojo T., Inomata T., Machida Y., Osada K., Izumi T. Circulating levels of interleukin 18 reflect etiologies of heart failure: Th1/Th2 cytokine imbalance exaggerates the pathophysiology of advanced heart failure. J. Card. Fail. 2002, 8:21-27.
22. Agnello D., Lankford C.S., Bream J., Jorinobu A., Gadina M., O'Shea J.J., et al. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J. Clin. Immunol. 2003, 23:147-161.
23. Spellberg B., Edwards J.E. Type 1/Type 2 immunity in infectious diseases. Clin. Infect. Dis. 2001, 32:76-102.
24. Pinderski L.J., Fischbein M.P., Subbanagounder G., Fishbein M.C., Kubo N., Cheroutre H., et al. Overexpression of interleukin-10 by activated T lymphocytes inhibits atherosclerosis in LDL receptor-deficient mice by altering lymphocyte and macrophage phenotypes. Circ. Res. 2002, 90:1064-1071.
25. Binder C.J., Hartvigsen K., Chang M.K., Miller M., Broide D., Palinski W., et al. IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J. Clin. Invest. 2004, 114:427-437.
26. Nicholas K.B., Nicholas H.B., Deerfield D.W. GeneDoc: analysis and visualization of genetic variation. EMBNEW. NEWS 1997, 4:14.
27. Goring H.H.H., Curran J.E., Johnson M.P., Dyer T.D., Charlesworth J., Cole S.A., et al. Discovery of expression QTLs using large-scale transcriptional profiling in human lymphocytes. Nat. Genet. 2007, 39:1208-1216.
28. Pruitt K.D., Tatusova T., Maglott D.R. NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res. 2005, 33:D501-D504.
29. Cox L.A., Mahaney M.C., VandeBerg J.L., Rogers J. A second-generation genetic linkage map of the baboon (Papio hamadryas) genome. Genomics 2006, 88:274-281.
30. Almasy L., Blangero J. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 1998, 62:1198-1211.
31. Blangero J., Williams J.T., Almasy L. Variance component methods for detecting complex trait loci. Adv. Genet. 2001, 42:151-181.
32. Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach. J. R. Stat. Soc. B 1995, 57:289-300.
33. Mantel N. The detection of disease clustering and a generalized regression approach. Cancer Res. 1967, 27:209-220.
34. Heath S.C. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models. Am. J. Hum. Genet. 1997, 61:748-760.
35. Ott J. Analysis of human genetic linkage 1999, The Johns Hopkins University Press, Baltimore, MD. 3rd ed.
36. Feingold E., Brown P.O., Siegmund D. Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. Am. J. Hum. Genet. 1993, 53:234-251.
37. Goring H.H.H., Terwilliger J.D., Blangero J. Large upward bias in estimation of locus-specific effects from genomewide scans. Am. J. Hum. Genet. 2001, 69:1357-1369.
38. Ouyang C., Smith D.D., Krontiris T.G. Evolutionary signatures of common human cis-regulatory haplotypes. PLoS ONE 2008, 3:e3362.