The role of interneurons in shaping purkinje cell responses in the cerebellar cortex

Journal of Neuroscience

Volumn 31, Issue 29, 2011, Pages 10463-10473

  Dizon, Maria Johanna ^a   Khodakhah, Kamran ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN MAPPING; CELL FUNCTION; CELL SHAPE; CEREBELLUM CORTEX; CONTROLLED STUDY; DENDRITE; ELECTROSTIMULATION; EXCITATION; FEMALE; GABAERGIC TRANSMISSION; GRANULE CELL; INTERNEURON; MALE; NONHUMAN; ORIENTATION; PHOTOLYSIS; PRIORITY JOURNAL; PURKINJE CELL; RAT; STEREOTYPY;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ACTION POTENTIALS; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBELLAR CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; INTERNEURONS; MYASTHENIC SYNDROMES, CONGENITAL; NERVE NET; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; PHOSPHINIC ACIDS; PHOTIC STIMULATION; PHOTOLYSIS; PICROTOXIN; PROPANOLAMINES; PURKINJE CELLS; PYRIDAZINES; RATS; RATS, WISTAR;

EID: 79960687804     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1350-11.2011     Document Type: Article

References (40)

1. Andersen P, Eccles JC, Voorhoeve PE (1964) Postsynaptic inhibition of cerebellar Purkinje cells. J Neurophysiol 27:1138-1153.
2. Bower JM (2010) Model-founded explorations of the roles of molecular layer inhibition in regulating Purkinje cell responses in cerebellar cortex: more trouble for the beam hypothesis. Front Cell Neurosci 4:pii:27.
3. Brunel N, Hakim V, Isope P, Nadal JP, Barbour B (2004) Optimal information storage and the distribution of synaptic weights: perceptron versus Purkinje cell. Neuron 43:745-757.
4. Chadderton P, Margrie TW, Häusser M (2004) Integration of quanta in cerebellar granule cells during sensory processing. Nature 428:856- 860.
5. Cohen D, Yarom Y (1998) Patches of synchronized activity in the cerebellar cortex evoked by mossy-fiber stimulation: questioning the role of parallel fibers. Proc Natl Acad Sci U S A 95:15032-15036.
6. Cohen D, Yarom Y (2000a) Cerebellar on-beam and lateral inhibition: two functionally distinct circuits. J Neurophysiol 83:1932-1940.
7. Cohen D, Yarom Y (2000b) Unravelling cerebellar circuitry: an optical imaging study. Prog Brain Res 124:107-114.
8. Dieudonne S (1998) Infmillisecond kinetics and low efficacy of parallel fibre Golgi cell synaptic currents in the rat cerebellum. J Physiol 510:845-866.
9. Eccles JC (1973) The cerebellum as a computer: patterns in space and time. J Physiol 229:1-32.
10. Eccles JC, Ito M, Szenthagothai J (1967) The cerebellum as a neuronal machine. Heidelberg: Springer.
11. Fino E, Araya R, Peterka DS, Salierno M, Etchenique R, Yuste R (2009) RuBi-glutamate: two-photon and visible-light photoactivation of neurons and dendritic spines. Front Neural Circuits 3:2.
12. Gao W, Chen G, Reinert KC, Ebner TJ (2006) Cerebellar cortical molecular layer inhibition is organized in parasagittal zones. J Neurosci 26:8377- 8387.
13. Hamann M, Rossi DJ, Attwell D (2002) Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron 33:625-633.
14. Harvey RJ, Napper RM (1991) Quantitative studies on the mammalian cerebellum. Prog Neurobiol 36:437- 463.
15. Häusser M, Clark BA (1997) Tonic synaptic inhibition modulates neuronal output pattern and spatiotemporal synaptic integration. Neuron 19:665-678.
16. Herson PS, Virk M, Rustay NR, Bond CT, Crabbe JC, Adelman JP, Maylie J (2003) A mouse model of episodic ataxia type-1. Nat Neurosci 6:378 -383.
17. Ito M (1984) The cerebellum and neural control. New York: Raven Press.
18. Jaeger D, Bower JM (1994) Prolonged responses in rat cerebellar Purkinje cells following activation of the granule cell layer: an intracellular in vitro and in vivo investigation. Exp Brain Res 100:200-214.
19. Jörntell H, Ekerot CF (2006) Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J Neurosci 26:11786-11797.
20. Kanichay RT, Silver RA (2008) Synaptic and cellular properties of the feedforward inhibitory circuit within the input layer of the cerebellar cortex. J Neurosci 28:8955- 8967.
21. Mittmann W, Häusser M (2007) Linking synaptic plasticity and spike output at excitatory and inhibitory synapses onto cerebellar Purkinje cells. J Neurosci 27:5559-5570.
22. Mittmann W, Koch U, Häusser M (2005) Feed-forward inhibition shapes the spike output of cerebellar Purkinje cells. J Physiol 563:369-378.
23. Napper RM, Harvey RJ (1988) Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. J Comp Neurol 274:168-177.
24. Ovsepian SV, Friel DD (2010) Enhanced synaptic inhibition disrupts the efferent code of cerebellar Purkinje neurons in leaner Cav2.1 Ca2 channel mutant mice. Cerebellum. Advance online publication. Retrieved June 16, 2011. doi:10.1007/s12311-010-0210-9.
25. Palay SL, Chan-Palay V (1974) Cerebellar cortex. Berlin: Springer
26. Raman IM, Bean BP (1999) Ionic currents underlying spontaneous action potentials in isolated cerebellar Purkinje neurons. J Neurosci 19:1663-1674.
27. Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, Häusser M (2007) High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature 450:1245-1248.
28. Rossi DJ, Hamann M (1998) Spillover-mediated transmission at inhibitory synapses promoted by high affinity α6 infunit GABAA receptors and glomerular geometry. Neuron 20:783-795.
29. Santamaria F, Tripp PG, Bower JM (2007) Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex. J Neurophysiol 97:248-263.
30. Sullivan MR, Nimmerjahn A, Sarkisov DV, Helmchen F, Wang SS (2005) In vivo calcium imaging of circuit activity in cerebellar cortex. J Neurophysiol 94:1636-1644.
31. Sultan F (2001) Distribution of mossy fibre rosettes in the cerebellum of cat and mice: evidence for a parasagittal organization at the single fibre level. Eur J Neurosci 13:2123-2130.
32. Sultan F, Bower JM (1998) Quantitative Golgi study of the rat cerebellar molecular layer interneurons using principal component analysis. J Comp Neurol 393:353-373.
33. Szentagothai J (1965) The use of degeneration methods in the investigation of short neuronal connexions. Prog Brain Res 14:1-32.
34. Thach WT (1968) Discharge of Purkinje and cerebellar nuclear neurons during rapidly alternating arm movements in the monkey. J Neurophysiol 31:785-797.
35. Thach WT (1970) Discharge of cerebellar neurons related to two maintained postures and two prompt movements. II. Purkinje cell output and input. J Neurophysiol 33:537-547.
36. Walter JT, Khodakhah K (2006) The linear computational algorithm of cerebellar Purkinje cells. J Neurosci 26:12861-12872.
37. Walter JT, Khodakhah K (2009) The advantages of linear information processing for cerebellar computation. Proc Natl Acad Sci U S A 106:4471-4476.
38. Walter JT, Dizon MJ, Khodakhah K (2009) The functional equivalence of ascending and parallel fiber inputs in cerebellar computation. J Neurosci 29:8462- 8473.
39. Wulff P, Schonewille M, Renzi M, Viltono L, Sassoe-Pognetto M, Badura A, Gao Z, Hoebeek FE, van Dorp S, Wisden W, Farrant M, De Zeeuw CI (2009) Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nat Neurosci 12:1042-1049.
40. Zhang W, Linden DJ (2010) Calcium influx measured at single presynaptic boutons of cerebellar granule cell ascending axons and parallel fibers. Cerebellum. Advance online publication. Retrieved June 16, 2011. doi: 10.1007/s12311-009-0151-3.