The functional equivalence of ascending and parallel fiber inputs in cerebellar computation

Journal of Neuroscience

Volumn 29, Issue 26, 2009, Pages 8462-8473

  Walter, Joy T ^a   Dizon, Maria Johanna ^a   Khodakhah, Kamran ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BRAIN SLICE; CELL ACTIVITY; CEREBELLUM CORTEX; CONTROLLED STUDY; GRANULE CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MEMBRANE CURRENT; MOUSE; NERVE FIBER; NONHUMAN; PATCH TEST; PHOTOSTIMULATION; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; PURKINJE CELL; RAT;

AFFERENT PATHWAYS; AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; BRAIN MAPPING; CEREBELLUM; EXCITATORY AMINO ACID AGONISTS; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; GLUTAMATES; MEMBRANE POTENTIALS; NERVE FIBERS; PATCH-CLAMP TECHNIQUES; PHOSPHINIC ACIDS; PICROTOXIN; PROPANOLAMINES; PURKINJE CELLS; RATS; RATS, WISTAR;

EID: 67649949484     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5718-08.2009     Document Type: Article

References (47)

1. Albus JS (1971) A theory of cerebellar function. Math Biosci 10:25-61.
2. Barbour B (1993) Synaptic currents evoked in Purkinje cells by stimulating individual granule cells. Neuron 11:759-769.
3. Barbour B, Isope P (2000) Combining loose cell-attached stimulation and recording. J Neurosci Methods 103:199-208.
4. Bell CC, Grimm RJ (1969) Discharge properties of Purkinje cells recorded on single and double microelectrodes. J Neurophysiol 32:1044-1055.
5. Bower JM, Kassel J (1990) Variability in tactile projection patterns to cerebellar folia crus IIA of the Norway rat. J Comp Neurol 302:768-778.
6. Bower JM, Woolston DC (1983) Congruence of spatial organization of tactile projections to granule cell and Purkinje cell layers of cerebellar hemispheres of the albino rat: vertical organization of cerebellar cortex. J Neurophysiol 49:745-766.
7. Braitenberg V, Atwood RP (1958) Morphological observations on the cerebellar cortex. J Comp Neurol 109:1-33.
8. Canepari M, Nelson L, Papageorgiou G, Corrie JE, Ogden D (2001) Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters. J Neurosci Methods 112:29-42.
9. Chadderton P, Margrie TW, Häusser M (2004) Integration of quanta in cerebellar granule cells during sensory processing. Nature 428:856-860.
10. Clements JD, Silver RA (2000) Unveiling synaptic plasticity: a new graphical and analytical approach. Trends Neurosci 23:105-113.
11. Diño MR, Mugnaini E (2008) Distribution and phenotypes of unipolar brush cells in relation to the granule cell system of the rat cochlear nucleus. Neuroscience 154:29-50.
12. Eccles JC (1973) The cerebellum as a computer: patterns in space and time. J Physiol 229:1-32.
13. Eccles JC, Ito M, Szenthagothai J (1967) The cerebellum as a neuronal machine. Heidelberg: Springer.
14. Eccles JC, Sabah NH, Schmidt RF, Táboríková H (1972) Integration by Purkyne cells of mossy and climbing fiber inputs from cutaneous mechanoreceptors. Exp Brain Res 15:498-520.
15. Foster KA, Crowley JJ, Regehr WG (2005) The influence of multivesicular release and postsynaptic receptor saturation on transmission at granule cell to Purkinje cell synapses. J Neurosci 25:11655-11665.
16. Gundappa-Sulur G, De Schutter E, Bower JM (1999) Ascending granule cell axon: an important component of cerebellar cortical circuitry. J Comp Neurol 408:580-596.
17. Harris KM, Stevens JK (1988) Dendritic spines of rat cerebellar Purkinje cells: serial electron microscopy with reference to their biophysical characteristics. J Neurosci 8:4455-4469.
18. Harvey RJ, Napper RM (1991) Quantitative studies on the mammalian cerebellum. Prog Neurobiol 36:437-463.
19. Isope P, Barbour B (2002) Properties of unitary granule cell→Purkinje cell synapses in adult rat cerebellar slices. J Neurosci 22:9668-9678.
20. Ito M (1984) The cerebellum and neural control. New York: Raven.
21. Jaeger D, Bower JM (1994) Prolonged responses in rat cerebellar Purkinje cells following activation of the granule cell layer: an intracellular in vitro and in vivo investigation. Exp Brain Res 100:200-214.
22. Jörntell H, Ekerot CF (2006) Properties of somatosensory synaptic integration in cerebellar granule cells in vivo. J Neurosci 26:11786-11797.
23. Khodakhah K, Ogden D (1995) Fast activation and inactivation of inositol trisphosphate-evoked Ca2+ release in rat cerebellar Purkinje neurones. J Physiol 487:343-358.
24. Korn H, Fassnacht C, Faber DS (1991) Is maintenance of LTP presynaptic? Nature 350:282.
25. Llinas R (1982) General discussion: radial connectivity in the cerebellar cortex. A novel view regarding the functional organization of the molecular layer. In: The cerebellum: new vistas (Palay SL, Chan-Palay V, eds), pp 189-194. Berlin: Springer.
26. Lu H, Esquivel AV, Bower JM (2009) 3D electron microscopic reconstruction of segments of rat cerebellar Purkinje cell dendrites receiving ascending and parallel fiber granule cell synaptic inputs. J Comp Neurol 514:583-594.
27. Marcaggi P, Attwell D (2007) Short-and long-term depression of rat cerebellar parallel fibre synaptic transmission mediated by synaptic crosstalk. J Physiol 578:545-550.
28. Marr D (1969) A theory of cerebellar cortex. J Physiol 202:437-470.
29. Mugnaini E (1972) The histology and cytology of the cerebellar cortex. In: The comparative anatomy and histology of the human cerebellum: the human cerebellum, cerebellar connections, and cerebellar cortex (Larsell O, Jansen J, eds), pp 201-262. Minneapolis: University of Minnesota.
30. Napper RM, Harvey RJ (1988) Number of parallel fiber synapses on an individual Purkinje cell in the cerebellum of the rat. J Comp Neurol 274:168-177.
31. Nunzi MG, Shigemoto R, Mugnaini E (2002) Differential expression of calretinin and metabotropic glutamate receptor mGluR1alpha defines subsets of unipolar brush cells in mouse cerebellum. J Comp Neurol 451:189-199.
32. Palay SL, Chan-Palay V (1974) Cerebellar cortex. Berlin: Springer.
33. Pichitpornchai C, Rawson JA, Rees S (1994) Morphology of parallel fibres in the cerebellar cortex of the rat: an experimental light and electron microscopic study with biocytin. J Comp Neurol 342:206-220.
34. Rancz EA, Ishikawa T, Duguid I, Chadderton P, Mahon S, Häusser M (2007) High-fidelity transmission of sensory information by single cerebellar mossy fibre boutons. Nature 450:1245-1248.
35. Russo MJ, Mugnaini E, Martina M (2007) Intrinsic properties and mechanisms of spontaneous firing in mouse cerebellar unipolar brush cells. J Physiol 581:709-724.
36. Santamaria F, Bower JM (2005) Background synaptic activity modulates the response of a modeled Purkinje cell to paired afferent input. J Neurophysiol 93:237-250.
37. Santamaria F, Jaeger D, De Schutter E, Bower JM (2002) Modulatory effects of parallel fiber and molecular layer interneuron synaptic activity on Purkinje cell responses to ascending segment input: a modeling study. J Comput Neurosci 13:217-235.
38. Santamaria F, Tripp PG, Bower JM (2007) Feedforward inhibition controls the spread of granule cell-induced Purkinje cell activity in the cerebellar cortex. J Neurophysiol 97:248-263.
39. Sekerková G, Diño MR, Ilijic E, Russo M, Zheng L, Bartles JR, Mugnaini E (2007) Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum. Neuroscience 145:116-129.
40. Shambes GM, Gibson JM, Welker W (1978) Fractured somatotopy in granule cell tactile areas of rat cerebellar hemispheres revealed by micromapping. Brain Behav Evol 15:94-140.
41. Sims RE, Hartell NA (2005) Differences in transmission properties and susceptibility to long-term depression reveal functional specialization of ascending axon and parallel fiber synapses to Purkinje cells. J Neurosci 25:3246-3257.
42. Sims RE, Hartell NA (2006) Differential susceptibility to synaptic plasticity reveals a functional specialization of ascending axon and parallel fiber synapses to cerebellar Purkinje cells. J Neurosci 26:5153-5159.
43. Sultan F (2001) Distribution of mossy fibre rosettes in the cerebellum of cat and mice: evidence for a parasagittal organization at the single fibre level. Eur J Neurosci 13:2123-2130.
44. Takács J, Markova L, Borostyánköi Z, Görcs TJ, Hámori J (1999) Metabotrop glutamate receptor type 1a expressing unipolar brush cells in the cerebellar cortex of different species: a comparative quantitative study. J Neurosci Res 55:733-748.
45. Walter JT, Khodakhah K (2006) The linear computational algorithm of cerebellar Purkinje cells. J Neurosci 26:12861-12872.
46. Walter JT, Khodakhah K (2009) The advantages of linear information processing for cerebellar computation. Proc Natl Acad Sci U S A 106:4471-4476.
47. Xu-Friedman MA, Harris KM, Regehr WG (2001) Three-dimensional comparison of ultrastructural characteristics at depressing and facilitating synapses onto cerebellar Purkinje cells. J Neurosci 21:6666-6672.