Prostaglandin E2-EP4 signaling suppresses adipocyte differentiation in mouse embryonic fibroblasts via an autocrine mechanism

Journal of Lipid Research

Volumn 52, Issue 8, 2011, Pages 1500-1508

  Inazumi, Tomoaki ^a   Shirata, Naritoshi ^a   Morimoto, Kazushi ^a   Takano, Hirotsugu ^a   Segi Nishida, Eri ^a   Sugimoto, Yukihiko ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Adipogenesis; Aspirin like drugs; Fat cell; Prostanoid; Receptor subtypes

Indexed keywords

CYCLOOXYGENASE 2; INDOMETACIN; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN E2; PROSTAGLANDIN F RECEPTOR; PROSTAGLANDIN RECEPTOR; UNCLASSIFIED DRUG; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROSTAGLANDIN E RECEPTOR; PTGS2 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; AUTOCRINE EFFECT; CELL DIFFERENTIATION; CONTROLLED STUDY; COX 2 GENE; EMBRYO; EMBRYO DEVELOPMENT; FIBROBLAST; GENE; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PPARG2 GENE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; WILD TYPE; ANIMAL; ANIMAL EMBRYO; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOCYTES; ADIPOGENESIS; ANIMALS; AUTOCRINE COMMUNICATION; CELL DIFFERENTIATION; CYCLOOXYGENASE 2; DINOPROSTONE; EMBRYO, MAMMALIAN; FEMALE; FIBROBLASTS; INDOMETHACIN; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PPAR GAMMA; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 79960673188     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M013615     Document Type: Article

References (36)

1. Gregoire, F. M., C. M. Smas, and H. S. Sul. 1998. Understanding adipocyte differentiation. Physiol. Rev. 78: 783-809.
2. Rosen, E. D., and B. M. Spiegelman. 2000. Molecular regulation of adipogenesis. Annu. Rev. Cell Dev. Biol. 16: 145-171.
3. Matsuzawa, Y. 2006. The metabolic syndrome and adipocytokines. FEBS Lett. 580: 2917-2921. (Pubitemid 43729162)
4. Karastergiou, K., and V. Mohamed-Ali. 2010. The autocrine and paracrine roles of adipokines. Mol. Cell. Endocrinol. 318: 69-78.
5. Coleman, R. A., W. L. Smith, and S. Narumiya. 1994. International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. Pharmacol. Rev. 46: 205-229.
6. Narumiya, S., Y. Sugimoto, and F. Ushikubi. 1999. Prostanoid receptors; structures, properties and functions. Physiol. Rev. 79: 1193-1226. (Pubitemid 29473315)
7. Sugimoto, Y., K. Hasumoto, T. Namba, A. Irie, M. Katsuyama, M. Negishi, A. Kakizuka, S. Narumiya, and A. Ichikawa. 1994. Cloning and expression of a cDNA for mouse PGF receptor. J. Biol. Chem. 269: 1356-1360. (Pubitemid 24032530)
8. 2-EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion. Nat. Med. 15: 633-640.
9. Sugimoto, Y., and S. Narumiya. 2007. Prostaglandin E receptors. J. Biol. Chem. 282: 11613-11617. (Pubitemid 47100657)
10. Curtis-Prior, P. B. 1975. Prostaglandins and obesity. Lancet. 1: 897-899.
11. Casimir, D. A., C. W. Miller, and J. M. Ntambi. 1996. Preadipocyte differentiation blocked by prostaglandin stimulation of prostanoid FP2 receptor in murine 3T3-L1 cells. Differentiation. 60: 203-210.
12. Kim, S., and N. Moustaid-Moussa. 2000. Secretory, endocrine and autocrine/paracrine function of the adipocyte. J. Nutr. 130: 3110S-3115S.
13. Fain, J. N., L. R. Ballou, and S. W. Bahouth. 2001. Obesity is induced in mice heterozygous for cyclooxygenase-2. Prostaglandins Other Lipid Mediat. 65: 199-209.
14. Tsuboi, H., Y. Sugimoto, T. Kainoh, and A. Ichikawa. 2004. Prostanoid EP4 receptor is involved in suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322: 1066-1072. (Pubitemid 39164462)
15. 2 suppression of 3T3-L1 adipocyte differentiation. Biochem. Biophys. Res. Commun. 322: 911-917.
16. Segi, E., Y. Sugimoto, A. Yamasaki, Y. Aze, H. Oida, T. Nishimura, T. Murata, T. Matsuoka, F. Ushikubi, M. Hirose, et al. 1998. Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem. Biophys. Res. Commun. 246: 7-12.
17. Sugimoto, Y., A. Yamasaki, E. Segi, K. Tsuboi, Y. Aze, T. Nishimura, H. Oida, N. Yoshida, T. Tanaka, M. Katsuyama, et al. 1997. Failure of parturition in mice lacking the prostaglandin F receptor. Science. 277: 681-684.
18. Kabashima, K., T. Saji, T. Murata, M. Nagamachi, T. Matsuoka, E. Segi, K. Tsuboi, Y. Sugimoto, T. Kobayashi, Y. Miyachi, et al. 2002. The prostaglandin E receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J. Clin. Invest. 109: 883-893. (Pubitemid 34275109)
19. Segi, E., K. Haraguchi, Y. Sugimoto, M. Tsuji, H. Tsunekawa, S. Tamba, K. Tsuboi, S. Tanaka, and A. Ichikawa. 2003. Expression of messenger RNA for prostaglandin E receptor subtypes EP4/ EP2 and cyclooxygenase isozymes in mouse periovulatory follicles and oviducts during superovulation. Biol. Reprod. 68: 804-811. (Pubitemid 36245823)
20. Sugimoto, Y., M. Negishi, Y. Hayashi, T. Namba, A. Honda, A. Watabe, M. Hirata, S. Narumiya, and A. Ichikawa. 1993. Two isoforms of EP3 receptor with different C-terminal domains; identical ligand binding properties and different coupling properties with Gi proteins. J. Biol. Chem. 268: 2712-2718. (Pubitemid 23057900)
21. Irie, A., Y. Sugimoto, A. Namba, A. Harazono, A. Honda, A. Watabe, M. Negishi, S. Narumiya, and A. Ichikawa. 1993. Third isoform of the prostaglandin-E-receptor EP3 subtype with different C-terminal tail coupling to both stimulation and inhibition of adenylate cyclase. Eur. J. Biochem. 217: 313-318. (Pubitemid 23305301)
22. Vassaux, G., D. Gaillard, C. Darimont, G. Ailhaud, and R. Negrel. 1992. Differential response of preadipocytes and adipocytes to prostacyclin and prostaglandin E2: physiological implications. Endocrinology. 131: 2393-2398.
23. 2+-elevating agent. J. Biol. Chem. 267: 11092-11097.
24. Fajas, L., S. Miard, M. R. Briggs, and J. Auwerx. 2003. Selective cyclo-oxygenase-2 inhibitors impair adipocyte differentiation through inhibition of the clonal expansion phase. J. Lipid Res. 44: 1652-1659. (Pubitemid 37185875)
25. Yan, H., A. Kermouni, M. Abdel-Hafez, and D. C. Lau. 2003. Role of cyclooxygenases COX-1 and COX-2 in modulating adipogenesis in 3T3-L1 cells. J. Lipid Res. 44: 424-429.
26. Chu, X., K. Nishimura, M. Jisaka, T. Nagaya, F. Shono, and K. Yokota. 2010. Up-regulation of adipogenesis in adipocytes expressing stably cyclooxygenase-2 in the antisense direction. Prostaglandins Other Lipid Mediat. 91: 1-9.
27. Yokota, T., C. S. Meka, K. L. Medina, H. Igarashi, P. C. Comp, M. Takahashi, M. Nishida, K. Oritani, J. Miyagawa, T. Funahashi, et al. 2002. Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins. J. Clin. Invest. 109: 1303-1310. (Pubitemid 34546894)
28. Börglum, J. D., S. B. Pedersen, G. Ailhaud, R. Negrel, and B. Richelsen. 1999. Differential expression of prostaglandin receptor mRNAs during adipose cell differentiation. Prostaglandins Other Lipid Mediat. 57: 305-317. (Pubitemid 29408682)
29. Jaworski, K., M. Ahmadian, R. E. Duncan, E. Sarkadi-Nagy, K. A. Varady, M. K. Hellerstein, H. Y. Lee, V. T. Samuel, G. I. Shulman, K. H. Kim, et al. 2009. AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency. Nat. Med. 15: 159-168.
30. Duncan, R. E., E. Sarkadi-Nagy, K. Jaworski, M. Ahmadian, and H. S. Sul. 2008. Identification and functional characterization of adipose-specific phospholipase A 2 (AdPLA). J. Biol. Chem. 283: 25428-25436.
31. Caplan, A. I., and S. P. Bruder. 2001. Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mol. Med. 7: 259-264.
32. Gimble, J. M., S. Zvonic, Z. E. Floyd, M. Kassem, and M. E. Nuttall. 2006. Playing with bone and fat. J. Cell. Biochem. 98: 251-266.
33. Muruganandan, S., A. A. Roman, and C. J. Sinal. 2009. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell. Mol. Life Sci. 66: 236-253.
34. Akune, T., S. Ohba, S. Kamekura, M. Yamaguchi, U. I. Chung, N. Kubota, Y. Terauchi, Y. Harada, Y. Azuma, K. Nakamura, et al. 2004. PPARγiciency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J. Clin. Invest. 113: 846-855. (Pubitemid 38544143)
35. Sen, B., Z. Xie, N. Case, M. Ma, C. Rubin, and J. Rubin. 2008. Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable βin signal. Endocrinology. 149: 6065-6075.
36. Yoshida, K., H. Oida, T. Kobayashi, T. Maruyama, M. Tanaka, T. Katayama, K. Yamaguchi, E. Segi, T. Tsuboyama, M. Matsushita, et al. 2002. Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc. Natl. Acad. Sci. USA. 99: 4580-4585. (Pubitemid 34286027)