Intravesical therapy for urothelial carcinoma of the bladder

Indian Journal of Urology

Volumn 27, Issue 2, 2011, Pages 252-261

  Manoharan, M ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Bladder; cancer; chemotherapy; intravesical

Indexed keywords

ANTIINFECTIVE AGENT; APAZIQUONE; BCG VACCINE; DOXORUBICIN; EPIRUBICIN; GEMCITABINE; IMMUNOMODULATING AGENT; INTERFERON; MITOMYCIN C; OXYBUTYNIN; PHENAZOPYRIDINE; PROPANTHELINE BROMIDE;

ADJUVANT THERAPY; ALLERGIC REACTION; BLADDER CARCINOMA; BONE MARROW SUPPRESSION; CALCIFICATION; CHEMICAL CYSTITIS; CONFERENCE PAPER; CONTACT DERMATITIS; DNA SYNTHESIS; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG WITHDRAWAL; DYSURIA; FEVER; HEMATURIA; HEPATITIS; HUMAN; MAINTENANCE THERAPY; META ANALYSIS; PNEUMONIA; PROSTATITIS; RISK ASSESSMENT; SEPSIS; TRANSITIONAL CELL CARCINOMA; URETER OBSTRUCTION;

EID: 79960664405     PISSN: 09701591     EISSN: 19983824     Source Type: Journal    
DOI: 10.4103/0970-1591.82846     Document Type: Conference Paper

References (81)

1. Parkin DM. The global burden of urinary bladder cancer. Scand J Urol Nephrol Suppl 2008;218:12-20.
2. O'Donnell MA. Practical applications of intravesical chemotherapy and immunotherapy in high-risk patients with superficial bladder cancer. Urol Clin North Am 2005:32:121-31. (Pubitemid 40613039)
3. Adiyat KT, Katkoori D, Soloway CT, De los Santos R, Manoharan M, Soloway MS. Complete transurethral resection of bladder tumor: Are the guidelines being followed? Urology 2010;75:365-7.
4. Shelley MD, Wilt TJ, Court J, Coles B, Kynaston H, Mason MD. Intravesical bacillus Calmette-Guerin is superior to mitomycin C in reducing tumour recurrence in high-risk superficial bladder cancer: A meta-analysis of randomized trials. BJU Int 2004;93:485-90.
5. Sylvester RJ, Oosterlinck W, van der Meijden AP. A single immediate postoperative instillation of chemotherapy decreases the risk of recurrence in patients with stage Ta T1 bladder cancer: A meta-analysis of published results of randomized clinical trials. J Urol 2004;171:2186-90. (Pubitemid 38625431)
6. Weldon TE, Soloway MS. Susceptibility of urothelium to neoplastic cellular implantation. Urology 1975;5:824-7.
7. Soloway MS. Rationale for intensive intravesical chemotherapy for superficial bladder cancer. J Urol 1980;123:461-6. (Pubitemid 10103826)
8. Sylvester RJ, van der Meijden AP, Oosterlinck W, Witjes JA, Bouffioux C, Denis L, et al. Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: A combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006;49:466-5.
9. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Bohle A, Palou-Redorta J. EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol 2008;54:303-14.
10. Morales A, Eidinger D, Bruce AW. Intracavitary bacillus calmette-guerin in the treatment of superficial bladder tumors. J Urol 1976;116:180-3.
11. Bohle A, Jocham D, Bock PR. Intravesical bacillus Calmette-Guerin versus mitomycin C for superficial bladder cancer: A formal meta-analysis of comparative studies on recurrence and toxicity. J Urol 2003;169:90-5. (Pubitemid 35461559)
12. Han RF, Pan JG. Can intravesical bacillus Calmette-Guerin reduce recurrence in patients with superficial bladder cancer? A meta-analysis of randomized trials. Urology 2006;67:1216-23 (Pubitemid 43818066)
13. Malmstrom PU, Sylvester RJ. An individual patient data meta-analysis of the long-term outcome of randomised studies comparing intravesical mitomycin C versus bacillus Calmette-Guerin for non-muscle-invasive bladder cancer. Eur Urol 2009;56:247-56.
14. Brandau S, Suttmann H. Thirty years of BCG immunotherapy for non-muscle invasive bladder cancer: A success story with room for improvement. Biomed Pharmacother 2007;61:299-305. (Pubitemid 47189735)
15. Zlotta AR, van Vooren JP, Huygen K, Drowart A, Decock M, Pirson M, et al. What is the optimal regimen for BCG intravesical therapy? Are six weekly instillations necessary? Eur Urol 2000;37:470-7. (Pubitemid 30157810)
16. Sylvester RJ, van der Meijden A, Witjes JA, Jakse G, Nonomura N, Cheng C, et al. High-grade Ta urothelial carcinoma and carcinoma in situ of the bladder. Urology 2005;66:90-107. (Pubitemid 43049611)
17. Sylvester RJ, van der MA, Lamm DL. Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: A meta-analysis of the published results of randomized clinical trials. J Urol 2002;168:1964-70.
18. Martnez-Pieiro JA, Martnez-Pieiro L, Solsona E, Rodrguez RH, Gmez JM, Martn MG, et al. Has a 3-fold decreased dose of bacillus Calmette-Guerin the same efficacy against recurrences and progression of T1G3 and Tis bladder tumors than the standard dose? Results of a prospective randomized trial. J Urol 2005;174:1242-7. (Pubitemid 41318691)
19. Andius P, Fehrling M, Holmang S. Intravesical bacillus Calmette-Guerin therapy: Experience with a reduced dwell-time in patients with pronounced side-effects. BJU Int 2005;96:1290-3. (Pubitemid 41743926)
20. Koya MP, Simon MA, Soloway MS. Complications of intravesical therapy for urothelial cancer of the bladder. J Urol 2006;175:2004-10. (Pubitemid 43668507)
21. Patard JJ, Rodriguez A, Leray E, Rioux-Leclercq N, Guille F, Lobel B. Intravesical Bacillus Calmette-Guerin treatment improves patient survival in T1G3 bladder tumours. Eur Urol 2002;41:635-41.
22. Shahin O, Thalmann GN, Rentsch C, Mazzucchelli L, Studer UE. A retrospective analysis of 153 patients treated with or without intravesical bacillus Calmette-Guerin for primary stage T1 grade 3 bladder cancer: Recurrence, progression and survival. J Urol 2003;169:96-100. (Pubitemid 35461560)
23. Hall MC, Chang SS, Dalbagni G, Pruthi RS, Seigne JD, Skinner EC, et al. Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update. J Urol 2007;178:2314-30. (Pubitemid 350080987)
24. Gontero P, Bohle A, Malmstrom PU, O'Donnell MA, Oderda M, Sylvester R, et al. The role of bacillus Calmette-Guerin in the treatment of non-muscle-invasive bladder cancer. Eur Urol 2010;57:410-29.
25. Naito K, Hisazumi H, Uchibayashi T, Amano T, Hirata A, Komatsu K, et al. Integral laser photodynamic treatment of refractory multifocal bladder tumors. J Urol 1991;146:1541-5.
26. Belldegrun AS, Franklin JR, O'Donnell MA, Gomella LG, Klein E, Neri R, et al. Superficial bladder cancer: The role of interferon-alpha. J Urol 1998;159:1793-801. (Pubitemid 29190700)
27. Torti FM, Shortliffe LD, Williams RD, Pitts WC, Kempson RL, Ross JC, et al. Alpha-interferon in superficial bladder cancer: A Northern California Oncology Group Study. J Clin Oncol 1988;6:476-83. (Pubitemid 18090695)
28. Glashan RW. A randomized controlled study of intravesical alpha-2b-interferon in carcinoma in situ of the bladder. J Urol 1990;144:658-61. (Pubitemid 20296718)
29. Klble T, Beer M, Mendoza E, Ikinger U, Link M, Reichert HE, et al. BCG vs interferon A for prevention of recurrence of superficial bladder cancer: A prospective randomized study. Urologe A 1994;33:133-7. (Pubitemid 24104481)
30. Bercovich E, Deriu M, Manferrari F, Irianni G. BCG vs. BCG plus recombinant alpha-interferon 2b in superficial tumors of the bladder. Arch Ital Urol Androl 1995;67:257-60.
31. Stricker P, Pryor K, Nicholson T, Goldstein D, Golovsky D, Ferguson R, et al. Bacillus Calmette-Guerin plus intravesical interferon alpha-2b in patients with superficial bladder cancer. Urology 1996;48:957-61.
32. Lamm DL, Torti FM. Bladder cancer, 1996. CA Cancer J Clin 1996;46:93-112.
33. Gasion JP, Cruz JF. Improving efficacy of intravesical chemotherapy. Eur Urol 2006;50:225-34. (Pubitemid 44041091)
34. Wientjes MG, Badalament RA, Au JL. Use of pharmacologic data and computer simulations to design an efficacy trial of intravesical mitomycin C therapy for superficial bladder cancer. Cancer Chemother Pharmacol. 1993:32:255-62. (Pubitemid 23172082)
35. Sternberg CN, Donat SM, Bellmunt J, Millikan RE, Stadler W, De Mulder P, et al. Chemotherapy for bladder cancer: Treatment guidelines for neoadjuvant chemotherapy, bladder preservation, adjuvant chemotherapy, and metastatic cancer. Urology 2007;69:62-79. (Pubitemid 46186484)
36. Nieder AM, Brausi M, Lamm D, O'Donnell M, Tomita K, Woo H, et al. Management of stage T1 tumors of the bladder: International Consensus Panel. Urology 2005;66:108-25. (Pubitemid 43049612)
37. Oosterlinck W, Solsona E, Akaza H, Busch C, Goebell PJ, Malmstrm PU, et al. Low-grade Ta (noninvasive) urothelial carcinoma of the bladder. Urology 2005;66:75-89. (Pubitemid 43049610)
38. Sylvester RJ, van der Meijden AP, Witjes JA, Kurth K. Bacillus calmette-guerin versus chemotherapy for the intravesical treatment of patients with carcinoma in situ of the bladder: A meta-analysis of the published results of randomized clinical trials. J Urol 2005;174:86-91. (Pubitemid 40825679)
39. Kaasinen E, Rintala E, Hellstrm P, Viitanen J, Juusela H, Rajala P, et al. Factors explaining recurrence in patients undergoing chemoimmunotherapy regimens for frequently recurring superficial bladder carcinoma. Eur Urol 2002;42:167-74.
40. Pawinski A, Sylvester R, Kurth KH, Bouffioux C, van der Meijden A, Parmar MK, et al. A combined analysis of European Organization for Research and Treatment of Cancer, and Medical Research Council randomized clinical trials for the prophylactic treatment of stage TaT1 bladder cancer: European Organization for Research and Treatment of Cancer Genitourinary Tract Cancer Cooperative Group and the Medical Research Council Working Party on Superficial Bladder Cancer. J Urol 1996;156:1934-40.
41. Lamm DL, Riggs DR, Traynelis CL, Nseyo UO. Apparent failure of current intravesical chemotherapy prophylaxis to influence the long-term course of superficial transitional cell carcinoma of the bladder. J Urol 1995;153:1444-50.
42. Bouffioux C, Kurth KH, Bono A, Oosterlinck W, Kruger CB, De Pauw M, et al. Intravesical adjuvant chemotherapy for superficial transitional cell bladder carcinoma: Results of 2 European Organization for Research and Treatment of Cancer randomized trials with mitomycin C and doxorubicin comparing early versus delayed instillations and short-term versus long-term treatment: European Organization for Research and Treatment of Cancer Genitourinary Group. J Urol 1995;153:934-41.
43. Witjes JA, Hendricksen K. Intravesical pharmacotherapy for non-muscle-invasive bladder cancer: A critical analysis of currently available drugs, treatment schedules, and long-term results. Eur Urol 2008;53:45-52. (Pubitemid 350167566)
44. Smith JA Jr, Labasky RF, Cockett AT, Fracchia JA, Montie JE, Rowland RG. Bladder cancer clinical guidelines panel summary report on the management of nonmuscle invasive bladder cancer (stages Ta, T1 and TIS): The American Urological Association. J Urol 1999;162:1697-701. (Pubitemid 29474702)
45. Lamm DL. Long-term results of intravesical therapy for superficial bladder cancer. Urol Clin North Am 1992;19:573-80.
46. Bouffioux C, van der Meijden A, Kurth KH, Jakse G, Bono A, Hall R, et al. Objective response of superficial bladder tumors to intravesical treatment (including review of response of marker lesions). Prog Clin Biol Res 1992;378:29-42.
47. Witjes JA, Meijden AP, Collette L, Sylvester R, Debruyne FM, van Aubel A, et al. Long-term follow-up of an EORTC randomized prospective trial comparing intravesical bacille Calmette-Guerin-RIVM and mitomycin C in superficial bladder cancer: EORTC GU Group and the Dutch South East Cooperative Urological Group: European Organisation for Research and Treatment of Cancer Genito-Urinary Tract Cancer Collaborative Group. Urology 1998;52:403-10.
48. Witjes JA, vd Meijden AP, Witjes WP, Doesburg W, Schaafsma HE, Debruyne FM. A randomised prospective study comparing intravesical instillations of mitomycin-C, BCG-Tice, and BCG-RIVM in pTa-pT1 tumours and primary carcinoma in situ of the urinary bladder: Dutch South-East Cooperative Urological Group. Eur J Cancer 1993:29A:1672-6. (Pubitemid 23275867)
49. Bartoletti R, Cai T, Gacci M, Giubilei G, Viggiani F, Santelli G, et al. Intravesical gemcitabine therapy for superficial transitional cell carcinoma: Results of a Phase II prospective multicenter study. Urology 2005;66:726-31. (Pubitemid 41440812)
50. Huncharek M, Kupelnick B. The influence of intravesical therapy on progression of superficial transitional cell carcinoma of the bladder: A metaanalytic comparison of chemotherapy versus bacilli Calmette-Guerin immunotherapy. Am J Clin Oncol 2004;27:522-8. (Pubitemid 39371952)
51. Huland H, Klppel G, Feddersen I, Otto U, Brachmann W, Hubmann H, et al. Comparison of different schedules of cytostatic intravesical instillations in patients with superficial bladder carcinoma: Final evaluation of a prospective multicenter study with 419 patients. J Urol 1990;144:68-71. (Pubitemid 20221270)
52. Richie JP. Intravesical chemotherapy: Treatment selection, techniques, and results. Urol Clin North Am 1992;19:521-7.
53. Malmstrom PU, Wijkstrom H, Lundholm C, Wester K, Busch C, Norlen BJ. 5-year followup of a randomized prospective study comparing mitomycin C and bacillus Calmette-Guerin in patients with superficial bladder carcinoma: Swedish-Norwegian Bladder Cancer Study Group. J Urol 1999;161:1124-7. (Pubitemid 29426100)
54. Au JL, Badalament RA, Wientjes MG, Young DC, Warner JA, Venema PL, et al. Methods to improve efficacy of intravesical mitomycin C: Results of a randomized phase III trial. J Natl Cancer Inst 2001;93:597-604. (Pubitemid 32409627)
55. Di Stasi SM, Giannantoni A, Stephen RL, Capelli G, Navarra P, Massoud R, et al. Intravesical electromotive mitomycin C versus passive transport mitomycin C for high risk superficial bladder cancer: A prospective randomized study. J Urol 2003;170:777-82. (Pubitemid 36999554)
56. Lamm DL, Blumenstein BA, Crawford ED, Montie JE, Scardino P, Grossman HB, et al. A randomized trial of intravesical doxorubicin and immunotherapy with bacille Calmette-Guerin for transitional-cell carcinoma of the bladder. N Engl J Med 1991;325:1205-9.
57. Thrasher JB, Crawford ED. Complications of intravesical chemotherapy. Urol Clin North Am 1992;19:529-39.
58. Onrust SV, Wiseman LR, Goa KL. Epirubicin: A review of its intravesical use in superficial bladder cancer. Drugs Aging 1999;15:307-33. (Pubitemid 29504953)
59. Tsushima T, Miyaji Y, Noda M, Nasu Y, Kumon H, Ohmori H. Absorption of epirubicin instilled intravesically immediately after transurethral resection of superficial bladder cancer. Urol Int 1998;60:161-4. (Pubitemid 28282421)
60. Burk K, Kurth KH, Newling D. Epirubicin in treatment and recurrence prophylaxis of patients with superficial bladder cancer. Prog Clin Biol Res 1989;303:423-34.
61. Liu B, Zhang Y, Wang Z, Ding Q, Chen B, Wang J, et al. Single instillation of epirubicin for the prophylaxis of recurrent primary superficial bladder carcinoma. Zhonghua Wai Ke Za Zhi 2002;40:112-5.
62. Rajala P, Kaasinen E, Raitanen M, Liukkonen T, Rintala E. Perioperative single dose instillation of epirubicin or interferon-alpha after transurethral resection for the prophylaxis of primary superficial bladder cancer recurrence: A prospective randomized multicenter study-FinnBladder III long-term results. J Urol 2002;168:981-5.
63. Okamura K, Murase T, Obata K, Ohshima S, Ono Y, Sakata T, et al. A randomized trial of early intravesical instillation of epirubicin in superficial bladder cancer: The Nagoya University Urological Oncology Group. Cancer Chemother Pharmacol 1994;35:S31-5. (Pubitemid 24357238)
64. Eto H, Oka Y, Ueno K, Nakamura I, Yoshimura K, Arakawa S, et al. Comparison of the prophylactic usefulness of epirubicin and doxorubicin in the treatment of superficial bladder cancer by intravesical instillation: A multicenter randomized trial: Kobe University Urological Oncology Group. Cancer Chemother Pharmacol 1994;35:S46-51. (Pubitemid 24357241)
65. Kondo T, Onitsuka S, Ryoji O, Kihara T, Goto Y, Satoh T, et al. Analysis of prognostic factors related to primary superficial bladder cancer tumor recurrence in prophylactic intravesical epirubicin therapy. Int J Urol 1999;6:178-83. (Pubitemid 30406839)
66. Torelli F, Catanzaro F, Conti G, Comeri CG, Risi O, Pino R, et al. High-dose epirubicin in the prophylactic treatment of T1G2 superficial bladder tumors. Eur Urol 2001;39:11-4. (Pubitemid 32171197)
67. Okamura K, Kinukawa T, Tsumura Y, Otani T, Itoh H, Kobayashi H, et al. A randomized study of short-versus long-term intravesical epirubicin instillation for superficial bladder cancer: Nagoya University Urological Oncology Group. Eur Urol 1998;33:285-8.
68. de Groot AC, Conemans JM. Systemic allergic contact dermatitis from intravesical instillation of the antitumor antibiotic mitomycin C. Contact Dermatitis 1991;24:201-9.
69. Onrust SV, Lamb HM. Valrubicin. Drugs Aging 1999;15:69-75.
70. Steinberg G, Bahnson R, Brosman S, Middleton R, Wajsman Z, Wehle M. Efficacy and safety of valrubicin for the treatment of Bacillus Calmette-Guerin refractory carcinoma in situ of the bladder: The Valrubicin Study Group. J Urol 2000;163:761-7. (Pubitemid 30091611)
71. Newling DW, Hetherington J, Sundaram SK, Robinson MR, Kisbenedek L. The use of valrubicin for the chemoresection of superficial bladder cancer: A marker lesion study. Eur Urol 2001;39:643-7. (Pubitemid 32679632)
72. Patterson AL, Greenberg RE, Weems L, Bahnson R, Wajsman Z, Israel M, et al. Pilot study of the tolerability and toxicity of intravesical valrubicin immediately after transurethral resection of superficial bladder cancer. Urology 2000;56:232-5. (Pubitemid 30495573)
73. Gontero P, Fiorito C, Lucca I, Valentino F, Tizzani A. New drugs currently available in non-muscle invasive bladder cancer: Update on gemcitabine studies. Arch Ital Urol Androl 2008;80:162-6.
74. Laufer M, Ramalingam S, Schoenberg MP, Haisfield-Wolf ME, Zuhowski EG, Trueheart IN, et al. Intravesical gemcitabine therapy for superficial transitional cell carcinoma of the bladder: A phase I and pharmacokinetic study. J Clin Oncol 2003;21:697-703. (Pubitemid 46621905)
75. Dalbagni G, Russo P, Sheinfeld J, Mazumdar M, Tong W, Rabbani F, et al. Phase I trial of intravesical gemcitabine in bacillus Calmette-Guerin-refractory transitional-cell carcinoma of the bladder. J Clin Oncol 2002;20:3193-8. (Pubitemid 34831514)
76. Gontero P, Casetta G, Maso G, Sogni F, Pretti G, Zitella A, et al. Phase II study to investigate the ablative efficacy of intravesical administration of gemcitabine in intermediate-risk superficial bladder cancer (SBC). Eur Urol 2004;46:339-43. (Pubitemid 39078568)
77. Dalbagni G, Russo P, Bochner B, Ben-Porat L, Sheinfeld J, Sogani P, et al. Phase II trial of intravesical gemcitabine in bacille Calmette-Guerin- refractory transitional cell carcinoma of the bladder. J Clin Oncol 2006;24:2729-34. (Pubitemid 46630569)
78. Mohanty NK, Nayak RL, Vasudeva P, Arora RP. Intravesicle gemcitabine in management of BCG refractory superficial TCC of urinary bladder-our experience. Urol Oncol 2008;26:616-9.
79. Maffezzini M, Campodonico F, Canepa G, Capponi G, Fontana V. Short-schedule intravesical gemcitabine with ablative intent in recurrent Ta-T1, G1-G2, low-or intermediate-risk, transitional cell carcinoma of the bladder. Eur Urol 2007;51:956-61. (Pubitemid 46281414)
80. Li D, Gan Y, Wientjes MG, Badalament RA, Au JL. Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: Cytochrome p450 oxidoreductase in bladder tissues and tumors. J Urol 2001;166:2500-5. (Pubitemid 33065343)
81. van der Heijden AG, Moonen PM, Cornel EB, Vergunst H, de Reijke TM, van Boven E, et al. Phase II marker lesion study with intravesical instillation of apaziquone for superficial bladder cancer: Toxicity and marker response. J Urol 2006;176:1349-53. (Pubitemid 44307194)