Fibrolase and its evolution to clinical trials: A long and winding road

Toxins and Hemostasis: From Bench to Bedside

Volumn , Issue , 2011, Pages 409-427

  Markland, Francis S ^a   Swenson, Stephen ^b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79960652099     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-9295-3_24     Document Type: Chapter

References (31)

1. Ahmed, N.K., Tennant, K.D., Markland, F.S., Lacz, J.P., 1990. Biochemical characteristics of fibrolase, a fibrinolytic protease from snake venom. Haemostasis 20, 147-154.
2. Bajwa, S.S., Kirakossian, H., Reddy, K.N., Markland, F.S., 1982. Thrombin-like and fibrinolytic enzymes in the venoms from the Gaboon viper (Bitis gabonica), eastern cottonmouth moccasin (Agkistrodon p. piscivorus) and southern copperhead (Agkistrodon c. contortrix) snakes. Toxicon 20, 427-432.
3. Bolger, M.B., Swenson, S., Markland, F.S., 2001. Three-dimensional structure of fibrolase, the fibrinolytic enzyme from southern copperhead venom, modeled from the X-ray structure of adamalysin II and atrolysin C. AAPS Pharm. Sci. 3, E16.
4. Burch, R.M., Farmer, S.G., Steranka, L.R., 1990. Bradykinin receptor antagonists. Med. Res. Rev. 10, 237-269.
5. Cummings-Winfield, C., Mushani-Kanji, T., 2008. Restoring patency to central venous access devices. Clin. J. Oncol. Nurs. 12, 925-934.
6. Deitcher, S.R., Funk, W.D., Buchanan, J., Liu, S., Levy, M.D., Toombs, C.F., 2006. Alfimeprase: A novel recombinant direct-acting fibrinolytic. Expert Opin. Biol. Ther. 6, 1361-1369.
7. Deitcher, S.R., Toombs, C.F., 2005. Non-clinical and clinical characterization of a novel acting thrombolytic: Alfimeprase. Pathophysiol. Haemost. Thromb. 34, 215-220.
8. Didisheim, P., Lewis, J.H., 1956. Fibrinolytic and coagulant activities of certain snake venoms and proteases. Proc. Soc. Exp. Biol. Med. 93, 10-13.
9. Guan, A.L., Retzios, A.D., Henderson, G.N., Markland, F.S., 1991. Purification and characterization of a fibrinolytic enzyme from venom of the southern copperhead snake (Agkistrodon contortrix contortrix). Arch. Biochem. Biophys. 289, 197-207.
10. Han, S.M., Weaver, F.A., Comerota, A.J., Perler, B.A., Joing, M., 2010. Efficacy and safety of alfimeprase in patients with acute peripheral arterial occlusion (PAO). J. Vasc. Surg. 51, 600-609.
11. Hong, T.T., Huang, J., Lucchesi, B.R., 2006. Effect of thrombolysis on myocardial injury: recombinant tissue plasminogen activator vs. alfimeprase. Am. J. Physiol. Heart Circ. Physiol. 290, H959-H967.
12. Kornalik, F., 1966. The influence of snake venoms on fibrinogen conversion and fibrinolysis.Mem. Inst. Butantan Simp. Int. 33, 179.
13. Lee, E.K., 2002. Alteplase use for prevention of central line occlusion in a preterm infant. Ann. Pharmacother. 36, 272-274.
14. Loayza, S.L., Trikha, M., Markland, F.S., Riquelme, P., Kuo, J., 1994. Resolution of isoforms of natural and recombinant fibrolase, the fibrinolytic enzyme from Agkistrodon contortrix contortrix snake venom, and comparison of their EDTA sensitivities. J. Chromatogr. B. Biomed. Appl. 662, 227-243.
15. Lu, A., Kurosawa, Y., Luskey, K., Pyne-Geithman, G., Caudell, D., Clark, J., 2009. Hemorrhagic profile of the fibrinolytic alfimeprase after ischemia and reperfusion. Neurol. Res. 31, 209-214.
16. Markland, F.S., Friedrichs, G.S., Pewitt, S.R., Lucchesi, B.R., 1994. Thrombolytic effects of recombinant fibrolase or APSAC in a canine model of carotid artery thrombosis. Circulation 90, 2448-2456.
17. Markland, F.S., Morris, S., Deschamps, J.R., Ward, K.B., 1993. Resolution of isoforms of natural and recombinant fibrinolytic snake venom enzyme using high performance capillary electrophoresis. J. Liquid Chromatog. 16, 2189-2201.
18. Markland, F.S., Reddy, K.N.N., Guan, L.F., 1988. Purification and characterization of a directacting fibrinolytic enzyme from southern copperhead venom, in: Pirkle, H., Markland, F.S. (Eds.), Hemostasis and Animal venoms (vol. 7). Marcel Dekker, New York, pp. 173-189.
19. Moise, M.A., Kashyap, V.S., 2008. Alfimeprase for the treatment of acute peripheral arterial occlusion. Expert Opin. Biol. Ther. 8, 683-689.
20. Moll, S., Kenyon, P., Bertoli, L., De Maio, J., Homesley, H., Deitcher, S.R., 2006. Phase II trial of alfimeprase, a novel-acting fibrin degradation agent, for occluded central venous access devices. J. Clin. Oncol. 24, 3056-3060.
21. No author, 2008. Alfimeprase. Drugs R D 9, 185-190.
22. Ouriel, K., Cynamon, J., Weaver, F.A., Dardik, H., Akers, D., Blebea, J., Gruneiro, L., Toombs, C.F., Wang-Clow, F., Mohler, M., Pena, L., Wan, C.Y., Deitcher, S.R., 2005. A phase I trial of alfimeprase for peripheral arterial thrombolysis. J. Vasc. Interv. Radiol. 16, 1075-1083.
23. Ouriel, K., Veith, F.J., Sasahara, A.A., 1996. Thrombolysis or peripheral arterial surgery: phase I results. TOPAS Investigators. J. Vasc. Surg. 23, 64-73.
24. Randolph, A., Chamberlain, S.H., Chu, H.L., Retzios, A.D., Markland, F.S., Masiarz, F.R., 1992. Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom. Protein Sci. 1, 590-600.
25. Rau, J.C., Beaulieu, L.M., Huntington, J.A., Church, F.C., 2007. Serpins in thrombosis, hemostasis and fibrinolysis. J. Thromb. Haemost. 5(Suppl 1), 102-115.
26. Reddy, G.K., 2006. Clinical utility of novel agents in the treatment of central venous catheter occlusion. Support Cancer Ther. 3, 135-139.
27. Retzios, A.D., Markland, F.S., 1990. HPLC-based two-step purification of fibrinolytic enzymes from the venom of Agkistrodon contortrix contortrix and Agkistrodon piscivorus conanti. Protein Expr. Purif. 1, 33-39.
28. Retzios, A.D., Markland, F.S., 1988. A direct-acting fibrinolytic enzyme from the venom of Agkistrodon contortrix contortrix: effects on various components of the human blood coagulation and fibrinolysis systems. Thromb. Res. 52, 541-52.
29. Swenson, S., Toombs, C.F., Pena, L., Johansson, J., Markland, F.S., 2004. Alpha-fibrinogenases. Curr. Drug. Targets Cardiovasc. Haematol. Disord. 4, 417-435.
30. Toombs, C.F., 2001. Alfimeprase: pharmacology of a novel fibrinolytic metalloproteinase for thrombolysis. Haemostasis 31, 141-147.
31. Trikha, M., Schmitmeier, S., Markland, F.S., 1994. Purification and characterization of fibrolase isoforms from venom of individual southern copperhead (Agkistrodon contortrix contortrix) snakes. Toxicon 32, 1521-1531.