Alfimeprase

Drugs in R and D

Volumn 9, Issue 3, 2008, Pages 185-190

[No Author Info available]

Author keywords

Alfimeprase, therapeutic use; Catheter thrombosis; Fibrinolytic agents, therapeutic use; Research and development; Stroke

Indexed keywords

ALFIMEPRASE; ALPHA 2 MACROGLOBULIN; FIBRINOLYTIC AGENT; FIBROLASE; PLACEBO;

BLEEDING; BLOOD CLOT LYSIS; CATHETER OCCLUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DEEP VEIN THROMBOSIS; DRUG DOSE ESCALATION; ENZYME MECHANISM; FIBRINOLYSIS; HEMATOMA; HISTORY OF MEDICINE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECOMBINANT DNA TECHNOLOGY; REVIEW; SNAKE; STROKE;

ARTERIAL OCCLUSIVE DISEASES; CLINICAL TRIALS AS TOPIC; DRUG DESIGN; FIBRINOLYTIC AGENTS; HUMANS; METALLOENDOPEPTIDASES;

EID: 43649107900     PISSN: 11745886     EISSN: None     Source Type: Journal    
DOI: 10.2165/00126839-200809030-00006     Document Type: Review

References (27)

1. Nuvelo Inc. Nuvelo Resumes Development of Alfimeprase in Multiple Blood-Clot Related Indications. Media Release: 26 Jun 2007. Available from URL: http://www.nuvelo.com
2. Nuvelo Inc. Nuvelo to Gain Worldwide Rights to Alfimeprase Through Amgen Licensing Agreement. Media Release: 1 Nov 2004. Available from URL: http://www.nuvelo.com
3. Nuvelo Inc. Nuvelo Reduces Expenses and Realigns Organization To Focus on Programs Expected To Yield Nearest-Term Proof-of-Concept Data. Media Release: 2 Aug 2007. Available from URL: http://www.nuvelo.com
4. Nuvelo Inc. Nuvelo and Bayer HealthCare Enter Comprehensive Collaboration Agreement to Maximize Global Development and Commercialization of Alfimeprase. Media Release: 5 Jan 2006. Available from URL: http://www.nuvelo.com
5. Nuvelo Inc. Nuvelo Announces Phase 2 SONOMA-3 Trial Did Not Meet Target Product Profile and Discontinues Alfimeprase Development. Media Release: 17 Mar 2008. Available from URL: http://www.nuvelo.com
6. Nuvelo Inc, Bayer HealthCare. Nuvelo and Bayer Healthcare Announce Phase 3 Trials of Alfimeprase in Patients With Acute Peripheral Arterial Occlusion and Catheter Occlusion Did Not Meet Primary Endpoints. Media Release: 12 Dec 2006. Available from URL: http://www.nuvelo.com. Summary in 2 parts (Part A)
7. Nuvelo Inc. Nuvelo Announces Results from Phase 3 NAPA Program in Acute Peripheral Arterial Occlusion. Media Release: 24 Jan 2008. Available from URL: http://www.nuvelo.com. Summary in 2 parts (Part A)
8. Nuvelo Inc. Nuvelo Announces Completion of Patient Enrollment in NAPA-2, First Phase 3 Trial of Alfimeprase in Acute Peripheral Arterial Occlusion. Media Release: 5 Sep 2006. Available from URL: http://www.nuvelo.com
9. Nuvelo Inc. Nuvelo Reports First Quarter 2006 Financial Results and Accomplishments. Media Release: 5 May 2006. Available from URL: http://www.nuvelo.com
10. Nuvelo Inc. Nuvelo and Bayer Healthcare Begin NAPA-3, Second Pivotal Phase 3 Trial of Alfimeprase for Acute Peripheral Arterial Occlusion. Media Release: 10 Apr 2006. Available from URL: http://www.nuvelo.com
11. Novel Arterial Perfusion with Alfimeprase (NAPA) Investigators. Alfimeprase, a novel direct-acting fibrinolytic agent in acute peripheral arterial occlusion: report of a phase 2, multicenter, open-label, dose-defining study. Circulation 114 (Suppl.): 648 (plus poster) abstr. 2777, No. 18, 31 Oct 2006
12. Nuvelo Inc. Nuvelo Announces the Completion of Its Phase 2 Alfimeprase Trial in Acute Peripheral Arterial Occlusion. Media Release: 28 Jun 2004. Available from URL: http://www.nuvelo.com
13. Nuvelo Inc. Nuvelo Phase 2 Clinical Trial Results Show Potential of Alfimeprase to Treat Acute Peripheral Arterial Occlusion, Also Known as ?Leg Attack?. Media Release: 30 Sep 2004. Available from URL: http://www.nuvelo.com
14. Nuvelo Inc. Nuvelo Announces Successful Results in Phase I Clinical Trial. Media Release: 27 Mar 2003. Available from URL: http://www.nuvelo.com
15. Nuvelo Inc. Nuvelo Announces Completion of Patient Enrollment in SONOMA-2, First Phase 3 Trial of Alfimeprase in Central Venous Catheter Occlusion. Media Release: 5 Sep 2006. Available from URL: http://www.nuvelo.com
16. Nuvelo Inc, Bayer HealthCare. Nuvelo and Bayer HealthCare Begin SONOMA-3, Second Phase 3 Trial of Alfimeprase in Patients With Central Venous Catheter Occlusion. Media Release: 27 Feb 2006. Available from URL: http://www.nuvelo.com
17. Nuvelo Inc. Nuvelo Reports Third Quarter 2005 Financial Results and Accomplishments. Media Release: 1 Nov 2005. Available from URL: http://www.nuvelo.com
18. Nuvelo Inc. Nuvelo Begins Phase 3 Program Evaluating Alfimeprase in Patients With Central Venous Catheter Occlusion. Media Release: 6 Sep 2005. Available from URL: http://www.nuvelo.com
19. Nuvelo Inc. Nuvelo Announces Design of Phase 3 Alfimeprase Program in Patients With Central Venous Catheter Occlusion. Media Release: 26 May 2005. Available from URL: http://www.nuvelo.com. Summary in 2 parts (Part A)
20. Nuvelo Inc. Nuvelo Provides 2006 Clinical Guidance at JPMorgan Conference. Media Release: 9 Jan 2006. Available from URL: http://www.nuvelo.com
21. Nuvelo Inc. Nuvelo Announces Publication of Phase 2 Alfimeprase Study Results in Central Venous Catheter Occlusion. Media Release: 6 Jul 2006. Available from URL: http://www.nuvelo.com
22. Nuvelo Inc. Nuvelo Reports Successful Completion of Interim Analysis in Phase 2 Trial With Alfimeprase in Catheter Occlusion. Media Release: 8 Jun 2004. Available from URL: http://www.nuvelo.com
23. Nuvelo Inc. Nuvelo Announces Strategy to Accelerate Catheter Occlusion Program. Media Release: 12 Jul 2004. Available from URL: http://www.nuvelo.com
24. Nuvelo Inc. Nuvelo Initiates Phase II Clinical Trial in Catheter Occlusion. Media Release: 5 Jun 2003. Available from URL: http://www.nuvelo.com
25. Nuvelo Inc. Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke. Media Release: 12 Dec 2007. Available from URL: http://www.nuvelo.com
26. Moll S, Gabrail N, Buchanan J, et al. Safety and efficacy of alfimeprase in subjects with occluded central venous access devices: the SONOMA-2 study. Blood 110: 552-553 (plus poster) abstr. 1866, No. 11, Part 1, Nov 2007
27. Nuvelo Inc. Nuvelo Announces Publication of Alfimeprase Phase 1 Clinical Trial Results. Media Release: 8 Aug 2005. Available from URL: http://www.nuvelo.com