Refining the eosinophil cationic protein antibacterial pharmacophore by rational structure minimization

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 5237-5244

  Torrent, Marc ^a,b   Pulido, David ^a   De La Torre, Beatriz G ^b   García Mayoral, M Flor ^c   Nogués, M Victòria ^a   Bruix, Marta ^c   Andreu, David ^b   Boix, Ester ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOCAPROIC ACID; ANTIINFECTIVE AGENT; EOSINOPHIL CATIONIC PROTEIN; LIPOPOLYSACCHARIDE BINDING PROTEIN;

ALPHA HELIX; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIUM AGGLUTINATION; DRUG POTENCY; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHARMACOPHORE; RATIONAL STRUCTURE MINIMIZATION; STRUCTURE ANALYSIS;

AGGLUTINATION; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; EOSINOPHIL CATIONIC PROTEIN; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HEMOLYSIS; HUMANS; LIPOPOLYSACCHARIDES; LIPOSOMES; MAGNETIC RESONANCE SPECTROSCOPY; MICELLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960648548     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200701g     Document Type: Article

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