Biochemical and morphological changes associated with macrophages and osteoclasts when challenged with infection

Biomedical Sciences Instrumentation

Volumn 47, Issue , 2011, Pages 183-188

  Wiggers, Erin Callie ^a   Johnson, William ^a   Tucci, Michelle ^a   Benghuzzi, Hamed ^a  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Macrophage; Osteoclast; Osteomyelitis; Rankl; Staphylococcus aureus

Indexed keywords

ANIMAL MODEL; BACTERIAL INFECTIONS; BIOCHEMICAL PATHWAY; CELL DAMAGE; CELL TYPES; CYTOKINES; DATA SUPPORT; IMMUNE RESPONSE; LIPOPOLYSACCHARIDES; MACROPHAGE CELL LINE; MORPHOLOGICAL CHANGES; ORTHOPEDIC SURGERY; OSTEOCLAST; OSTEOLYSIS; OSTEOMYELITIS; RANKL; RECEPTOR ACTIVATOR; RESPONSE MAGNITUDE; S. AUREUS; SKELETAL SYSTEM; STAPHYLOCOCCUS AUREUS; TISSUE DAMAGE;

BACTERIA; CELL CULTURE; NITRIC OXIDE; SURGERY; TISSUE;

MACROPHAGES;

GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MALONALDEHYDE; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL GROWTH; CELL LEVEL; CELL PROLIFERATION; CELLULAR IMMUNITY; COLOR; CONTROLLED STUDY; CYTOKINE RELEASE; MACROPHAGE; NONHUMAN; OPSONIZATION; OSTEOCLAST; STAPHYLOCOCCUS INFECTION;

EID: 79960642437     PISSN: 00678856     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Albright, L. M., F. M. Ausubel, R. Brent, D. M. Coen, K. (eds.). Janssen, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, K. Struhl, and A. Varki. Current Protocols in Molecular Biology. Vol. 1-2. New York, NY: John Wiley and Sons, 1994.
2. Allen, T. C. Hematoxylin and Eosin. Laboratory Methods in Histotechnology, American Registry of Pathology, Washington, D.C. (1992): 53-58.
3. Athanasou, N. A., J. Quinn, and C. J. K. Bulstrode. Resorption of bone by inflammatory cells derived from the joint capsule of hip arthroplasties. Journal of Bone and Joint Surgery 74 (1992a): 57-62.
4. Athanasou, N. A., J. I. Alvarez, F. P. Ross, J. M. Quinn, and S. L. Teitelbaum. Species differences in the immunophenotype of osteoclasts and mononuclear phagocytes. Calcified Tissue International 50 (1992b): 427-32.
5. Boyle, W. J., W. S. Simonet, and D. L. Lacey. Osteoclast differentiation and activation. Nature 423 (2003): 337-42.
6. Chen, X., D. T. Tsukayama, L. S. Kidder, C. A. Bourgeault, A. H. Schmidt, W. D. Lew. Characterization of a chronic infection in an internally-stabilized segmental defect in the rat femur. Journal of Orthopaedic Research 23.4 (2006): 816-823.
7. Ciampolini, J., and K. G. Harding. Pathophysiology of chronic bacterial osteomyelitis. Why do antibiotics fail so often? Postgraduate Medical Journal 76 (2000): 479-83.
8. Costerton, J. W., P. S. Stewart, and E. P. Greenberg. Bacterial Biofilms: a Common Cause of Persistant Infections. Science 284 (1999): 1318-322.
9. Ghosh, S., M.J. May, and E.B. Kopp. "NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses." Annu. Rev. Immunol. 16 (1998):225-260.
10. Holness, C. L., and D. L. Simmons. Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 81.6 (1993): 1607-613.
11. Junqueira, L. C., and J. Carneiro. Basic Histology Text & Atlas (Basic Histology). New York: McGraw-Hill Medical, 2005.
12. Khosla, S. Minireview: The OPG/RANKL/RANK System. Endocrinology 124.12 (2001): 5050-055.
13. Matsusaka, T., K Fujikawa, Y. Nishio, N. Mukaida, K. Matsushima, T. Kishimoto, and S Akira. Transcription factors NF-IL6 and NF-KB synergistically activate. Proceedings of the National Academy of Science 90 (1993): 10193-10197.
14. Meng, F., and C. A. Lowell. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Srcfamily kinases Hck, Fgr, and Lyn. Journal of Experimental Medicine 185.9 (1997): 1661-670.
15. Murray, P. R., et al. Manual of clinical microbiology. Washington, D.C: American Society for Microbiology, 2003.
16. Newman, S. L., and M. A. Tucci. Regulation of human monocyte/macrophage function by extracellular matrix. Journal of Clinical Investigation (1990).
17. Rahimi, P., C. Y. Wang, P. Stashenko, S. K. Lee, J. A. Lorenzo, and D. T. Graves. Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse. Endocrinology 136.6 (1995): 2752-759.
18. Rho, J., M. Takami, and Y. Choi. Osteoimmunology: Interactions of the Immune and Skeletal Systems. Molecules and Cells 17.1 (2004): 1-9.
19. Takayanagi, H. Osteoimmunology: shared mechanisms and cross talk between the immune and bone systems. Nature Reviews: Immunology 7 (2007): 292-304.
20. Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289 (2000): 1504-508.
21. Tsukayama, D. T. Pathophysiology of posttraumatic osteomyelitis. Clinical Orthopaedics and Related Research 360 (1999): 22-29.
22. Vincent, C., M. Kogawa, D. M. Findlay, and G. J. Atkins. The generation of osteoclasts from RAW 264.7 precursors in defined, serum-free conditions. Journal of Bone and Mineral Metabolism 27 (2009): 114-19.