Corneal damage induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea

In Vivo

Volumn 25, Issue 4, 2011, Pages 609-615

  Yoshizawa, Katsuhiko ^a   Sasaki, Tomo ^a,b   Kuro, Maki ^a   Miki, Hisanori ^a   Kimura, Ayako ^a   Uehara, Norihisa ^a   Yuri, Takashi ^a   Tsubura, Airo ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b Maruho Co   (Japan)

Author keywords

Corneal damage; Corneal epithelial cell; N ethyl N nitrosourea; p63; PCNA

Indexed keywords

ETHYLNITROSOUREA; PROTEIN P63;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL KINETICS; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; CORNEA DISEASE; CORNEA EPITHELIUM; CORNEA EROSION; CORNEA THICKNESS; CORNEAL ENDOTHELIAL CELL LOSS; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MOUSE; NICK END LABELING; NONHUMAN;

EID: 79960634581     PISSN: 0258851X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Li J, Tripathi RC and Tripathi BJ: Drug-induced ocular disorders. Drug Saf 31: 127-141, 2008.
2. Basu PK: Toxic effects of drugs on the corneal epithelium: a review. Cut Ocular Toxicol 2: 205-227, 1983.
3. Cruciani F, Tamanti N, Abdolrahimzadeh S, Franchi F and Gabrieli CB: Ocular toxicity of systemic chemotherapy with megadoses of carmustine and mitomycin. Ann Ophthalmol 26: 97-100, 1994.
4. AL-Tweigeri T, Nabholtz JM and Mackey JR: Ocular toxicity and cancer chemotherapy. Cancer 78: 1359-1373, 1996.
5. Omoti AE and Omoti CE: Ocular toxicity of systemic anticancer chemotherapy. Pharmacy Practice 4: 55-59, 2006. (Pubitemid 44489374)
6. Guthoff T, Tietze B, Meinhardt B, Becher J and Guthoff R: Cytosine-arabinoside-induced keratopathy: a model of corneal proliferation kinetics. Ophthalmologica 224: 308-311, 2010.
7. Kashiwagi H: Ocular disorders of anticancer drugs - ocular side-effects. Jpn J Cancer Chemother 37: 1639-1644, 2010 (in Japanese, English abstract).
8. Shapiro MS, Thaft RA, Friend J, Parrish RK and Gressel MG: 5-Fluorouracil toxicity to the ocular surface epithelium. Invest Ophthalmol Vis Sci 26: 580-583, 1985.
9. Hollander DA and Aldave AJ: Drug-induced corneal complications. Curr Opin Ophthalmol 15: 541-548, 2004.
10. Gnewuch CT and Sosnovsky G: A critical appraisal of the evolution of N-nitrosoureas as anticancer drugs. Chem Rev 97: 829-1013, 1997. (Pubitemid 127661200)
11. World Health Organization, International Agency for Research on Cancer (WHO IARC): N-Nitroso-N-ethylurea. In: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 17, Some N-Nitroso Compounds. Lyon, IARC Scientific Publications, p. 191, 1998.
12. Guttenplan JB: Mutagenesis by N-nitroso compounds: relationships to DNA adducts, DNA repair, and mutational efficiencies. Mut Res 233: 177-187, 1990.
13. Probst FJ and Justice MJ: Mouse mutagenesis with the chemical supermutagen ENU. Meth Enzymol 15: 297-312, 2010.
14. Favor J and Neuhauser-Klaus A: Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus. Mamm Genome 11: 520-525, 2000. (Pubitemid 30602216)
15. 2G257D mutant mouse. Invest Ophthalmol Vis Sci 50: 5653-5661, 2009.
16. Wagner S, Calzada-Wack J, Rosemann M, Becher L, Tost M, Silva-Buttkus P, Klein-Rodewald T, Fuchs H, Neff F, Hrabe de Angelis M and Esposito I: Characterization of ENU-mutant mice. Animal models for human diseases using morphological and molecular methods. Pathologie Suppl 2: 147-152, 2010.
17. Yoshizawa K, Kuro-Kuwata M, Sasaki T, Lai C, Kanematsu S, Miki H, Kimura-Kawanaka A, Uehara N, Yuri T and Tsubura A: Retinal degeneration induced in adult mice by a single intraperitoneal injection of N-ethyl-N-nitrosourea. Toxicol Pathol 39: 2011 (In press).
18. Park SA, Jeong SM, Yi NY, Kim MS, Jeong MB, Suh JG, Oh YS, Won MH, Nam TC, Park JH and Seo KM: Study on the ophthalmic diseases in ICR mice and BALB/c mice. Exp Anim 55: 83-90, 2006.
19. Smith RS, Sundberg JP and John SW: Regional anatomy and development. The anterior segment and ocular adnexae. In: Systemic Evaluation of the Mouse Eye, Anatomy, Pathology, and Biomethods. Smith RS (ed.). New York, CRC Press, pp. 3-23, 2002.
20. Yoshizawa K, Oishi Y, Sano K, Tsubota K, Ikeda K, Fukuhara Y, Senzaki H and Tsubura A: Hepatocellular carcinoma with PIVKA-II production in a young laboratory monkey. J Toxicol Pathol 15: 61-68, 2002.
21. Gan L, van Setten G, Seregard S and Fagerholm P: Proliferating cell nuclear antigen colocalization with corneal epithelial stem cells and involvement in physiological cell turnover. Acta Ophthalmol Scand 73: 491-495, 1995. (Pubitemid 26059858)
22. Hsueh YJ, Wang DY, Cheng CC and Chen JK: Age-related expressions of p63 and other keratinocyte stem cell markers in rat cornea. J Biomed Sci 11: 641-651, 2004.
23. Pajoohesh-Ganji A and Stepp MA: In search of markers for the stem cells of the corneal epithelium. Biol Cell 97: 265-276, 2005.
24. Pellegrini G, Rama P, Mavilio F and Luca MD: Epithelial stem cells on corneal regeneration and epidermal gene therapy. J Pathol 217: 217-228, 2009.
25. Ehlers N and Hjortdal J: The cornea, epithelium and stroma. Adv Organ Biol 10: 83-111, 2006.
26. Elgjo K: Cell renewal of the normal mouse cornea. Acta Pathol Microbiol Scand 76: 25-30, 1969.
27. Cenedella RJ and Fleschner CR: Kinetics of corneal epithelium turnover in vivo. Invest Ophthalmol Vis Sci 31: 1957-1962, 1990.
28. Mallick KS, Hajek AS and Parrish RK: Fluorouracil (5-FU) and cytarabine (ara-C) inhibition of corneal epithelial cell and conjunctival fibroblast proliferation. Arch Ophthalmol 103: 1398-1402, 1985. (Pubitemid 15230636)
29. Whiteley HE and Peiffer RL: The eye. In: Handbook of Toxicologic Pathology, 2nd ed, Vol. 2. Haschek WM, Rousseaux CG and Walling MA (eds.). San Diego, Academic Press, pp. 539-583, 1991.
30. Doak SH, Jenkins GJS, Johnson GE, Quick E, Parry EM and Parry JM: Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens. Cancer Res 67: 3904-3911, 2007. (Pubitemid 46762179)
31. Yoshizawa K, Nambu H, Yang J, Oishi Y, Senzaki H, Shikata N, Miki H and Tsubura A: Mechanisms of photoreceptor cell apoptosis induced by N-methyl-N-nitrosourea in Sprague-Dawley rats. Lab Invest 79: 1359-1367, 1999.
32. Yoshizawa K and Tsubura A: Characteristics of N-methyl-N-nitrosourea- induced retinal degeneration in animals and application for the therapy of human retinitis pigmentosa. Nippon Ganka Gakkai Zasshi 109: 327-337, 2005 (in Japanese, English abstract).