Central (ICV) leptin injection increases bone formation, bone mineral density, muscle mass, serum IGF-1, and the expression of osteogenic genes in leptin-deficient ob/ob mice

Journal of Bone and Mineral Research

Volumn 26, Issue 8, 2011, Pages 1710-1720

  Bartell, Shoshana M ^a   Rayalam, Srujana ^a   Ambati, Suresh ^a   Gaddam, Dhanunjaya R ^a   Hartzell, Diane L ^a   Hamrick, Mark ^c   She, Jin Xiong ^c   Della Fera, Mary Anne ^a   Baile, Clifton A ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

bone; gene expression; leptin; OB OB mice; osteoporosis

Indexed keywords

INSULIN; LIPID; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PYRIDINOLINE; RECOMBINANT LEPTIN; SOMATOMEDIN C;

ADIPOCYTE; ADIPOGENESIS; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BODY FAT; BONE DENSITY; BONE DEVELOPMENT; BONE GROWTH; BONE MARROW; BONE METABOLISM; CELL DIFFERENTIATION; CELL MATURATION; CONTROLLED STUDY; FEMALE; FOOD INTAKE; GENE EXPRESSION; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID STORAGE; LIPID TRANSPORT; MOUSE; MUSCLE MASS; NONHUMAN; OBESITY; OSSIFICATION; OSTEOCLASTOGENESIS; THERMOGENESIS; WEIGHT REDUCTION;

ADIPOCYTES; ANIMALS; BODY WEIGHT; BONE DENSITY; BONE MARROW; CELL COUNT; FEEDING BEHAVIOR; FEMALE; FEMUR; GENE EXPRESSION REGULATION; INJECTIONS, INTRAVENTRICULAR; INSULIN-LIKE GROWTH FACTOR I; LEPTIN; MICE; MICE, INBRED C57BL; MICE, OBESE; MUSCLES; ORGAN SIZE; OSTEOGENESIS; TIBIA;

EID: 79960629585     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.406     Document Type: Article

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