Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 78, Issue 3, 2011, Pages 377-384

  Maximiano, Flávia Pires ^a   De Paula, Lívia Maria ^a   Figueiredo, Vivian Paulino ^a   De Andrade, Isabel Mayer ^a   Talvani, André ^a   Sá Barreto, Lívia C ^b   Bahia, Maria Terezinha ^a   Cunha Filho, Marcílio S S ^b  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

^b FEDERAL UNIVERSITY OF MATO GROSSO   (Brazil)

Author keywords

Benznidazole; Chagas disease; Dissolution rate; Microcrystals; Solvent change precipitation

Indexed keywords

BENZNIDAZOLE; SOLVENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHAGAS DISEASE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYSTAL; DIFFERENTIAL SCANNING CALORIMETRY; DRUG EFFICACY; DRUG SOLUBILITY; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PARTICLE SIZE; PRECIPITATION; SCANNING ELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CHAGAS DISEASE; CHEMICAL PRECIPITATION; DISEASE MODELS, ANIMAL; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; EXCIPIENTS; FEMALE; HARDNESS TESTS; METHYLCELLULOSE; MICE; NITROIMIDAZOLES; POLYMERS; SOLUBILITY; SOLVENTS; TABLETS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 79960609392     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.03.003     Document Type: Article

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