Development of parenteral formulations and evaluation of the biological activity of the trypanocide drug benznidazole

International Journal of Pharmaceutics

Volumn 307, Issue 2, 2006, Pages 239-243

  Lamas, María C ^a   Villaggi, Luciano ^b   Nocito, Isabel ^b   Bassani, Georgina ^a   Leonardi, Darío ^a   Pascutti, Fernanda ^b   Serra, Esteban ^b   Salomón, Claudio J ^a,c  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

^b Instituto de Biologia Molecular y Celular de Rosario   (Argentina)

^c Universidad Nacional de Rosario   (Argentina)

Author keywords

Benznidazole; Chagas disease; Cosolvent systems; Parenteral formulation; Water solubility

Indexed keywords

ALCOHOL; ANTITRYPANOSOMAL AGENT; BENZNIDAZOLE; BENZYL ALCOHOL; BUFFER; DIETHYLENE GLYCOL MONOETHYL ETHER; DOCUSATE SODIUM; DRUG VEHICLE; MACROGOL 400; POLYSORBATE 40; POLYSORBATE 80; POTASSIUM BIPHTHALATE; SOLVENT; SURFACTANT; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; BIOASSAY; BIOLOGICAL ACTIVITY; DRUG FORMULATION; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; MOUSE; NONHUMAN; PARASITE; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RELIABILITY; REPRODUCIBILITY; SOLUBILIZATION; TOXICITY;

ANIMALS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DIOCTYL SULFOSUCCINIC ACID; DRUG STABILITY; ETHANOL; NITROIMIDAZOLES; PARASITIC SENSITIVITY TESTS; PHTHALIC ACIDS; POLYETHYLENE GLYCOLS; POLYSORBATES; SOLVENTS; SURFACE-ACTIVE AGENTS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 29244486191     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2005.10.004     Document Type: Article

References (22)

1. S. Agrawal, N. Pnacholi, and G. Agrawal Hydrotropic solubilization of nimesulide for parenteral administration Int. J. Pharm. 274 2004 149 155
2. P.J.S. Barbeira, G.M. Silva, M.P.M. Beatriz, and N.R. Stradiotto Polarographic determination of benznidazole in DMSO J. Pharm. Biomed. Anal. 20 1999 723 726
3. E.P. Camargo Growth and differentiation in Trypanosoma cruzi. I. Origin of metacyclic trypanosomes in liquid medium Rev. Med. Trop. Sao Paulo 6 1964 220 224
4. P. Constantinides, A. Tustian, and D.R. Kessler Tocol emulsions for drug solubilization and parenteral delivery Adv. Drug Deliv. Rev. 56 2004 1243 1255
5. M. Cuellar, C. Salas, M. Cortes, A. Morello, J. Maya, and M. Preite Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives Bioorg. Med. Chem. 11 2003 2489 2497
6. M.A. Etman, and A.H. Nada Hydrotropic and cosolvent solubilisation of indomethacin Acta Pharm. 49 1999 291 298
7. N.A. Kasim, M. Whitehouse, C. Ramachandran, M. Bermejo, H. Lennernäs, A.S. Hussain, H.E. Junginger, S.A. Stavchansky, K.K. Midha, V.P. Shah, and G.L. Amidon Molecular properties of WHO essential drugs and provisional biopharmaceutical classification Mol. Pharm. 1 2004 85 96
8. C-K. Kim, and J-S. Park Solubility enhancers for oral drug delivery: can chemical structure manipulation be avoided? Am. J. Drug Deliv. 2 2004 113 130
9. J. Molina, J. Urbina, R. Gref, Z. Brener, and J.M. Rodrigues Cure of experimental Chagas' disease by the bis-triazole DO870 incorporated into stealth polyethyleneglycol-polylactide nanospheres J. Antimicrob. Chem. 47 2001 101 104
10. C.M. Morel Reaching maturity - 25 years of the TDR Parasitol. Today 16 2000 522 525
11. M.J. Morilla, P. Benavidez, M.O. Lopez, L. Bakas, and E.L. Romero Development and in vitro characterization of a benznidazole liposomal formulation Int. J. Pharm. 249 2002 89 99
12. M.J. Morilla, J.A. Montanari, M.J. Prieto, M.O. Lopez, P.B. Petray, and E.L. Romero Intravenous liposomal benznidazole as trypanocidal agent: increasing drug delivery to liver is not enough Int. J. Pharm. 278 2004 311 318
13. S. Murta, R. Gazzinelli, Z. Brener, and A. Romanha Molecular characterization of susceptible and naturally resistant strains of Trypanosoma cruzi to benznidazole and nifurtimox Mol. Biochem. Parasitol. 93 1998 203 214
14. N. Ni, T. Sanghvi, and S.H. Yalkowsky Solubilization and preformulation of carbendazim Int. J. Pharm. 244 2002 99 104
15. Y. Ran, and S.H. Yalkowsky Halothane, a novel solvent for the preparation of liposomes containing 2-4′-amino-3′-methylphenyl benzothiazole (AMPB), an anticancer drug: a technical note AAPS PharmSciTech 4 2003 1 5
16. E. Rytting, K.A. Lentz, X-Q. Chen, F. Qian, and S. Venkatesh A quantitative structure-property relationship for predicting drug solubility in PEG 400/water cosolvent systems Pharm. Res. 21 2004 237 244
17. A.J. Spiegel, and M.M. Noseworthy Use of non-aqueous solvents in parenteral products J. Pharm. Sci. 52 1963 917 927
18. V.J. Stella, H. Lee, and D. Thomsom The effect of SBE4-ß-CD on i.v. methylprednisolone pharmacokinetics in rats: comparison to a co-solvent solution and two water-soluble prodrugs Int. J. Pharm. 120 1995 189 195
19. S. Torrado, M.L. López, G. Torrado, F. Bolás, S. Torrado, and R. Cadórniga A novel formulation of albendazole solution: oral bioavailability and efficacy evaluation Int. J. Pharm. 156 1997 181 187
20. J. Urbina, and R. Docampo Specific chemotherapy of Chagas disease: controversies and advances Trends Parasitol. 19 2003 495 501
21. S.H. Yalkowsky, and T.J. Roseman Solubilization of drugs by cosolvents Techniques of Solubilization of Drugs 1981 Dekker New York, NY
22. World Health Organization Control of Chagas disease Tech. Rep. Ser. 905 2002 1 109