Effects of early IL-17A neutralization on disease induction in a primate model of experimental autoimmune encephalomyelitis

Journal of Neuroimmune Pharmacology

Volumn 6, Issue 3, 2011, Pages 341-353

  Kap, Yolanda S ^a,b   Jagessar, S Anwar ^a,b   Van Driel, Nikki ^a   Blezer, Erwin ^c   Bauer, Jan ^d   Van Meurs, Marjan ^b   Smith, Paul ^a   Laman, Jon D ^b   T'Hart, Bert A ^a,b  

^a BIOMEDICAL PRIMATE RESEARCH CENTRE   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

Antibody therapy; IL 23; Neuroimmunology; Non human primate; Th17

Indexed keywords

INTERLEUKIN 17; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY INTERLEUKIN 17A; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PLACEBO; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALLITRICHINAE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DEMYELINATION; DISEASE COURSE; FEMALE; HAPLORHINI; INFLAMMATION; LYMPH NODE; LYMPHOCYTE PROLIFERATION; LYMPHOID ORGAN; MALE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; T LYMPHOCYTE; TREATMENT RESPONSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; CALLITHRIX; CELL PROLIFERATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; MALE; MYELIN-ASSOCIATED GLYCOPROTEIN; T-LYMPHOCYTES;

EID: 79960571981     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-010-9238-3     Document Type: Article

References (37)

1. RC Axtell BA de Jong K Boniface LF van der Voort R Bhat P De Sarno R Naves M Han F Zhong JG Castellanos R Mair A Christakos I Kolkowitz L Katz J Killestein CH Polman MR de Waal L Steinman C Raman 2010 T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis Nat Med 16 406 412 20348925 10.1038/nm.2110 1:CAS:528:DC%2BC3cXjvFWjsL4%3D
2. B Becher BG Durell RJ Noelle 2002 Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12 J Clin Invest 110 493 497 12189243 1:CAS:528:DC%2BD38XmsVSiurc%3D (Pubitemid 34919703)
3. A Billiau P Matthys 2001 Modes of action of Freund's adjuvants in experimental models of autoimmune diseases J Leukoc Biol 70 849 860 11739546 1:CAS:528:DC%2BD3MXpt1Sjt7g%3D (Pubitemid 33151123)
4. EL Blezer J Bauer HP Brok K Nicolay BA 't Hart 2007 Quantitative MRI-pathology correlations of brain white matter lesions developing in a non-human primate model of multiple sclerosis NMR Biomed 20 90 103 16948176 10.1002/nbm.1085 (Pubitemid 46470931)
5. L Boon HP Brok J Bauer A Ortiz-Buijsse MM Schellekens S Ramdien-Murli E Blezer M van Meurs J Ceuppens M de Boer BA 't Hart JD Laman 2001 Prevention of experimental autoimmune encephalomyelitis in the common marmoset (Callithrix jacchus) using a chimeric antagonist monoclonal antibody against human CD40 is associated with altered B cell responses J Immunol 167 2942 2949 11509643 1:CAS:528:DC%2BD3MXmtlSju74%3D (Pubitemid 32768930)
6. HP Brok A Uccelli N Kerlero De Rosbo RE Bontrop L Roccatagliata NG de Groot E Capello JD Laman K Nicolay GL Mancardi A Ben-Nun BA 't Hart 2000 Myelin/oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis in common marmosets: the encephalitogenic T cell epitope pMOG24-36 is presented by a monomorphic MHC class II molecule J Immunol 165 1093 1101 10878388 1:CAS:528:DC%2BD3cXkvFWitL8%3D (Pubitemid 30484781)
7. HP Brok M van Meurs E Blezer A Schantz D Peritt G Treacy JD Laman J Bauer BA 't Hart 2002 Prevention of experimental autoimmune encephalomyelitis in common marmosets using an anti-IL-12p40 monoclonal antibody J Immunol 169 6554 6563 12444167 1:CAS:528:DC%2BD38Xpt1Klsb4%3D (Pubitemid 36903508)
8. Y Chen CL Langrish B McKenzie B Joyce-Shaikh JS Stumhofer T McClanahan W Blumenschein T Churakovsa J Low L Presta CA Hunter RA Kastelein DJ Cua 2006 Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis J Clin Invest 116 1317 1326 16670771 10.1172/JCI25308 1:CAS:528:DC%2BD28XksVWns7w%3D
9. A Compston A Coles 2008 Multiple sclerosis Lancet 372 1502 1517 18970977 10.1016/S0140-6736(08)61620-7 1:CAS:528:DC%2BD1cXht12gtLvN
10. DJ Cua J Sherlock Y Chen CA Murphy B Joyce B Seymour L Lucian W To S Kwan T Churakova S Zurawski M Wiekowski SA Lira D Gorman RA Kastelein JD Sedgwick 2003 Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain Nature 421 744 748 12610626 10.1038/nature01355 1:CAS:528:DC%2BD3sXhsV2rsbs%3D (Pubitemid 36227625)
11. LA Fouser JF Wright K Dunussi-Joannopoulos M Collins 2008 Th17 cytokines and their emerging roles in inflammation and autoimmunity Immunol Rev 226 87 102 19161418 10.1111/j.1600-065X.2008.00712.x 1:CAS:528:DC%2BD1MXhsFGls77J
12. CP Genain MH Nguyen NL Letvin R Pearl RL Davis M Adelman MB Lees C Linington SL Hauser 1995 Antibody facilitation of multiple sclerosis-like lesions in a nonhuman primate J Clin Invest 96 2966 2974 8675668 10.1172/JCI118368 1:CAS:528:DyaK28XmtVemsg%3D%3D
13. B Gran GX Zhang S Yu J Li XH Chen ES Ventura M Kamoun A Rostami 2002 IL-12p35-deficient mice are susceptible to experimental autoimmune encephalomyelitis: evidence for redundancy in the IL-12 system in the induction of central nervous system autoimmune demyelination J Immunol 169 7104 7110 12471147 1:CAS:528:DC%2BD38XpsFGjtr8%3D (Pubitemid 36899299)
14. S Haak AL Croxford K Kreymborg FL Heppner S Pouly B Becher A Waisman 2009 IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice J Clin Invest 119 61 69 19075395 1:CAS:528:DC%2BD1MXmtFChsw%3D%3D
15. HH Hofstetter SM Ibrahim D Koczan N Kruse A Weishaupt KV Toyka R Gold 2005 Therapeutic efficacy of IL-17 neutralization in murine experimental autoimmune encephalomyelitis Cell Immunol 237 123 130 16386239 10.1016/j.cellimm.2005.11.002 1:CAS:528:DC%2BD28Xls1ahsg%3D%3D (Pubitemid 43117208)
16. A Jager V Dardalhon RA Sobel E Bettelli VK Kuchroo 2009 Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes J Immunol 183 7169 7177 19890056 10.4049/jimmunol.0901906
17. SA Jagessar YS Kap N Heijmans N van Driel L van Straalen JJ Bajramovic HPM Brok ELA Blezer J Bauer JD Laman BA Hart 2010 Induction of progressive demyelinating autoimmune encephalomyelitis in common marmoset monkeys using MOG34-56 peptide in incomplete Freund adjuvant J Neuropathol Exp Neurol 69 372 385 20448482 10.1097/NEN.0b013e3181d5d053 1:CAS:528:DC%2BC3cXktFGmt78%3D
18. YS Kap P Smith SA Jagessar E Remarque E Blezer GJ Strijkers JD Laman RQ Hintzen J Bauer HP Brok BA 't Hart 2008 Fast progression of recombinant human myelin/oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis in marmosets is associated with the activation of MOG34-56-specific cytotoxic T cells J Immunol 180 1326 1337 18209026 1:CAS:528:DC%2BD1cXotlGisQ%3D%3D
19. YS Kap JD Laman BA 't Hart 2010 Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development J Neuroimmune Pharmacol 5 220 230 19826959 10.1007/s11481-009-9178-y
20. N Kerlero de Rosbo M Hoffman I Mendel I Yust J Kaye R Bakimer S Flechter O Abramsky R Milo A Karni A Ben-Nun 1997 Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions Eur J Immunol 27 3059 3069 9394837 10.1002/eji.1830271144 1:CAS:528:DyaK2sXnt1Ojt78%3D (Pubitemid 27478380)
21. Y Komiyama S Nakae T Matsuki A Nambu H Ishigame S Kakuta K Sudo Y Iwakura 2006 IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis J Immunol 177 566 573 16785554 1:CAS:528: DC%2BD28XlvV2ntbg%3D (Pubitemid 43939170)
22. MA Kroenke TJ Carlson AV Andjelkovic BM Segal 2008 IL-12- and IL-23-modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition J Exp Med 205 1535 1541 18573909 10.1084/jem.20080159 1:CAS:528:DC%2BD1cXosVKktrc%3D (Pubitemid 351962016)
23. JD Laman M van Meurs MM Schellekens M de Boer B Melchers L Massacesi H Lassmann E Claassen BA 't Hart 1998 Expression of accessory molecules and cytokines in acute EAE in marmoset monkeys (Callithrix jacchus) J Neuroimmunol 86 30 45 9655470 10.1016/S0165-5728(98)00024-1 1:CAS:528:DyaK1cXjsVensrs%3D (Pubitemid 28293947)
24. JD Laman BA 't Hart H Brok M Meurs MM Schellekens A Kasran L Boon J Bauer M Boer J Ceuppens 2002 Protection of marmoset monkeys against EAE by treatment with a murine antibody blocking CD40 (mu5D12) Eur J Immunol 32 2218 2228 12209634 10.1002/1521-4141(200208)32:8<2218::AID-IMMU2218>3.0.CO;2-0 1:CAS:528:DC%2BD38XmslSlt7c%3D (Pubitemid 34965884)
25. CL Langrish Y Chen WM Blumenschein J Mattson B Basham JD Sedgwick T McClanahan RA Kastelein DJ Cua 2005 IL-23 drives a pathogenic T cell population that induces autoimmune inflammation J Exp Med 201 233 240 15657292 10.1084/jem.20041257 1:CAS:528:DC%2BD2MXot12mtA%3D%3D (Pubitemid 40189432)
26. JR Lees Y Iwakura JH Russell 2008 Host T cells are the main producers of IL-17 within the central nervous system during initiation of experimental autoimmune encephalomyelitis induced by adoptive transfer of Th1 cell lines J Immunol 180 8066 8072 18523270 1:CAS:528:DC%2BD1cXntVels7g%3D
27. RA O'Connor CT Prendergast CA Sabatos CW Lau MD Leech DC Wraith SM Anderton 2008 Cutting edge: Th1 cells facilitate the entry of Th17 cells to the central nervous system during experimental autoimmune encephalomyelitis J Immunol 181 3750 3754 18768826
28. TA Rohn GT Jennings M Hernandez P Grest M Beck Y Zou M Kopf MF Bachmann 2006 Vaccination against IL-17 suppresses autoimmune arthritis and encephalomyelitis Eur J Immunol 36 2857 2867 17048275 10.1002/eji.200636658 1:CAS:528:DC%2BD28Xht1Ons7%2FM (Pubitemid 44782559)
29. E Smith MA Stark A Zarbock TL Burcin AC Bruce D Vaswani P Foley K Ley 2008 IL-17A inhibits the expansion of IL-17A-producing T cells in mice through "short-loop" inhibition via IL-17 receptor J Immunol 181 1357 1364 18606690 1:CAS:528:DC%2BD1cXotF2rt74%3D
30. M Sospedra R Martin 2005 Immunology of multiple sclerosis Annu Rev Immunol 23 683 747 15771584 10.1146/annurev.immunol.23.021704.115707 1:CAS:528:DC%2BD2MXktFOju7w%3D (Pubitemid 40563183)
31. BA 't Hart L Massacesi 2009 Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus) J Neuropathol Exp Neurol 68 341 355 19337065 10.1097/NEN.0b013e31819f1d24
32. BA 't Hart J Bauer HJ Muller B Melchers K Nicolay H Brok RE Bontrop H Lassmann L Massacesi 1998 Histopathological characterization of magnetic resonance imaging-detectable brain white matter lesions in a primate model of multiple sclerosis: a correlative study in the experimental autoimmune encephalomyelitis model in common marmosets (Callithrix jacchus) Am J Pathol 153 649 663 10.1016/S0002-9440(10)65606-4 (Pubitemid 28373674)
33. BA 't Hart JD Laman J Bauer E Blezer Y van Kooyk RQ Hintzen 2004 Modelling of multiple sclerosis: lessons learned in a non-human primate Lancet Neurol 3 588 597 15380155 10.1016/S1474-4422(04)00879-8 (Pubitemid 39232075)
34. BA 't Hart EL Blezer HP Brok L Boon M de Boer J Bauer JD Laman 2005 Treatment with chimeric anti-human CD40 antibody suppresses MRI-detectable inflammation and enlargement of pre-existing brain lesions in common marmosets affected by MOG-induced EAE J Neuroimmunol 163 31 39 15885306 10.1016/j.jneuroim.2005.02.005 (Pubitemid 40692947)
35. BA 't Hart HP Brok E Remarque J Benson G Treacy S Amor RQ Hintzen JD Laman J Bauer EL Blezer 2005 Suppression of ongoing disease in a nonhuman primate model of multiple sclerosis by a human-anti-human IL-12p40 antibody J Immunol 175 4761 4768 16177124 (Pubitemid 41362018)
36. BA 't Hart RQ Hintzen JD Laman 2008 Preclinical assessment of therapeutic antibodies against human CD40 and human interleukin-12/23p40 in a nonhuman primate model of multiple sclerosis Neurodegener Dis 5 38 52 18075274 10.1159/000109937 (Pubitemid 350261815)
37. C Uyttenhove J Van Snick 2006 Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis Eur J Immunol 36 2868 2874 17048276 10.1002/eji.200636662 1:CAS:528:DC%2BD28Xht1Ons7%2FO (Pubitemid 44782560)