Severe insulin resistance and moderate glomerulosclerosis in a minipig model induced by high-fat/high-sucrose/high-cholesterol diet

Experimental Animals

Volumn 56, Issue 1, 2007, Pages 11-20

  Liu, Yi ^a,b   Wang, Zongbao ^a   Yin, Weidong ^a   Li, Qinkai ^a   Cai, Manbo ^a   Zhang, Chi ^a   Xiao, Junxia ^a   Hou, Hongjie ^a   Li, Hongguang ^a   Zu, Xiuhong ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b SHAOGUAN UNIVERSITY   (China)

Author keywords

Diabetic nephropathy; Diabetogenic diet; Extracellular matrix; Minipig model; Type 2 diabetes

Indexed keywords

COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; GELATINASE A; GLUCOSE; SUCROSE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; BLOOD ANALYSIS; CHOLESTEROL DIET; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE MODEL; DISEASE SEVERITY; DYSLIPIDEMIA; EXTRACELLULAR MATRIX; GLOMERULOSCLEROSIS; GLUCOSURIA; HOMEOSTASIS; HYPERGLYCEMIA; HYPERINSULINEMIA; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; INSULIN RESPONSE; KIDNEY DISEASE; LIPID DIET; MALE; METABOLIC DISORDER; MICROALBUMINURIA; MINIPIG; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET CELL FUNCTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; URINALYSIS;

ANIMALS; CHOLESTEROL, DIETARY; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIETARY CARBOHYDRATES; DIETARY FATS; DISEASE MODELS, ANIMAL; EXTRACELLULAR MATRIX; HUMANS; INSULIN RESISTANCE; KIDNEY; MALE; SEVERITY OF ILLNESS INDEX; SUCROSE; SWINE; SWINE, MINIATURE;

EID: 33847676812     PISSN: 13411357     EISSN: None     Source Type: Journal    
DOI: 10.1538/expanim.56.11     Document Type: Article

References (20)

1. Bazzi, C., Petrini, C., Rizza, V., Arrigo, G., Napodano, P., Paparella, M., and D'Amico, G. 2002. Urinary N-acetyl-beta-glucosaminidase excretion is a marker of tubular cell dysfunction and a-predictor of outcome in primary glomerulonephritis. Nephrol. Dial. Transplant. 17: 1890-1896.
2. Bonora, E., Targher, G., Alberiche, M., Bonadonna, R.C., Saggiani, F., Zenere, M.B., Monauni, T., and Muggeo, M. 2000. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23: 57-63.
3. Fujimoto, W.Y. 2000. The importance of insulin resistance in the pathogenesis of type 2 diabetes mellitus. Am. J. Med. 108: 9S-14S.
4. Gross, J.L., de Azevedo, M.J., Silveiro, S.P., Canani, L.H., Caramori, M.L., and Zelmanovitz, T. 2005. Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 28: 164-176.
5. Huang, B.W., Chiang, M.T., Yao, H.T., and Chang, W. 2004. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes Obes. Metab. 6: 120-126.
6. Kasiske, B.L., O'Donnell, M.P., Schmitz, P.G., Kim, Y., and Keane, W.F. 1990. Renal injury of diet-induced hypercholesterolemia in rats. Kidney Int. 37: 880-891.
7. Kluwe, W.M. 1981. Rapid, automated measurements of urinary protein and glucose concentrations. J. Pharmacol. Methods 5: 235-240.
8. Larsen, M.O., Rolin, B., Wilken, M., Carr, R.D., and Svendsen, O. 2002. High-fat high-energy feeding impairs fasting glucose and increases fasting insulin levels in the Göttingen minipig: results from a pilot study. Ann. N.Y. Acad. Sci. 967: 414-423.
9. Mason, R.M. and Wahab, N.A. 2003. Extracellular matrix metabolism in diabetic nephropathy. J. Am. Soc. Nephrol. 14: 1358-1373.
10. Matrisian, L.M. 1990. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet. 6: 121-125.
11. Nathan, D.M., Rosenbaum, C., and Protasowicki, V.D. 1987. Single-void urine samples can be used to estimate quantitative microalbuminuria. Diabetes Care 10: 414-418.
12. Popov, D., Simionescu, M., and Shepherd, P.R. 2003. Saturated-fat diet induces moderate diabetes and severe glomerulosclerosis in hamsters. Diabetologia 46: 1408-1418.
13. Saito, T., Sumithran, E., Glasgow, E.F., and Atkins, R.C. 1987. The enhancement of aminonucleoside nephrosis by the co-administration of protamine. Kidney Int. 32: 691-699.
14. Samstein, B. and Platt, J. 2001. Physiologic and immunologic hurdles to xenotransplantation. J. Am. Soc. Nephrol. 12: 182-193.
15. Wallace, T.M., Levy, J.C., and Matthews, D.R. 2004. Use and abuse of HOMA modeling. Diabetes Care 27: 1487-1495.
16. Wang, P.R., Guo, Q., Ippolito, M., Wu, M., Milot, D., Ventre, J., Doebber, T., Wright, S.D., and Chao, Y.S. 2001. High fat fed hamster, a unique animal model for treatment of diabetic dyslipidemia with peroxisome proliferator activated receptor alpha selective agonists. Eur. J. Pharmacol. 427: 285-293.
17. Wei, P., Lane, P.H., Lane, J.T., Padanilam, B.J., and Sansom, S.C. 2004. Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes. Diabetologia 47: 1541-1549.
18. Wilson, S.H., Chade, A.R., Feldstein, A., Sawamura, T., Napoli, C., Lerman, A., and Lerman, L.O. 2003. Lipid-lowering-independent effects of simvastatin on the kidney in experimental hypercholesterolaemia. Nephrol. Dial. Transplant. 18: 703-709.
19. Winzell, M.S. and Ahren, B. 2004. The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes. Diabetes 53: S215-S219.
20. Xi, S., Yin, W., Wang, Z., Kusunoki, M., Lian, X, Koike, T., Fan, J., and Zhang, Q. 2004. A minipig model of high-fat/high-sucrose diet-induced diabetes and atherosclerosis. Int. J. Exp. Path. 85: 223-231.